SELE ELISA Kit for Human(Homo sapiens) | EIAab.comSELE ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SELE(Gene name) > Human

SELE (Gene name),

E-selectin (Protein name ), LYAM2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SELE(ELAM1);

Protein name:

E-selectin;

Alternative:

Endothelial leukocyte adhesion molecule 1(ELAM-1);CD62 antigen-like family member E;Leukocyte-endothelial cell adhesion molecule 2(LECAM2);

CD:

CD62E;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

Function:

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

610

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

610:

GSYQKPSYIL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00008

SMR:

P16581

STRING:

9606.ENSP00000331736

MIM:

131210

UniGene:

Hs.82848

String:

P16581

KEGG:

hsa:6401

Uniprot:

P16581

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ELISA Kit for Human E-selectin

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E0029h

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96T

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ELISA Kit for Human E-selectin

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E0029m

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96T

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ELISA Kit for Human E-selectin

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ELISA Kit for Human E-selectin

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E0029r

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ELISA Kit for Human E-selectin

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E0029p

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ELISA Kit for Human E-selectin

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E0029d

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ELISA Kit for Human E-selectin

Cat.:

E0029b

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96T

CLIA Kit for Human E-selectin

Cat.:

U0029p

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96T

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CLIA Kit for Human E-selectin

Cat.:

U0029h

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Looking for manual.

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96T

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CLIA Kit for Human E-selectin

Cat.:

U0029m

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human E-selectin

MSDS:

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CLIA Kit for Human E-selectin

Cat.:

U0029r

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Looking for manual.

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96T

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CLIA Kit for Human E-selectin

Cat.:

U0029d

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96T

CLIA Kit for Human E-selectin

Cat.:

U0029b

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96T

Polyclonal Antibody for Human E-selectin

Cat.:

P0029Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human E-selectin

Cat.:

P0029Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human E-selectin

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P0029Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human E-selectin

Protein for Human E-selectin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.1%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ELAM1 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	95-104
Plasma	98	93-99

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ELAM1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-95%	85-89%	95-100%	93-98%
EDTA plasma(n=5)	98-105%	99-104%	92-96%	91-98%
heparin plasma(n=5)	89-93%	91-96%	95-104%	98-107%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."
Hession C. , Osborn L. , Goff D. , Chi-Rosso G. , Vassallo C. , Pasek M. , Pittack C. , Tizard R. , Goelz S. , McCarthy K. , Hopple S. , Lobb R.
Proc. Natl. Acad. Sci. U.S.A.87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
tissue: Umbilical vein endothelial cell.
2.

"Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."
Bevilacqua M.P. , Stengelin S. , Gimbrone M.A. Jr. , Seed B.
Science243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."
Collins T. , Williams A. , Johnston G.I. , Kim J. , Eddy R. , Shows T. , Gimbrone M.A. Jr. , Bevilacqua M.P.
J. Biol. Chem.266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

SeattleSNPs variation discovery resource
Submitted (2002-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."
Phillips M.L. , Nudelman E. , Gaeta F.C. , Perez M. , Singhal A.K. , Hakomori S. , Paulson J.C.
Science250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND
9.

"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
Kerr S.C. , Fieger C.B. , Snapp K.R. , Rosen S.D.
J. Immunol.181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PODXL2
10.

"Modelling the carbohydrate recognition domain of human E-selectin."
Mills A.
FEBS Lett.319:5-11(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF LECTIN DOMAIN
11.

"Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."
Graves B.J. , Crowther R.L. , Chandran C. , Rumberger J.M. , Li S. , Huang K.-S. , Presky D.H. , Familletti P.C. , Wolitzky B.A. , Burns D.K.
Nature367:532-538(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 22-178
12.

"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell103:467-479(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 22-178 IN COMPLEX WITH CALCIUM IONS AND SELPLG;SUBUNIT;DISULFIDE BONDS
13.

Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell105:971-971(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
14.

"E-selectin polymorphism and atherosclerosis: an association study."
Wenzel K. , Felix S. , Kleber F.X. , Brachold R. , Menke T. , Schattke S. , Schulte K.L. , Glaser C. , Rohde K. , Baumann G. , Speer A.
Hum. Mol. Genet.3:1935-1937(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-149
15.

"DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
Wenzel K. , Ernst M. , Rohde K. , Baumann G. , Speer A.
Hum. Genet.97:15-20(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-149 AND PHE-575
16.

"A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."
Ye S.Q. , Usher D. , Virgil D. , Zhang L.Q. , Yochim S.E. , Gupta R.
J. Biomed. Sci.6:18-21(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-149
17.

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575
18.

"Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."
Sass C. , Pallaud C. , Zannad F. , Visvikis S.
Hum. Genet.107:58-61(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PHE-575

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