Gene name:
MAP3K5(ASK1;MAPKKK5;MEKK5);
Protein name:
Mitogen-activated protein kinase kinase kinase 5;
Alternative:
MAPK/ERK kinase kinase 5(MEK kinase 5;MEKK 5);Apoptosis signal-regulating kinase 1(ASK-1);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L. Interacts with ARRB2. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.
Function:
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSTEADEGIT | FSVPPFAPSG | FCTIPEGGIC | RRGGAAAVGE | GEEHQLPPPP |
100:
PGSFWNVESA | AAPGIGCPAA | TSSSSATRGR | GSSVGGGSRR | TTVAYVINEA |
150:
SQGQLVVAES | EALQSLREAC | ETVGATLETL | HFGKLDFGET | TVLDRFYNAD |
200:
IAVVEMSDAF | RQPSLFYHLG | VRESFSMANN | IILYCDTNSD | SLQSLKEIIC |
250:
QKNTMCTGNY | TFVPYMITPH | NKVYCCDSSF | MKGLTELMQP | NFELLLGPIC |
300:
LPLVDRFIQL | LKVAQASSSQ | YFRESILNDI | RKARNLYTGK | ELAAELARIR |
350:
QRVDNIEVLT | ADIVINLLLS | YRDIQDYDSI | VKLVETLEKL | PTFDLASHHH |
400:
VKFHYAFALN | RRNLPGDRAK | ALDIMIPMVQ | SEGQVASDMY | CLVGRIYKDM |
450:
FLDSNFTDTE | SRDHGASWFK | KAFESEPTLQ | SGINYAVLLL | AAGHQFESSF |
500:
ELRKVGVKLS | SLLGKKGNLE | KLQSYWEVGF | FLGASVLAND | HMRVIQASEK |
550:
LFKLKTPAWY | LKSIVETILI | YKHFVKLTTE | QPVAKQELVD | FWMDFLVEAT |
600:
KTDVTVVRFP | VLILEPTKIY | QPSYLSINNE | VEEKTISIWH | VLPDDKKGIH |
650:
EWNFSASSVR | GVSISKFEER | CCFLYVLHNS | DDFQIYFCTE | LHCKKFFEMV |
700:
NTITEEKGRS | TEEGDCESDL | LEYDYEYDEN | GDRVVLGKGT | YGIVYAGRDL |
750:
SNQVRIAIKE | IPERDSRYSQ | PLHEEIALHK | HLKHKNIVQY | LGSFSENGFI |
800:
KIFMEQVPGG | SLSALLRSKW | GPLKDNEQTI | GFYTKQILEG | LKYLHDNQIV |
850:
HRDIKGDNVL | INTYSGVLKI | SDFGTSKRLA | GINPCTETFT | GTLQYMAPEI |
900:
IDKGPRGYGK | AADIWSLGCT | IIEMATGKPP | FYELGEPQAA | MFKVGMFKVH |
950:
PEIPESMSAE | AKAFILKCFE | PDPDKRACAN | DLLVDEFLKV | SSKKKKTQPK |
1000:
LSALSAGSNE | YLRSISLPVP | VLVEDTSSSS | EYGSVSPDTE | LKVDPFSFKT |
1050:
RAKSCGERDV | KGIRTLFLGI | PDENFEDHSA | PPSPEEKDSG | FFMLRKDSER |
1100:
RATLHRILTE | DQDKIVRNLM | ESLAQGAEEP | KLKWEHITTL | IASLREFVRS |
1150:
TDRKIIATTL | SKLKLELDFD | SHGISQVQVV | LFGFQDAVNK | VLRNHNIKPH |
1200:
WMFALDSIIR | KAVQTAITIL | VPELRPHFSL | ASESDTADQE | DLDVEDDHEE |
1250:
QPSNQTVRRP | QAVIEDAVAT | SGVSTLSSTV | SHDSQSAHRS | LNVQLGRMKI |
1300:
ETNRLLEELV | RKEKELQALL | HRAIEEKDQE | IKHLKLKSQP | IEIPELPVFH |
1350:
LNSSGTNTED | SELTDWLRVN | GADEDTISRF | LAEDYTLLDV | LYYVTRDDLK |
1374:
CLRLRGGMLC | TLWKAIIDFR | NKQT
Vaild Sequence:
Related Databases
Uniprot: