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Index > Protein center > MASP2(Gene name) > Human
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  • MASP2 (Gene name),
  • Mannan-binding lectin serine protease 2 (Protein name ),  MASP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MASP2;
    Protein name:
    Mannan-binding lectin serine protease 2;
    Alternative:
    Mannose-binding protein-associated serine protease 2(MASP-2);MBL-associated serine protease 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.
    Function:
    Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    686
    Sequence:
    50:
    MRLLTLLGLL | CGSVATPLGP | KWPEPVFGRL | ASPGFPGEYA | NDQERRWTLT | 
    100:
    APPGYRLRLY | FTHFDLELSH | LCEYDFVKLS | SGAKVLATLC | GQESTDTERA | 
    150:
    PGKDTFYSLG | SSLDITFRSD | YSNEKPFTGF | EAFYAAEDID | ECQVAPGEAP | 
    200:
    TCDHHCHNHL | GGFYCSCRAG | YVLHRNKRTC | SALCSGQVFT | QRSGELSSPE | 
    250:
    YPRPYPKLSS | CTYSISLEEG | FSVILDFVES | FDVETHPETL | CPYDFLKIQT | 
    300:
    DREEHGPFCG | KTLPHRIETK | SNTVTITFVT | DESGDHTGWK | IHYTSTAQPC | 
    350:
    PYPMAPPNGH | VSPVQAKYIL | KDSFSIFCET | GYELLQGHLP | LKSFTAVCQK | 
    400:
    DGSWDRPMPA | CSIVDCGPPD | DLPSGRVEYI | TGPGVTTYKA | VIQYSCEETF | 
    450:
    YTMKVNDGKY | VCEADGFWTS | SKGEKSLPVC | EPVCGLSART | TGGRIYGGQK | 
    500:
    AKPGDFPWQV | LILGGTTAAG | ALLYDNWVLT | AAHAVYEQKH | DASALDIRMG | 
    550:
    TLKRLSPHYT | QAWSEAVFIH | EGYTHDAGFD | NDIALIKLNN | KVVINSNITP | 
    600:
    ICLPRKEAES | FMRTDDIGTA | SGWGLTQRGF | LARNLMYVDI | PIVDHQKCTA | 
    650:
    AYEKPPYPRG | SVTANMLCAG | LESGGKDSCR | GDSGGALVFL | DSETERWFVG | 
    686:
    GIVSWGSMNC | GEAGQYGVYT | KVINYIPWIE | NIISDF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mannan-binding lectin serine protease 2
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    E2234h
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    ELISA Kit for Human Mannan-binding lectin serine protease 2
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    ELISA Kit for Human Mannan-binding lectin serine protease 2
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    CLIA Kit for Human Mannan-binding lectin serine protease 2
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    U2234h
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    Range:
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    CLIA Kit for Human Mannan-binding lectin serine protease 2
    Cat.:
    U2234m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Mannan-binding lectin serine protease 2
    Cat.:
    U2234r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Mannan-binding lectin serine protease 2
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    40ug/0.2ml
    Polyclonal Antibody for Human Mannan-binding lectin serine protease 2
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    P2234Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Mannan-binding lectin serine protease 2
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    P2234Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Mannan-binding lectin serine protease 2
    Monoclonal Antibody for Human Mannan-binding lectin serine protease 2
    Monoclonal Antibody for Human Mannan-binding lectin serine protease 2
    Protein for Human Mannan-binding lectin serine protease 2
    Protein for Human Mannan-binding lectin serine protease 2
    Protein for Human Mannan-binding lectin serine protease 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A second serine protease associated with mannan-binding lectin that activates complement."
      Thiel S. , Vorup-Jensen T. , Stover C.M. , Schwaeble W.J. , Laursen S.B. , Poulsen K. , Willis A.C. , Eggleton P. , Hansen S. , Holmskov U. , Reid K.B.M. , Jensenius J.C.
      Nature386:506-510(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway."
      Takahashi M. , Endo Y. , Fujita T. , Matsushita M.
      Int. Immunol.11:859-863(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
    3. 3.
      "Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene."
