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Index > Protein center > LRP4(Gene name) > Human
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  • LRP4 (Gene name),
  • Low-density lipoprotein receptor-related protein 4 (Protein name ),  LRP4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LRP4(KIAA0816;LRP10;MEGF7);
    Protein name:
    Low-density lipoprotein receptor-related protein 4(LRP-4);
    Alternative:
    Multiple epidermal growth factor-like domains 7;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1905
    Sequence:
    50:
    MRRQWGALLL | GALLCAHGLA | SSPECACGRS | HFTCAVSALG | ECTCIPAQWQ | 
    100:
    CDGDNDCGDH | SDEDGCILPT | CSPLDFHCDN | GKCIRRSWVC | DGDNDCEDDS | 
    150:
    DEQDCPPREC | EEDEFPCQNG | YCIRSLWHCD | GDNDCGDNSD | EQCDMRKCSD | 
    200:
    KEFRCSDGSC | IAEHWYCDGD | TDCKDGSDEE | NCPSAVPAPP | CNLEEFQCAY | 
    250:
    GRCILDIYHC | DGDDDCGDWS | DESDCSSHQP | CRSGEFMCDS | GLCINAGWRC | 
    300:
    DGDADCDDQS | DERNCTTSMC | TAEQFRCHSG | RCVRLSWRCD | GEDDCADNSD | 
    350:
    EENCENTGSP | QCALDQFLCW | NGRCIGQRKL | CNGVNDCGDN | SDESPQQNCR | 
    400:
    PRTGEENCNV | NNGGCAQKCQ | MVRGAVQCTC | HTGYRLTEDG | HTCQDVNECA | 
    450:
    EEGYCSQGCT | NSEGAFQCWC | ETGYELRPDR | RSCKALGPEP | VLLFANRIDI | 
    500:
    RQVLPHRSEY | TLLLNNLENA | IALDFHHRRE | LVFWSDVTLD | RILRANLNGS | 
    550:
    NVEEVVSTGL | ESPGGLAVDW | VHDKLYWTDS | GTSRIEVANL | DGAHRKVLLW | 
    600:
    QNLEKPRAIA | LHPMEGTIYW | TDWGNTPRIE | ASSMDGSGRR | IIADTHLFWP | 
    650:
    NGLTIDYAGR | RMYWVDAKHH | VIERANLDGS | HRKAVISQGL | PHPFAITVFE | 
    700:
    DSLYWTDWHT | KSINSANKFT | GKNQEIIRNK | LHFPMDIHTL | HPQRQPAGKN | 
    750:
    RCGDNNGGCT | HLCLPSGQNY | TCACPTGFRK | ISSHACAQSL | DKFLLFARRM | 
    800:
    DIRRISFDTE | DLSDDVIPLA | DVRSAVALDW | DSRDDHVYWT | DVSTDTISRA | 
    850:
    KWDGTGQEVV | VDTSLESPAG | LAIDWVTNKL | YWTDAGTDRI | EVANTDGSMR | 
    900:
    TVLIWENLDR | PRDIVVEPMG | GYMYWTDWGA | SPKIERAGMD | ASGRQVIISS | 
    950:
    NLTWPNGLAI | DYGSQRLYWA | DAGMKTIEFA | GLDGSKRKVL | IGSQLPHPFG | 
    1000:
    LTLYGERIYW | TDWQTKSIQS | ADRLTGLDRE | TLQENLENLM | DIHVFHRRRP | 
    1050:
    PVSTPCAMEN | GGCSHLCLRS | PNPSGFSCTC | PTGINLLSDG | KTCSPGMNSF | 
    1100:
    LIFARRIDIR | MVSLDIPYFA | DVVVPINITM | KNTIAIGVDP | QEGKVYWSDS | 
    1150:
    TLHRISRANL | DGSQHEDIIT | TGLQTTDGLA | VDAIGRKVYW | TDTGTNRIEV | 
    1200:
    GNLDGSMRKV | LVWQNLDSPR | AIVLYHEMGF | MYWTDWGENA | KLERSGMDGS | 
    1250:
    DRAVLINNNL | GWPNGLTVDK | ASSQLLWADA | HTERIEAADL | NGANRHTLVS | 
    1300:
    PVQHPYGLTL | LDSYIYWTDW | QTRSIHRADK | GTGSNVILVR | SNLPGLMDMQ | 
    1350:
    AVDRAQPLGF | NKCGSRNGGC | SHLCLPRPSG | FSCACPTGIQ | LKGDGKTCDP | 
    1400:
    SPETYLLFSS | RGSIRRISLD | TSDHTDVHVP | VPELNNVISL | DYDSVDGKVY | 
    1450:
    YTDVFLDVIR | RADLNGSNME | TVIGRGLKTT | DGLAVDWVAR | NLYWTDTGRN | 
