Nr3c2 ELISA Kit for Mouse(Mus musculus) | EIAab.comNr3c2 ELISA Kit for Mouse(Mus musculus)

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Nr3c2 (Gene name),

Mineralocorticoid receptor (Protein name ), MCR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nr3c2(Mlr);

Protein name:

Mineralocorticoid receptor(MR);

Alternative:

Nuclear receptor subfamily 3 group C member 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. Binds the coactivator NCOA2. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, TIF1 and NRIP1.

Function:

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.

Subcellular Location:

Cytoplasm Nucleus Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.

Protein Attributes:

Sequence length:

978

Sequence:

50:

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650:

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950:

978:

PAMLVEIISD | QLPKVESGNA | KPLYFHRK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00104

SMR:

Q8VII8

UniGene:

Mm.324393

String:

Q8VII8

Uniprot:

Q8VII8

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ELISA Kit for Mouse MR

Cat.:

E0158r

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse MR

Cat.:

E0158m

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse MR

Cat.:

E0158h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse MR

Cat.:

E0158c

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse MR

Cat.:

E0158p

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MR

Cat.:

U0158c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MR

Cat.:

U0158p

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MR

Cat.:

U0158m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MR

Cat.:

U0158h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MR

Cat.:

U0158r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Mouse MR

Cat.:

P0158Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MR

Cat.:

P0158Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MR

Cat.:

P0158Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse MR

Protein for Mouse MR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes."
Beggah A.T. , Escoubet B. , Puttini S. , Cailmail S. , Delage V. , Ouvrard-Pascaud A. , Bocchi B. , Peuchmaur M. , Delcayre C. , Farman N. , Jaisser F.
Proc. Natl. Acad. Sci. U.S.A.99:7160-7165(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-109 AND 182-288
strain: C57BL/6 X DBA/2.
tissue: Heart.
3.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
4.

"Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."
Shibata S. , Nagase M. , Yoshida S. , Kawarazaki W. , Kurihara H. , Tanaka H. , Miyoshi J. , Takai Y. , Fujita T.
Nat. Med.14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION

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