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Index > Protein center > LMNB1(Gene name) > Human
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  • LMNB1 (Gene name),
  • Lamin-B1 (Protein name ),  LMNB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    LMNB1(LMN2;LMNB);
    Protein name:
    Lamin-B1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with lamin-associated polypeptides IA, IB and 2.
    Function:
    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
    Subcellular Location:
    Nucleus inner membrane Lipid-anchor Nucleoplasmic side
    Protein Attributes:
    Sequence length:
    586
    Sequence:
    50:
    MATATPVPPR | MGSRAGGPTT | PLSPTRLSRL | QEKEELRELN | DRLAVYIDKV | 
    100:
    RSLETENSAL | QLQVTEREEV | RGRELTGLKA | LYETELADAR | RALDDTARER | 
    150:
    AKLQIELGKC | KAEHDQLLLN | YAKKESDLNG | AQIKLREYEA | ALNSKDAALA | 
    200:
    TALGDKKSLE | GDLEDLKDQI | AQLEASLAAA | KKQLADETLL | KVDLENRCQS | 
    250:
    LTEDLEFRKS | MYEEEINETR | RKHETRLVEV | DSGRQIEYEY | KLAQALHEMR | 
    300:
    EQHDAQVRLY | KEELEQTYHA | KLENARLSSE | MNTSTVNSAR | EELMESRMRI | 
    350:
    ESLSSQLSNL | QKESRACLER | IQELEDLLAK | EKDNSRRMLT | DKEREMAEIR | 
    400:
    DQMQQQLNDY | EQLLDVKLAL | DMEISAYRKL | LEGEEERLKL | SPSPSSRVTV | 
    450:
    SRASSSRSVR | TTRGKRKRVD | VEESEASSSV | SISHSASATG | NVCIEEIDVD | 
    500:
    GKFIRLKNTS | EQDQPMGGWE | MIRKIGDTSV | SYKYTSRYVL | KAGQTVTIWA | 
    550:
    ANAGVTASPP | TDLIWKNQNS | WGTGEDVKVI | LKNSQGEEVA | QRSTVFKTTI | 
    586:
    PEEEEEEEEA | AGVVVEEELF | HQQGTPRASN | RSCAIM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Lamin-B1
    MSDS:
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    ELISA Kit for Human Lamin-B1
    Cat.:
    E11921r
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    Packing:
    96T
    ELISA Kit for Human Lamin-B1
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    E11921m
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    Packing:
    96T
    ELISA Kit for Human Lamin-B1
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    E11921h
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    MSDS:
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    CLIA Kit for Human Lamin-B1
    Cat.:
    U11921h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Lamin-B1
    Cat.:
    U11921m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lamin-B1
    Cat.:
    U11921r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Lamin-B1
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Lamin-B1
    Polyclonal Antibody for Human Lamin-B1
    Polyclonal Antibody for Human Lamin-B1
    Cat.:
    P11921Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Lamin-B1
    Monoclonal Antibody for Human Lamin-B1
    Monoclonal Antibody for Human Lamin-B1
    Monoclonal Antibody for Human Lamin-B1
    Monoclonal Antibody for Human Lamin-B1
    Protein for Human Lamin-B1
    Protein for Human Lamin-B1
    Protein for Human Lamin-B1
    Protein for Human Lamin-B1

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    Linearity
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    References
    1. 1.
      "In vitro posttranslational modification of lamin B cloned from a human T-cell line."
      Pollard K.M. , Chan E.K.L. , Grant B.J. , Sullivan K.F. , Tan E.M. , Glass C.A.
      Mol. Cell. Biol.10:2164-2175(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1."
      Lin F. , Worman H.J.
      Genomics27:230-236(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
      tissue: Placenta.
    6. 6.
      Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-10; 15-26; 43-49; 80-90; 103-109; 112-123; 125-191; 198-220; 235-250; 259-271; 277-290; 300-312; 321-330; 351-387; 475-483 AND 517-528;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    7. 7.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 52-67; 80-90; 112-123; 146-156; 198-208; 210-220; 300-312; 321-330; 351-378 AND 458-473;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    8. 8.
      "Human lamin B contains a farnesylated cysteine residue."
      Farnsworth C.C. , Wolda S.L. , Gelb M.H. , Glomset J.A.
      J. Biol. Chem.264:20422-20429(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISOPRENYLATION AT CYS-583
    9. 9.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20 AND SER-23;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Lamin B1 duplications cause autosomal dominant leukodystrophy."
      Padiath Q.S. , Saigoh K. , Schiffmann R. , Asahara H. , Yamada T. , Koeppen A. , Hogan K. , Ptacek L.J. , Fu Y.-H.
      Nat. Genet.38:1114-1123(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ADLD
    12. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-23 AND THR-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 16.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-157; LYS-271 AND LYS-483;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3; THR-5; SER-23; SER-375 AND THR-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-210 AND THR-575;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1."
      Ruan J. , Xu C. , Bian C. , Lam R. , Wang J.P. , Kania J. , Min J. , Zang J.
      FEBS Lett.586:314-318(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 311-388;X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 428-550;DISULFIDE BOND;SUBUNIT
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-436
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