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Index > Protein center > ABCB4(Gene name) > Human
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  • ABCB4 (Gene name),
  • Multidrug resistance protein 3 (Protein name ),  MDR3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ABCB4(MDR3;PGY3);
    Protein name:
    Multidrug resistance protein 3;
    Alternative:
    P-glycoprotein 3;ATP-binding cassette sub-family B member 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HAX1.
    Function:
    Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human MDR3 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1286
    Sequence:
    50:
    MDLEAAKNGT | AWRPTSAEGD | FELGISSKQK | RKKTKTVKMI | GVLTLFRYSD | 
    100:
    WQDKLFMSLG | TIMAIAHGSG | LPLMMIVFGE | MTDKFVDTAG | NFSFPVNFSL | 
    150:
    SLLNPGKILE | EEMTRYAYYY | SGLGAGVLVA | AYIQVSFWTL | AAGRQIRKIR | 
    200:
    QKFFHAILRQ | EIGWFDINDT | TELNTRLTDD | ISKISEGIGD | KVGMFFQAVA | 
    250:
    TFFAGFIVGF | IRGWKLTLVI | MAISPILGLS | AAVWAKILSA | FSDKELAAYA | 
    300:
    KAGAVAEEAL | GAIRTVIAFG | GQNKELERYQ | KHLENAKEIG | IKKAISANIS | 
    350:
    MGIAFLLIYA | SYALAFWYGS | TLVISKEYTI | GNAMTVFFSI | LIGAFSVGQA | 
    400:
    APCIDAFANA | RGAAYVIFDI | IDNNPKIDSF | SERGHKPDSI | KGNLEFNDVH | 
    450:
    FSYPSRANVK | ILKGLNLKVQ | SGQTVALVGS | SGCGKSTTVQ | LIQRLYDPDE | 
    500:
    GTINIDGQDI | RNFNVNYLRE | IIGVVSQEPV | LFSTTIAENI | CYGRGNVTMD | 
    550:
    EIKKAVKEAN | AYEFIMKLPQ | KFDTLVGERG | AQLSGGQKQR | IAIARALVRN | 
    600:
    PKILLLDEAT | SALDTESEAE | VQAALDKARE | GRTTIVIAHR | LSTVRNADVI | 
    650:
    AGFEDGVIVE | QGSHSELMKK | EGVYFKLVNM | QTSGSQIQSE | EFELNDEKAA | 
    700:
    TRMAPNGWKS | RLFRHSTQKN | LKNSQMCQKS | LDVETDGLEA | NVPPVSFLKV | 
    750:
    LKLNKTEWPY | FVVGTVCAIA | NGGLQPAFSV | IFSEIIAIFG | PGDDAVKQQK | 
    800:
    CNIFSLIFLF | LGIISFFTFF | LQGFTFGKAG | EILTRRLRSM | AFKAMLRQDM | 
    850:
    SWFDDHKNST | GALSTRLATD | AAQVQGATGT | RLALIAQNIA | NLGTGIIISF | 
    900:
    IYGWQLTLLL | LAVVPIIAVS | GIVEMKLLAG | NAKRDKKELE | AAGKIATEAI | 
    950:
    ENIRTVVSLT | QERKFESMYV | EKLYGPYRNS | VQKAHIYGIT | FSISQAFMYF | 
    1000:
    SYAGCFRFGA | YLIVNGHMRF | RDVILVFSAI | VFGAVALGHA | SSFAPDYAKA | 
    1050:
    KLSAAHLFML | FERQPLIDSY | SEEGLKPDKF | EGNITFNEVV | FNYPTRANVP | 
    1100:
    VLQGLSLEVK | KGQTLALVGS | SGCGKSTVVQ | LLERFYDPLA | GTVFVDFGFQ | 
    1150:
    LLDGQEAKKL | NVQWLRAQLG | IVSQEPILFD | CSIAENIAYG | DNSRVVSQDE | 
    1200:
    IVSAAKAANI | HPFIETLPHK | YETRVGDKGT | QLSGGQKQRI | AIARALIRQP | 
    1250:
    QILLLDEATS | ALDTESEKVV | QEALDKAREG | RTCIVIAHRL | STIQNADLIV | 
    1286:
    VFQNGRVKEH | GTHQQLLAQK | GIYFSMVSVQ | AGTQNL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multidrug resistance protein 3
    Cat.:
    E10409h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Multidrug resistance protein 3
    Cat.:
    E10409m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Multidrug resistance protein 3
    Cat.:
    E10409r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Multidrug resistance protein 3
    Cat.:
    U10409m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Multidrug resistance protein 3
    Cat.:
    U10409h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Multidrug resistance protein 3
    Cat.:
    U10409r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Multidrug resistance protein 3
    Cat.:
    P10409Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Multidrug resistance protein 3
    Polyclonal Antibody for Human Multidrug resistance protein 3
    Monoclonal Antibody for Human Multidrug resistance protein 3
    Monoclonal Antibody for Human Multidrug resistance protein 3
    Monoclonal Antibody for Human Multidrug resistance protein 3
    Protein for Human Multidrug resistance protein 3
    Protein for Human Multidrug resistance protein 3
    Protein for Human Multidrug resistance protein 3

