MAPRE1 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPRE1 ELISA Kit for Human(Homo sapiens)

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MAPRE1 (Gene name),

Microtubule-associated protein RP/EB family member 1 (Protein name ), MARE1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPRE1;

Protein name:

Microtubule-associated protein RP/EB family member 1;

Alternative:

End-binding protein 1(EB1);APC-binding protein EB1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with DCTN1, DCTN2, DIAPH1, DIAPH2, TERF1 and dynein intermediate chain. Interacts with APC (via C-terminal domain), CLASP2, DST, KIF2C and STIM1; probably required for their targeting to the growing microtubule plus ends. Interacts with MTUS2; interaction is direct and probably targets MTUS2 to microtubules. Interacts with APC2. Interacts with CLASP1. Interacts with CDK5RAP2. Interacts with MACF1.

Function:

May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.

Subcellular Location:

Cytoplasm cytoskeleton Cytoplasm cytoskeleton centrosome Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.

Protein Attributes:

Sequence length:

268

Sequence:

50:

100:

150:

200:

250:

268:

EGFVIPDEGG | PQEEQEEY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.472437

Pfam:

PF00307

SMR:

Q15691

MIM:

603108

String:

Q15691

KEGG:

hsa:22919

STRING:

9606.ENSP00000364721

Uniprot:

Q15691

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ELISA Kit for Human Microtubule-associated protein RP/EB family member 1

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E2190m

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ELISA Kit for Human Microtubule-associated protein RP/EB family member 1

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E2190r

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ELISA Kit for Human Microtubule-associated protein RP/EB family member 1

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E2190c

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ELISA Kit for Human Microtubule-associated protein RP/EB family member 1

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E2190h

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ELISA Kit for Human Microtubule-associated protein RP/EB family member 1

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E2190b

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96T

CLIA Kit for Human Microtubule-associated protein RP/EB family member 1

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U2190m

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CLIA Kit for Human Microtubule-associated protein RP/EB family member 1

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U2190r

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CLIA Kit for Human Microtubule-associated protein RP/EB family member 1

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U2190c

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CLIA Kit for Human Microtubule-associated protein RP/EB family member 1

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U2190b

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CLIA Kit for Human Microtubule-associated protein RP/EB family member 1

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U2190h

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Polyclonal Antibody for Human Microtubule-associated protein RP/EB family member 1

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P2190Rb-r

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Polyclonal Antibody for Human Microtubule-associated protein RP/EB family member 1

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P2190Rb-m

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Polyclonal Antibody for Human Microtubule-associated protein RP/EB family member 1

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P2190Rb-h

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Monoclonal Antibody for Human Microtubule-associated protein RP/EB family member 1

Protein for Human Microtubule-associated protein RP/EB family member 1

R&D Technical Data

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Precision

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Recovery

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References

1.

"APC binds to the novel protein EB1."
Su L.-K. , Burrell M. , Hill D.E. , Gyuris J. , Brent R. , Wiltshire R. , Trent J. , Vogelstein B. , Kinzler K.W.
Cancer Res.55:2972-2977(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH APC
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
3.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

Bienvenut W.V. , Potts A. , Barblan J. , Quadroni M.
Submitted (2004-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-17;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: B-cell lymphoma.
7.

"The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules."
Berrueta L. , Kraeft S.-K. , Tirnauer J.S. , Schuyler S.C. , Chen L.B. , Hill D.E. , Pellman D. , Bierer B.E.
Proc. Natl. Acad. Sci. U.S.A.95:10596-10601(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain."
Berrueta L. , Tirnauer J.S. , Schuyler S.C. , Pellman D. , Bierer B.E.
Curr. Biol.9:425-428(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCTN1; DCTN2 AND DYNEIN INTERMEDIATE CHAIN
9.

"EB/RP gene family encodes tubulin binding proteins."
Juwana J.-P. , Henderikx P. , Mischo A. , Wadle A. , Fadle N. , Gerlach K. , Arends J.W. , Hoogenboom H. , Pfreundschuh M. , Renner C.
Int. J. Cancer81:275-284(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TUBULIN
10.

"EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue."
Nakagawa H. , Koyama K. , Murata Y. , Morito M. , Akiyama T. , Nakamura Y.
Oncogene19:210-216(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APC2;TISSUE SPECIFICITY
11.

"Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle."
Nakamura M. , Zhen Zhou X. , Kishi S. , Ping Lu K.
FEBS Lett.514:193-198(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TERF1
12.

"Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome."
Askham J.M. , Vaughan K.T. , Goodson H.V. , Morrison E.E.
Mol. Biol. Cell13:3627-3645(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APC AND DCTN1;SUBCELLULAR LOCATION;FUNCTION
13.

"Characterization of functional domains of human EB1 family proteins."
Bu W. , Su L.-K.
J. Biol. Chem.278:49721-49731(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;INTERACTION WITH TUBULIN; APC AND DCTN1
14.

"CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex."
Mimori-Kiyosue Y. , Grigoriev I. , Lansbergen G. , Sasaki H. , Matsui C. , Severin F. , Galjart N. , Grosveld F. , Vorobjev I. , Tsukita S. , Akhmanova A.
J. Cell Biol.168:141-153(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLASP1 AND CLASP2
15.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-124;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition."
Mishima M. , Maesaki R. , Kasa M. , Watanabe T. , Fukata M. , Kaibuchi K. , Hakoshima T.
Proc. Natl. Acad. Sci. U.S.A.104:10346-10351(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLIP1
17.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"TIP150 interacts with and targets MCAK at the microtubule plus ends."
Jiang K. , Wang J. , Liu J. , Ward T. , Wordeman L. , Davidson A. , Wang F. , Yao X.
EMBO Rep.10:857-865(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MTUS2 AND KIF2C
19.

"Mammalian end binding proteins control persistent microtubule growth."
Komarova Y. , De Groot C.O. , Grigoriev I. , Gouveia S.M. , Munteanu E.L. , Schober J.M. , Honnappa S. , Buey R.M. , Hoogenraad C.C. , Dogterom M. , Borisy G.G. , Steinmetz M.O. , Akhmanova A.
J. Cell Biol.184:691-706(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPRE3
20.

"Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics."
Fong K.W. , Hau S.Y. , Kho Y.S. , Jia Y. , He L. , Qi R.Z.
Mol. Biol. Cell20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK5RAP2
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases."
Tanenbaum M.E. , Macurek L. , van der Vaart B. , Galli M. , Akhmanova A. , Medema R.H.
Curr. Biol.21:1356-1365(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIF18B
23.

"SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase."
van der Vaart B. , Manatschal C. , Grigoriev I. , Olieric V. , Gouveia S.M. , Bjelic S. , Demmers J. , Vorobjev I. , Hoogenraad C.C. , Steinmetz M.O. , Akhmanova A.
J. Cell Biol.193:1083-1099(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLAIN2 AND CLIP1;FUNCTION;SUBCELLULAR LOCATION
24.

"Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules."
Wang X. , Zhuang X. , Cao D. , Chu Y. , Yao P. , Liu W. , Liu L. , Adams G. , Fang G. , Dou Z. , Ding X. , Huang Y. , Wang D. , Yao X.
J. Biol. Chem.287:39380-39390(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KNSTRN
25.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression."
Zhu M. , Settele F. , Kotak S. , Sanchez-Pulido L. , Ehret L. , Ponting C.P. , Goenczy P. , Hoffmann I.
J. Cell Biol.200:773-787(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MISP
28.

"Structural insights into the EB1-APC interaction."
Honnappa S. , John C.M. , Kostrewa D. , Winkler F.K. , Steinmetz M.O.
EMBO J.24:261-269(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) OF 191-268;DIMERIZATION;INTERACTION WITH APC
29.

"Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)."
Hayashi I. , Ikura M.
J. Biol. Chem.278:36430-36434(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 1-130;MUTAGENESIS OF 59-LYS-LYS-60 AND LYS-89
30.

"Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex."
Hayashi I. , Wilde A. , Mal T.K. , Ikura M.
Mol. Cell19:449-460(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 183-268 IN COMPLEX WITH DCTN1;FUNCTION;SUBUNIT;INTERACTION WITH DCTN1;SUBCELLULAR LOCATION
31.

"Key interaction modes of dynamic +TIP networks."
Honnappa S. , Okhrimenko O. , Jaussi R. , Jawhari H. , Jelesarov I. , Winkler F.K. , Steinmetz M.O.
Mol. Cell23:663-671(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 191-267 IN COMPLEX WITH DCTN1
32.

"Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1."
Slep K.C. , Vale R.D.
Mol. Cell27:976-991(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 12-133
33.

"An EB1-binding motif acts as a microtubule tip localization signal."
Honnappa S. , Gouveia S.M. , Weisbrich A. , Damberger F.F. , Bhavesh N.S. , Jawhari H. , Grigoriev I. , van Rijssel F.J. , Buey R.M. , Lawera A. , Jelesarov I. , Winkler F.K. , Wuthrich K. , Akhmanova A. , Steinmetz M.O.
Cell138:366-376(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 191-260 IN COMPLEX WITH DST;FUNCTION;INTERACTION WITH APC; CLASP2; KIF2C AND STIM1;SUBCELLULAR LOCATION

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