Gene name:
MAP3K8 (COT;ESTF) ;
Protein name:
Mitogen-activated protein kinase kinase kinase 8 ;
Alternative:
Proto-oncogene c-Cot ;Cancer Osaka thyroid oncogene ;Tumor progression locus 2 (TPL-2) ;Serine/threonine-protein kinase cot ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms a ternary complex with NFKB1 and TNIP2.
Function:
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MEYMSTGSDN | KEEIDLLIKH | LNVSDVIDIM | ENLYASEEPA | VYEPSLMTMC |
100:
QDSNQNDERS | KSLLLSGQEV | PWLSSVRYGT | VEDLLAFANH | ISNTAKHFYG |
150:
QRPQESGILL | NMVITPQNGR | YQIDSDVLLI | PWKLTYRNIG | SDFIPRGAFG |
200:
KVYLAQDIKT | KKRMACKLIP | VDQFKPSDVE | IQACFRHENI | AELYGAVLWG |
250:
ETVHLFMEAG | EGGSVLEKLE | SCGPMREFEI | IWVTKHVLKG | LDFLHSKKVI |
300:
HHDIKPSNIV | FMSTKAVLVD | FGLSVQMTED | VYFPKDLRGT | EIYMSPEVIL |
350:
CRGHSTKADI | YSLGATLIHM | QTGTPPWVKR | YPRSAYPSYL | YIIHKQAPPL |
400:
EDIADDCSPG | MRELIEASLE | RNPNHRPRAA | DLLKHEALNP | PREDQPRCQS |
450:
LDSALLERKR | LLSRKELELP | ENIADSSCTG | STEESEMLKR | QRSLYIDLGA |
467:
LAGYFNLVRG | PPTLEYG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
Protein for Human Mitogen-activated protein kinase kinase kinase 8
Protein for Human Mitogen-activated protein kinase kinase kinase 8
Protein for Human Mitogen-activated protein kinase kinase kinase 8
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Tongue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112
tissue :
T-cell .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE INITIATION;FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NFKB1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH KSR2
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NFKB1
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-290;INTERACTION WITH KSR2;MUTAGENESIS OF THR-290
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NFKB1 AND TNIP2
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-290
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-80; SER-400 AND SER-443
20.
"Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."
Watford W.T.
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Hissong B.D.
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J. Exp. Med.205:2803-2812(2008)
[
PubMed ]
[
Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT SER-62; THR-290 AND SER-400;MUTAGENESIS OF SER-62; LYS-167; ASP-270; THR-290 AND SER-400
23.
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Tanti J.F.
Diabetes59:61-70(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-400