SELP ELISA Kit for Human(Homo sapiens) | EIAab.comSELP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SELP(Gene name) > Human

SELP (Gene name),

P-selectin (Protein name ), LYAM3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

SELP(GMRP;GRMP);

Protein name:

P-selectin;

Alternative:

Granule membrane protein 140(GMP-140);CD62 antigen-like family member P;Platelet activation dependent granule-external membrane protein(PADGEM);Leukocyte-endothelial cell adhesion molecule 3(LECAM3);

CD:

CD62P;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

Function:

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

830

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

830:

QKDDGKCPLN | PHSHLGTYGV | FTNAAFDPSP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.73800

String:

P16109

Pfam:

PF00059

MIM:

173610

KEGG:

hsa:6403

STRING:

9606.ENSP00000263686

SMR:

P16109

Uniprot:

P16109

FOR

ELISA Kit for Human P-selectin

Cat.:

E0115h

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Packing:

96T

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ELISA Kit for Human P-selectin

Cat.:

E0115m

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96T

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ELISA Kit for Human P-selectin

Cat.:

E0115r

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Packing:

96T

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ELISA Kit for Human P-selectin

Cat.:

E0115b

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Packing:

96T

CLIA Kit for Human P-selectin

Cat.:

U0115m

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human P-selectin

Cat.:

U0115h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human P-selectin

Cat.:

U0115r

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MSDS:

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Packing:

96T

CLIA Kit for Human P-selectin

Cat.:

U0115b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human P-selectin

Cat.:

P0115Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human P-selectin

Cat.:

P0115Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human P-selectin

Cat.:

P0115Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human P-selectin

Monoclonal Antibody for Human P-selectin

Protein for Human P-selectin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(3-hydroxyhexanoate-co-3-hydroxyoctanoate)"

Z Chen, S Cheng, K Xu.

From:http://www.sciencedirect.com/science/article/pii/S0142961208010727

References

1.

"Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation."
Johnston G.I. , Cook R.G. , McEver R.P.
Cell56:1033-1044(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANTS ILE-274 AND ASN-603
2.

SeattleSNPs variation discovery resource
Submitted (2002-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-179; MET-209; PHE-230; ILE-274; ASN-331; LEU-385; LYS-542; ASN-603; ALA-619; VAL-631; VAL-640; ASN-661; SER-673 AND PRO-756
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-640
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-640
5.

"P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage."
Fujimoto T. , Stroud E. , Whatley R.E. , Prescott S.M. , Muszbek L. , Laposata M. , McEver R.P.
J. Biol. Chem.268:11394-11400(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-807;STEAROYLATION AT CYS-807
6.

"A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding."
Sako D. , Comess K.M. , Barone K.M. , Camphausen R.T. , Cumming D.A. , Shaw G.D.
Cell83:323-331(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELPLG
7.

"PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus."
Pouyani T. , Seed B.
Cell83:333-343(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELPLG;FUNCTION
8.

"Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin."
Wilkins P.P. , Moore K.L. , McEver R.P. , Cummings R.D.
J. Biol. Chem.270:22677-22680(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SELPLG
9.

"A new member of the sorting nexin family interacts with the C-terminus of P-selectin."
Florian V. , Schlueter T. , Bohnensack R.
Biochem. Biophys. Res. Commun.281:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX17
10.

"Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking."
Knauth P. , Schlueter T. , Czubayko M. , Kirsch C. , Florian V. , Schreckenberger S. , Hahn H. , Bohnensack R.
J. Mol. Biol.347:813-825(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX17
11.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-54
tissue: Platelet.
12.

"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
Kerr S.C. , Fieger C.B. , Snapp K.R. , Rosen S.D.
J. Immunol.181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PODXL2
13.

"Structure and function of the epidermal growth factor domain of P-selectin."
Freedman S.J. , Sanford D.G. , Bachovchin W.W. , Furie B.C. , Baleja J.D. , Furie B.
Biochemistry35:13733-13744(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 160-199
14.

"Knowledge-based model building of proteins: concepts and examples."
Bajorath J. , Stenkamp R. , Aruffo A.
Protein Sci.2:1798-1810(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 42-161
15.

"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell103:467-479(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 42-198 IN COMPLEX WITH CALCIUM IONS AND SELPLG;SUBUNIT;DISULFIDE BONDS AT 60-CYS--CYS-158; 131-CYS--CYS-150; 163-CYS--CYS-183 AND 185-CYS--CYS-194
16.

Somers W.S. , Tang J. , Shaw G.D. , Camphausen R.T.
Cell105:971-971(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
17.

"The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction."
Herrmann S.M. , Ricard S. , Nicaud V. , Mallet C. , Evans A. , Ruidavets J.B. , Arveiler D. , Luc G. , Cambien F.
Hum. Mol. Genet.7:1277-1284(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-331; ASN-603; VAL-640 AND PRO-756
18.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-209; LEU-301; ASN-331; VAL-365; PHE-500; ASN-603; VAL-640 AND PRO-756
19.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
20.

"Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis."
Zee R.Y.L. , Cook N.R. , Cheng S. , Reynolds R. , Erlich H.A. , Lindpaintner K. , Ridker P.M.
Hum. Mol. Genet.13:389-396(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT VAL-640 WITH SUSCEPTIBILITY TO ISCHSTR

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