LRP1 ELISA Kit for Human(Homo sapiens) | EIAab.comLRP1 ELISA Kit for Human(Homo sapiens)

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LRP1 (Gene name),

Prolow-density lipoprotein receptor-related protein 1 (Protein name ), LRP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

LRP1(A2MR;APR);

Protein name:

Prolow-density lipoprotein receptor-related protein 1(LRP-1);

Alternative:

Apolipoprotein E receptor(APOER);Alpha-2-macroglobulin receptor(A2MR);

CD:

CD91;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Interacts with bacterial exotoxins.

Function:

Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Subcellular Location:

Low-density lipoprotein receptor-related protein 1 intracellular domain Cytoplasm Nucleus After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.

Protein Attributes:

Sequence length:

4544

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NFTNPVYATL | YMGGHGSRHS | LASTDEKREL | LGRGPEDEIG | DPLA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.162757

SMR:

Q07954

Pfam:

PF07645

String:

Q07954

MIM:

107770

Pfam:

PF12662

KEGG:

hsa:4035

Uniprot:

Q07954

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ELISA Kit for Human LRP-1

Cat.:

E2072h

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Manual:

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Packing:

96T

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ELISA Kit for Human LRP-1

Cat.:

E2072m

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human LRP-1

Cat.:

E2072c

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MSDS:

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Packing:

96T

CLIA Kit for Human LRP-1

Cat.:

U2072c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human LRP-1

Cat.:

U2072m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human LRP-1

Cat.:

U2072h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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Polyclonal Antibody for Human LRP-1

Cat.:

P2072Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LRP-1

Cat.:

P2072Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human LRP-1

Monoclonal Antibody for Human LRP-1

Protein for Human LRP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Aβ1-40 clearance from the brain by regulation of LRP-1: A study on effects of insulin, rosiglitazone or the combination in type 2 diabetic GK rats"

M Zhu, W Xu, Z Zhao, G Ma, M Bao, Z Sun

From:Biomedicine & Aging Pathology

References

1.

"Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor."
Herz J. , Hamann U. , Rogne S. , Myklebost O. , Gausepohl H. , Stanley K.K.
EMBO J.7:4119-4127(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-2900
tissue: Liver.
2.

"Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein."
Van Leuven F. , Stas L. , Hilliker C. , Lorent K. , Umans L. , Serneels L. , Overbergh L. , Torrekens S. , Moechars D. , De Strooper B. , Van den Berghe H.
Genomics24:78-89(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms."
Van Leuven F. , Stas L. , Thiry E. , Nelissen B. , Miyake Y.
Genomics52:138-144(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-2900
4.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-2900
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Skin.
7.

"Structure of the low-density lipoprotein receptor-related protein (LRP) promoter."
Kutt H. , Herz J. , Stanley K.K.
Biochim. Biophys. Acta1009:229-236(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11
8.

Glaeser C.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11
tissue: Blood.
9.

"Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor."
Strickland D.K. , Ashcom J.D. , Williams S. , Burgess W.H. , Migliorini M. , Argraves W.S.
J. Biol. Chem.265:17401-17404(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 150-166; 234-252; 685-695; 902-916; 1096-1109; 1743-1756; 2863-2874; 2949-2960; 3023-3039 AND 3277-3291
tissue: Placenta.
10.

"Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment."
Herz J. , Kowal R.C. , Goldstein J.L. , Brown M.S.
EMBO J.9:1769-1776(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
11.

"Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor."
Kristensen T. , Moestrup S.K. , Gliemann J. , Bendtsen L. , Sand O. , Sottrup-Jensen L.
FEBS Lett.276:151-155(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A."
Kounnas M.Z. , Morris R.E. , Thompson M.R. , FitzGerald D.J. , Strickland D.K. , Saelinger C.B.
J. Biol. Chem.267:12420-12423(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR P.AERUGINOSA EXOA TOXIN
13.

"Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)."
Su H.P. , Nakada-Tsukui K. , Tosello-Trampont A.-C. , Li Y. , Bu G. , Henson P.M. , Ravichandran K.S.
J. Biol. Chem.277:11772-11779(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GULP1;MUTAGENESIS OF ASN-4470 AND ASN-4504
14.

"Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF."
Loukinova E. , Ranganathan S. , Kuznetsov S. , Gorlatova N. , Migliorini M.M. , Loukinov D. , Ulery P.G. , Mikhailenko I. , Lawrence D.A. , Strickland D.K.
J. Biol. Chem.277:15499-15506(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-4507;MUTAGENESIS OF 4470-ASN--TYR-4473 AND 4504-ASN--TYR-4507;INTERACTION WITH PDGF
15.

"Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain."
May P. , Reddy Y.K. , Herz J.
J. Biol. Chem.277:18736-18743(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC PROCESSING
16.

"The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65."
Kinoshita A. , Shah T. , Tangredi M.M. , Strickland D.K. , Hyman B.T.
J. Biol. Chem.278:41182-41188(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
17.

"LDL receptor-related proteins in neurodevelopment."
May P. , Herz J.
Traffic4:291-301(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules."
Ranganathan S. , Liu C.-X. , Migliorini M.M. , Von Arnim C.A.F. , Peltan I.D. , Mikhailenko I. , Hyman B.T. , Strickland D.K.
J. Biol. Chem.279:40536-40544(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-4460; SER-4517; SER-4520 AND SER-4523;MUTAGENESIS OF THR-4460; THR-4472; SER-4517; SER-4520 AND SER-4523;INTERACTION WITH SHC1; GULP1 AND DAB1
19.

"Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking."
Knauth P. , Schlueter T. , Czubayko M. , Kirsch C. , Florian V. , Schreckenberger S. , Hahn H. , Bohnensack R.
J. Mol. Biol.347:813-825(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX17
20.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-446; ASN-729; ASN-2127 AND ASN-3048
tissue: Plasma.
21.

"Identification of the ligands of protein interaction domains through a functional approach."
Caratu G. , Allegra D. , Bimonte M. , Schiattarella G.G. , D'Ambrosio C. , Scaloni A. , Napolitano M. , Russo T. , Zambrano N.
Mol. Cell. Proteomics6:333-345(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CUBN AND PID1;INTERACTION WITH CUBN AND PID1
22.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-446; ASN-729; ASN-1511; ASN-1575; ASN-1616; ASN-1645; ASN-1763; ASN-2127; ASN-2815; ASN-3048; ASN-3089; ASN-3488; ASN-3788; ASN-3953; ASN-4075 AND ASN-4125
tissue: Liver.
23.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-729 AND ASN-1511
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein."
Huang W. , Dolmer K. , Gettins P.G.W.
J. Biol. Chem.274:14130-14136(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1059-1100 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS
26.

"NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin."
Dolmer K. , Huang W. , Gettins P.G.W.
J. Biol. Chem.275:3264-3269(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 851-893 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS
27.

"Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor."
Simonovic M. , Dolmer K. , Huang W. , Strickland D.K. , Volz K. , Gettins P.G.
Biochemistry40:15127-15134(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1012-1054 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS
28.

"Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif."
Jensen G.A. , Andersen O.M.J.J. , Bonvin A.M. , Bjerrum-Bohr I. , Etzerodt M. , Thoegersen H.C. , O'Shea C. , Poulsen F.M. , Kragelund B.B.
J. Mol. Biol.362:700-716(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 932-1013 IN COMPLEX WITH LRPAP1 AND CALCIUM IONS;DISULFIDE BONDS
29.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-869 AND HIS-3760
30.

"Diagnostic exome sequencing in persons with severe intellectual disability."
de Ligt J. , Willemsen M.H. , van Bon B.W. , Kleefstra T. , Yntema H.G. , Kroes T. , Vulto-van Silfhout A.T. , Koolen D.A. , de Vries P. , Gilissen C. , del Rosario M. , Hoischen A. , Scheffer H. , de Vries B.B. , Brunner H.G. , Veltman J.A. , Vissers L.E.
N. Engl. J. Med.367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-3258

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