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Index > Protein center > LPCAT3(Gene name) > Human
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  • LPCAT3 (Gene name),
  • Lysophospholipid acyltransferase 5 (Protein name ),  MBOA5_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    LPCAT3(MBOAT5;OACT5);
    Protein name:
    Lysophospholipid acyltransferase 5(LPLAT 5);
    Alternative:
    2.3.1.n6;1-acylglycerophosphoserine O-acyltransferase);2.3.1.23;1-acylglycerophosphocholine O-acyltransferase);Lysophosphatidylcholine acyltransferase 3(Lyso-PC acyltransferase 3);Lysophosphatidylcholine acyltransferase(LPCAT;Lyso-PC acyltransferase);Membrane-bound O-acyltransferase domain-containing protein 5(O-acyltransferase domain-containing protein 5);Lysophosphatidylserine acyltransferase(LPSAT;Lyso-PS acyltransferase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    487
    Sequence:
    50:
    MASSAEGDEG | TVVALAGVLQ | SGFQELSLNK | LATSLGASEQ | ALRLIISIFL | 
    100:
    GYPFALFYRH | YLFYKETYLI | HLFHTFTGLS | IAYFNFGNQL | YHSLLCIVLQ | 
    150:
    FLILRLMGRT | ITAVLTTFCF | QMAYLLAGYY | YTATGNYDIK | WTMPHCVLTL | 
    200:
    KLIGLAVDYF | DGGKDQNSLS | SEQQKYAIRG | VPSLLEVAGF | SYFYGAFLVG | 
    250:
    PQFSMNHYMK | LVQGELIDIP | GKIPNSIIPA | LKRLSLGLFY | LVGYTLLSPH | 
    300:
    ITEDYLLTED | YDNHPFWFRC | MYMLIWGKFV | LYKYVTCWLV | TEGVCILTGL | 
    350:
    GFNGFEEKGK | AKWDACANMK | VWLFETNPRF | TGTIASFNIN | TNAWVARYIF | 
    400:
    KRLKFLGNKE | LSQGLSLLFL | ALWHGLHSGY | LVCFQMEFLI | VIVERQAARL | 
    450:
    IQESPTLSKL | AAITVLQPFY | YLVQQTIHWL | FMGYSMTAFC | LFTWDKWLKV | 
    487:
    YKSIYFLGHI | FFLSLLFILP | YIHKAMVPRK | EKLKKME
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human LPLAT 5
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    E2212r
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    ELISA Kit for Human LPLAT 5
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    ELISA Kit for Human LPLAT 5
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    E2212b
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    ELISA Kit for Human LPLAT 5
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    E2212m
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    Packing:
    96T
    CLIA Kit for Human LPLAT 5
    Cat.:
    U2212b
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    Packing:
    96T
    CLIA Kit for Human LPLAT 5
    Cat.:
    U2212h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human LPLAT 5
    Cat.:
    U2212m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LPLAT 5
    Cat.:
    U2212r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human LPLAT 5
    Polyclonal Antibody for Human LPLAT 5
    Cat.:
    P2212Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LPLAT 5
    Cat.:
    P2212Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LPLAT 5
    Cat.:
    P2212Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LPLAT 5
    Monoclonal Antibody for Human LPLAT 5
    Monoclonal Antibody for Human LPLAT 5
    Monoclonal Antibody for Human LPLAT 5
    Protein for Human LPLAT 5
    Protein for Human LPLAT 5
    Protein for Human LPLAT 5
    Protein for Human LPLAT 5

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Endometrium.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Pancreas.
    5. 5.
      "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."
      Ansari-Lari M.A. , Shen Y. , Muzny D.M. , Lee W. , Gibbs R.A.
      Genome Res.7:268-280(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 50-487 (ISOFORM 1)
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-487 (ISOFORM 1/2)
    7. 7.
      "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase."
      Zhao Y. , Chen Y.Q. , Bonacci T.M. , Bredt D.S. , Li S. , Bensch W.R. , Moller D.E. , Kowala M. , Konrad R.J. , Cao G.
      J. Biol. Chem.283:8258-8265(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;FUNCTION;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
    8. 8.
      "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils."
      Gijon M.A. , Riekhof W.R. , Zarini S. , Murphy R.C. , Voelker D.R.
      J. Biol. Chem.283:30235-30245(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBSTRATE SPECIFICITY
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