Mediator of RNA polymerase II transcription subunit 16 (Protein name
), MED16_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
MED16(DRIP92;THRAP5);
Protein name:
Mediator of RNA polymerase II transcription subunit 16;
Alternative:
Thyroid hormone receptor-associated protein 5;Mediator complex subunit 16;Vitamin D3 receptor-interacting protein complex 92 kDa component(DRIP92);Thyroid hormone receptor-associated protein complex 95 kDa component(Trap95);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 277-283;IDENTIFICATION IN TRAP COMPLEX;FUNCTION OF TRAP COMPLEX
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);PROTEIN SEQUENCE OF 27-42 AND 755-772;IDENTIFICATION IN ARC COMPLEX;FUNCTION OF ARC COMPLEX
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 248-877 (ISOFORM 4)
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
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Cited for: INTERACTION WITH MED1; MED10; MED21 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
Vaild Sequence:
