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Index > Protein center > MTDH(Gene name) > Human
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  • MTDH (Gene name),
  • Protein LYRIC (Protein name ),  LYRIC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MTDH(AEG1;LYRIC);
    Protein name:
    Protein LYRIC;
    Alternative:
    Astrocyte elevated gene-1 protein(AEG-1);3D3/LYRIC;Metadherin;Lysine-rich CEACAM1 co-isolated protein;Metastasis adhesion protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BCIPP, CREBBP/CBP and RELA/p65.
    Function:
    Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Cell junction tight junction Nucleus nucleolus Cytoplasm perinuclear region In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
    Protein Attributes:
    Sequence length:
    582
    Sequence:
    50:
    MAARSWQDEL | AQQAEEGSAR | LREMLSVGLG | FLRTELGLDL | GLEPKRYPGW | 
    100:
    VILVGTGALG | LLLLFLLGYG | WAAACAGARK | KRRSPPRKRE | EAAAVPAAAP | 
    150:
    DDLALLKNLR | SEEQKKKNRK | KLSEKPKPNG | RTVEVAEGEA | VRTPQSVTAK | 
    200:
    QPPEIDKKNE | KSKKNKKKSK | SDAKAVQNSS | RHDGKEVDEG | AWETKISHRE | 
    250:
    KRQQRKRDKV | LTDSGSLDST | IPGIENTITV | TTEQLTTASF | PVGSKKNKGD | 
    300:
    SHLNVQVSNF | KSGKGDSTLQ | VSSGLNENLT | VNGGGWNEKS | VKLSSQISAG | 
    350:
    EEKWNSVSPA | SAGKRKTEPS | AWSQDTGDAN | TNGKDWGRSW | SDRSIFSGIG | 
    400:
    STAEPVSQST | TSDYQWDVSR | NQPYIDDEWS | GLNGLSSADP | NSDWNAPAEE | 
    450:
    WGNWVDEERA | SLLKSQEPIP | DDQKVSDDDK | EKGEGALPTG | KSKKKKKKKK | 
    500:
    KQGEDNSTAQ | DTEELEKEIR | EDLPVNTSKT | RPKQEKAFSL | KTISTSDPAE | 
    550:
    VLVKNSQPIK | TLPPATSTEP | SVILSKSDSD | KSSSQVPPIL | QETDKSKSNT | 
    582:
    KQNSVPPSQT | KSETSWESPK | QIKKKKKARR | ET
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein LYRIC
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    E1442h
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    ELISA Kit for Human Protein LYRIC
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    E1442m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Protein LYRIC
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    E1442r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Protein LYRIC
    Cat.:
    U1442r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Protein LYRIC
    Cat.:
    U1442m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein LYRIC
    Cat.:
    U1442h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Protein LYRIC
    Cat.:
    P1442Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein LYRIC
    Cat.:
    P1442Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein LYRIC
    Cat.:
    P1442Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein LYRIC
    Monoclonal Antibody for Human Protein LYRIC
    Monoclonal Antibody for Human Protein LYRIC
    Protein for Human Protein LYRIC
    Protein for Human Protein LYRIC
    Protein for Human Protein LYRIC

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    Linearity
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    References
    1. 1.
      "3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus."
      Sutherland H.G.E. , Lam Y.W. , Briers S. , Lamond A.I. , Bickmore W.A.
      Exp. Cell Res.294:94-105(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
    2. 2.
      "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells."
      Britt D.E. , Yang D.-F. , Yang D.-Q. , Flanagan D.L. , Callanan H. , Lim Y.-P. , Lin S.-H. , Hixson D.C.
      Exp. Cell Res.300:134-148(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
      tissue: Colon carcinoma.
    3. 3.
      "Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1."
      Kang D.-C. , Su Z.-Z. , Sarkar D. , Emdad L. , Volsky D.J. , Fisher P.B.
      Gene353:8-15(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
      tissue: Fetal astrocyte.
    4. 4.
      "LYRIC protein induces cell migration dependent on its cytoplasmic localization."
      Liang Y. , Liu G.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-317
      tissue: Brain.
      tissue: Skin.
      tissue: Testis.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-582
      tissue: Hepatoma.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION IN MAMMARY TUMORS
    8. 8.
      "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis."
      Brown D.M. , Ruoslahti E.
      Cancer Cell5:365-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION IN TUMORS
    9. 9.
      "Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis."
      Emdad L. , Sarkar D. , Su Z.-Z. , Randolph A. , Boukerche H. , Valerie K. , Fisher P.B.
      Cancer Res.66:1509-1516(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RELA;INDUCTION
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298; SER-415 AND SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells."
      Ash S.C. , Yang D.Q. , Britt D.E.
      Biochem. Biophys. Res. Commun.371:333-338(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCCIP
    12. 12.
      "Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1."
      Sarkar D. , Park E.S. , Emdad L. , Lee S.-G. , Su Z.-Z. , Fisher P.B.
      Cancer Res.68:1478-1484(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CREBBP
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-308; SER-311; SER-426; THR-458 AND SER-568;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer."
      Hu G. , Chong R.A. , Yang Q. , Wei Y. , Blanco M.A. , Li F. , Reiss M. , Au J.L.-S. , Haffty B.G. , Kang Y.
      Cancer Cell15:9-20(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-369;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143; SER-298; SER-306; SER-308 AND SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298 AND SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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