    1500:
    TIEASRLDGS | CRKVLINNSL | DEPRAIAVFP | RKGYLFWTDW | GHIAKIERAN | 
    1550:
    LDGSERKVLI | NTDLGWPNGL | TLDYDTRRIY | WVDAHLDRIE | SADLNGKLRQ | 
    1600:
    VLVSHVSHPF | ALTQQDRWIY | WTDWQTKSIQ | RVDKYSGRNK | ETVLANVEGL | 
    1650:
    MDIIVVSPQR | QTGTNACGVN | NGGCTHLCFA | RASDFVCACP | DEPDSRPCSL | 
    1700:
    VPGLVPPAPR | ATGMSEKSPV | LPNTPPTTLY | SSTTRTRTSL | EEVEGRCSER | 
    1750:
    DARLGLCARS | NDAVPAAPGE | GLHISYAIGG | LLSILLILVV | IAALMLYRHK | 
    1800:
    KSKFTDPGMG | NLTYSNPSYR | TSTQEVKIEA | IPKPAMYNQL | CYKKEGGPDH | 
    1850:
    NYTKEKIKIV | EGICLLSGDD | AEWDDLKQLR | SSRGGLLRDH | VCMKTDTVSI | 
    1900:
    QASSGSLDDT | ETEQLLQEEQ | SECSSVHTAA | TPERRGSLPD | TGWKHERKLS | 
    1905:
    SESQV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human LRP-4
    Cat.:
    E1102h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human LRP-4
    Cat.:
    E1102r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human LRP-4
    Cat.:
    E1102m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LRP-4
    Cat.:
    U1102r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LRP-4
    Cat.:
    U1102h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LRP-4
    Cat.:
    U1102m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LRP-4
    Cat.:
    P1102Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LRP-4
    Cat.:
    P1102Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LRP-4
    Cat.:
    P1102Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LRP-4
    Monoclonal Antibody for Human LRP-4
    Monoclonal Antibody for Human LRP-4
    Protein for Human LRP-4
    Protein for Human LRP-4
    Protein for Human LRP-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Low density lipoprotein receptor-related protein 10."
      Ishikawa K. , Fujimoto H. , Kim D. , Saeki S.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
      tissue: Brain.
    2. 2.
      "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening."
      Nakayama M. , Nakajima D. , Nagase T. , Nomura N. , Seki N. , Ohara O.
      Genomics51:27-34(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
      tissue: Brain.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-1086; GLY-1554 AND GLN-1646
      tissue: Muscle.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE REGULATION OF CANONICAL WTN SIGNALING;VARIANTS CLSS ASN-137; TYR-160; ASN-449; PRO-461; PHE-473; ASN-529 AND ARG-1017;CHARACTERIZATION OF VARIANTS CLSS ASN-137; TYR-160; ASN-449; PHE-473 AND ASN-529
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SOST;TISSUE SPECIFICITY;VARIANTS SOST2 TRP-1170 AND SER-1186;CHARACTERIZATION OF VARIANTS SOST2 TRP-1170 AND SER-1186;IDENTIFICATION BY MASS SPECTROMETRY
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