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery

    Recovery was determined by spiking various levels of ABCB4 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    100

    97-108

    Plasma

    99

    95-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ABCB4 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    94-105%

    95-103%

    96-105%

    92-109%

    EDTA plasma(n=5)

    93-105%

    92-107%

    95-103%

    93-106%

    heparin plasma(n=5)

    94-104%

     

    91-105%

    92-108%

    91-109%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Sequence of mdr3 cDNA encoding a human P-glycoprotein."
      van der Bliek A.M. , Kooiman P.M. , Schneider C. , Borst P.
      Gene71:401-411(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      NIEHS SNPs program
      Submitted (2006-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-238; VAL-263; ASP-528; GLN-590; ASN-651; GLY-652 AND GLN-788
    3. 3.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "Characterization of the promoter region of the human MDR3 P-glycoprotein gene."
      Smit J.J. , Mol C.A. , van Deemter L. , Wagenaar E. , Schinkel A.H. , Borst P.
      Biochim. Biophys. Acta1261:44-56(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-72 (ISOFORM 1)
      tissue: Liver.
    6. 7.
      "The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver."
      van der Bliek A.M. , Baas F. , ten Houte de Lange T. , Kooiman P.M. , van der Velde-Koerts T. , Borst P.
      EMBO J.6:3325-3331(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 856-1286 (ISOFORM 1);ALTERNATIVE SPLICING
    7. 8.
      "Structure of the human MDR3 gene and physical mapping of the human MDR locus."
      Lincke C.R. , Smit J.J.M. , van der Velde-Koerts T. , Borst P.
      J. Biol. Chem.266:5303-5310(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PFIC3
    9. 10.
      "Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking."
      Dixon P.H. , Weerasekera N. , Linton K.J. , Donaldson O. , Chambers J. , Egginton E. , Weaver J. , Nelson-Piercy C. , de Swiet M. , Warnes G. , Elias E. , Higgins C.F. , Johnston D.G. , McCarthy M.I. , Williamson C.
      Hum. Mol. Genet.9:1209-1217(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ICP3 ASP-546;CHARACTERIZATION OF VARIANT ICP3 ASP-546
    10. 11.
      "The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood."
      Jacquemin E. , De Vree J.M.L. , Cresteil D. , Sokal E.M. , Sturm E. , Dumont M. , Scheffer G.L. , Paul M. , Burdelski M. , Bosma P.J. , Bernard O. , Hadchouel M. , Elferink R.P.
      Gastroenterology120:1448-1458(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PFIC3 ARG-138; ILE-346; GLY-395; ALA-424; MET-425; PHE-541; ARG-556; GLY-564; SER-711 AND SER-983;VARIANT GLY-652
    11. 12.
      "MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis."
      Rosmorduc O. , Hermelin B. , Poupon R.
      Gastroenterology120:1459-1467(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GBD1 PHE-320 AND SER-1168;VARIANT ALA-175
    12. 13.
      "A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis."
      Lucena J.-F. , Herrero J.I. , Quiroga J. , Sangro B. , Garcia-Foncillas J. , Zabalegui N. , Sola J. , Herraiz M. , Medina J.F. , Prieto J.
      Gastroenterology124:1037-1042(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PFIC3 ASP-535
    13. 14.
      "ABCB4 gene mutation-associated cholelithiasis in adults."
      Rosmorduc O. , Hermelin B. , Boelle P.Y. , Parc R. , Taboury J. , Poupon R.
      Gastroenterology125:452-459(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GBD1 ILE-165; THR-301; PHE-320; GLN-591; THR-934 AND SER-1168;VARIANTS ALA-175; ASP-528; GLN-590; GLY-652; SER-742 AND GLN-788
    14. 15.
      "ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy."
      Muellenbach R. , Linton K.J. , Wiltshire S. , Weerasekera N. , Chambers J. , Elias E. , Higgins C.F. , Johnston D.G. , McCarthy M.I. , Williamson C.
      J. Med. Genet.40:E70-E70(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ICP3 LYS-150;VARIANT GLY-652
    15. 16.
      "Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."
      Pauli-Magnus C. , Lang T. , Meier Y. , Zodan-Marin T. , Jung D. , Breymann C. , Zimmermann R. , Kenngott S. , Beuers U. , Reichel C. , Kerb R. , Penger A. , Meier P.J. , Kullak-Ublick G.A.
      Pharmacogenetics14:91-102(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-175; ASP-528; GLY-652 AND MET-775;VARIANTS ICP3 PHE-320 AND GLU-762
    16. 17.
      "Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."
      Lang T. , Haberl M. , Jung D. , Drescher A. , Schlagenhaufer R. , Keil A. , Mornhinweg E. , Stieger B. , Kullak-Ublick G.A. , Kerb R.
      Drug Metab. Dispos.34:1582-1599(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-87; SER-95; ALA-175; VAL-367; GLY-450; GLN-590 AND GLY-652
    17. 18.
      "Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury."
      Lang C. , Meier Y. , Stieger B. , Beuers U. , Lang T. , Kerb R. , Kullak-Ublick G.A. , Meier P.J. , Pauli-Magnus C.
      Pharmacogenet. Genomics17:47-60(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-175; GLN-590; GLY-652; LEU-764 AND GLN-1082
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