      Stover C.M. , Thiel S. , Thelen M. , Lynch N.J. , Vorup-Jensen T. , Jensenius J.C. , Schwaeble W.J.
      J. Immunol.162:3481-3490(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);ACTIVATION BY PROTEOLYTIC CLEAVAGE;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Liver.
    4. 4.
      "Identification and characterization of a novel protein of the human complement system, mannan-binding lectin-associated serine protease-2 (MASP-2)."
      Thiel S. , Vorup-Jensen T. , Stover C.M. , Schwaeble W. , Laursen S.B. , Poulsen K. , Willis A.C. , Eggleton P. , Hansen S. , Holmskov U. , Reid K.B.M. , Jensenius J.C.
      Submitted (1998-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Partial genomic structure of human MBL-associated serine protease (MASP)-2 (from exon 1 to exon 5)."
      Takahashi M. , Fujita T.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TYR-371
    6. 6.
      "Structure of human MASP-2 gene."
      Park D. , Kim B. , Baek K. , Yoon J.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "Towards a comprehensive database of proteins from the urine of patients with bladder cancer."
      Rasmussen H.H. , Orntoft T.F. , Wolf H. , Celis J.E.
      J. Urol.155:2113-2119(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-45
      tissue: Urine.
    10. 10.
      "The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3."
      Stover C. , Endo Y. , Takahashi M. , Lynch N. , Constantinescu C. , Vorup-Jensen T. , Thiel S. , Friedl H. , Hankeln T. , Hall R. , Gregory S. , Fujita T. , Schwaeble W.
      Genes Immun.2:119-127(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 149-284 AND 364-686;VARIANT ALA-377
    11. 11.
      "Proteolytic activities of two types of mannose-binding lectin-associated serine protease."
      Matsushita M. , Thiel S. , Jensenius J.C. , Terai I. , Fujita T.
      J. Immunol.165:2637-2642(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SERPING1
    12. 12.
      "The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin."
      Gregory L.A. , Thielens N.M. , Matsushita M. , Sorensen R. , Arlaud G.J. , Fontecilla-Camps J.-C. , Gaboriaud C.
      J. Biol. Chem.279:29391-29397(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 16-181 (ISOFORM 2);CHARACTERIZATION OF VARIANT GLY-120;CALCIUM-BINDING SITES;DIMERIZATION;MUTAGENESIS OF TYR-74; TYR-121 AND GLU-124;INTERACTION WITH MBL2 AND FCN2;DISULFIDE BONDS
    13. 13.
      "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions."
      Harmat V. , Gal P. , Kardos J. , Szilagyi K. , Ambrus G. , Vegh B. , Naray-Szabo G. , Zavodszky P.
      J. Mol. Biol.342:1533-1546(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 363-686;DISULFIDE BONDS
    14. 14.
      "A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations."
      Gal P. , Harmat V. , Kocsis A. , Bian T. , Barna L. , Ambrus G. , Vegh B. , Balczer J. , Sim R.B. , Naray-Szabo G. , Zavodszky P.
      J. Biol. Chem.280:33435-33444(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF 287-686;AUTOCATALYTIC CLEAVAGE AT ARG-444;MUTAGENESIS OF ARG-444
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MASPD GLY-120;CHARACTERIZATION OF VARIANT MASPD GLY-120
    16. 16.
      "Novel MASP2 variants detected among North African and Sub-Saharan individuals."
      Lozano F. , Suarez B. , Munoz A. , Jensenius J.C. , Mensa J. , Vives J. , Horcajada J.P.
      Tissue Antigens66:131-135(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-99; CYS-118; GLY-120 AND LEU-126
    17. 17.
      "Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms."
      Thiel S. , Steffensen R. , Christensen I.J. , Ip W.K. , Lau Y.L. , Reason I.J. , Eiberg H. , Gadjeva M. , Ruseva M. , Jensenius J.C.
      Genes Immun.8:154-163(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MASPD GLY-120; LEU-126 AND HIS-ASN-HIS-156 INS;VARIANTS GLN-99; CYS-118 AND ALA-377
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