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Index > Protein center > LTC4S(Gene name) > Human
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  • LTC4S (Gene name),
  • Leukotriene C4 synthase (Protein name ),  LTC4S_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    LTC4S;
    Protein name:
    Leukotriene C4 synthase(LTC4 synthase);
    Alternative:
    Leukotriene-C(4) synthase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Interacts with ALOX5AP and ALOX5.
    Function:
    Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
    Subcellular Location:
    Nucleus outer membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    150
    Sequence:
    50:
    MKDEVALLAA | VTLLGVLLQA | YFSLQVISAR | RAFRVSPPLT | TGPPEFERVY | 
    100:
    RAQVNCSEYF | PLFLATLWVA | GIFFHEGAAA | LCGLVYLFAR | LRYFQGYARS | 
    150:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human LTC4 synthase
    Cat.:
    E10100h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human LTC4 synthase
    Cat.:
    E10100b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human LTC4 synthase
    Cat.:
    E10100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human LTC4 synthase
    Cat.:
    E10100r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human LTC4 synthase
    MSDS:
    Please sign in first.
    CLIA Kit for Human LTC4 synthase
    Cat.:
    U10100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LTC4 synthase
    Cat.:
    U10100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LTC4 synthase
    Cat.:
    U10100r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LTC4 synthase
    Polyclonal Antibody for Human LTC4 synthase
    Cat.:
    P10100Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LTC4 synthase
    Polyclonal Antibody for Human LTC4 synthase
    Monoclonal Antibody for Human LTC4 synthase
    Monoclonal Antibody for Human LTC4 synthase
    Monoclonal Antibody for Human LTC4 synthase
    Monoclonal Antibody for Human LTC4 synthase
    Protein for Human LTC4 synthase
    Protein for Human LTC4 synthase
    Protein for Human LTC4 synthase
    Protein for Human LTC4 synthase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4."
      Lam B.K. , Penrose J.F. , Freeman G.J. , Austen K.F.
      Proc. Natl. Acad. Sci. U.S.A.91:7663-7667(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-22 AND 35-48
      tissue: Bone marrow.
    2. 2.
      "Molecular cloning and expression of human leukotriene-C4 synthase."
      Welsch D.J. , Creely D.P. , Hauser S.D. , Mathis K.J. , Krivi G.G. , Isakson P.C.
      Proc. Natl. Acad. Sci. U.S.A.91:9745-9749(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35."
      Penrose J.F. , Spector J. , Baldasaro M. , Xu K. , Boyce J. , Arm J.P. , Austen K.F. , Lam B.K.
      J. Biol. Chem.271:11356-11361(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35."
      Bigby T.D. , Hodulik C.R. , Arden K.C. , Fu L.
      Mol. Med.2:637-646(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-142
      tissue: Brain.
    6. 6.
      "Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits."
      Nicholson D.W. , Ali A. , Vaillancourt J.P. , Calaycay J.R. , Mumford R.A. , Zamboni R.J. , Ford-Hutchinson A.W.
      Proc. Natl. Acad. Sci. U.S.A.90:2015-2019(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-35
    7. 7.
      "Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody."
      Penrose J.F. , Spector J. , Lam B.K. , Friend D.S. , Xu K. , Jack R.M. , Austen K.F.
      Am. J. Respir. Crit. Care Med.152:283-289(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-19;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Lung.
    8. 8.
      "Two step purification of human and murine leukotriene C4 synthase."
      Goppelt-Struebe M.
      Biochim. Biophys. Acta1256:257-261(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-17
      tissue: Monocyte.
    9. 9.
      "Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome."
      Mayatepek E. , Flock B.
      Lancet352:1514-1517(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LTC4 SYNTHASE DEFICIENCY
    10. 10.
      "Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism."
      Mayatepek E. , Zelezny R. , Lehmann W.D. , Hammond J.W. , Hoffmann G.F.
      J. Inherit. Metab. Dis.23:404-408(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LTC4 SYNTHASE DEFICIENCY
    11. 11.
      "Membrane localization and topology of leukotriene C4 synthase."
      Christmas P. , Weber B.M. , McKee M. , Brown D. , Soberman R.J.
      J. Biol. Chem.277:28902-28908(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY
    12. 12.
      "Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein."
      Strid T. , Svartz J. , Franck N. , Hallin E. , Ingelsson B. , Soederstroem M. , Hammarstroem S.
      Biochem. Biophys. Res. Commun.381:518-522(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALOX5AP AND ALOX5;SUBCELLULAR LOCATION
    13. 13.
      "Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis."
      Ago H. , Kanaoka Y. , Irikura D. , Lam B.K. , Shimamura T. , Austen K.F. , Miyano M.
      Nature448:609-612(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE;ACTIVE SITE;TOPOLOGY;SUBUNIT
    14. 14.
      "Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase."
      Martinez Molina D. , Wetterholm A. , Kohl A. , McCarthy A.A. , Niegowski D. , Ohlson E. , Hammarberg T. , Eshaghi S. , Haeggstroem J.Z. , Nordlund P.
      Nature448:613-616(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-150 IN COMPLEX WITH GLUTATHIONE;SUBUNIT;TOPOLOGY
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