Gene name:
MED17 (ARC77;CRSP6;DRIP77;DRIP80;TRAP80) ;
Protein name:
Mediator of RNA polymerase II transcription subunit 17 ;
Alternative:
Cofactor required for Sp1 transcriptional activation subunit 6 (CRSP complex subunit 6) ;Activator-recruited cofactor 77 kDa component (ARC77) ;Thyroid hormone receptor-associated protein complex 80 kDa component (Trap80) ;Mediator complex subunit 17 ;Vitamin D3 receptor-interacting protein complex 80 kDa component (DRIP80) ;Transcriptional coactivator CRSP77 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSGVRAVRIS | IESACEKQVH | EVGLDGTETY | LPPLSMSQNL | ARLAQRIDFS |
100:
QGSGSEEEEA | AGTEGDAQEW | PGAGSSADQD | DEEGVVKFQP | SLWPWDSVRN |
150:
NLRSALTEMC | VLYDVLSIVR | DKKFMTLDPV | SQDALPPKQN | PQTLQLISKK |
200:
KSLAGAAQIL | LKGAERLTKS | VTENQENKLQ | RDFNSELLRL | RQHWKLRKVG |
250:
DKILGDLSYR | SAGSLFPHHG | TFEVIKNTDL | DLDKKIPEDY | CPLDVQIPSD |
300:
LEGSAYIKVS | IQKQAPDIGD | LGTVNLFKRP | LPKSKPGSPH | WQTKLEAAQN |
350:
VLLCKEIFAQ | LSREAVQIKS | QVPHIVVKNQ | IISQPFPSLQ | LSISLCHSSN |
400:
DKKSQKFATE | KQCPEDHLYV | LEHNLHLLIR | EFHKQTLSSI | MMPHPASAPF |
450:
GHKRMRLSGP | QAFDKNEINS | LQSSEGLLEK | IIKQAKHIFL | RSRAAATIDS |
500:
LASRIEDPQI | QAHWSNINDV | YESSVKVLIT | SQGYEQICKS | IQLQLNIGVE |
550:
QIRVVHRDGR | VITLSYQEQE | LQDFLLSQMS | QHQVHAVQQL | AKVMGWQVLS |
600:
FSNHVGLGPI | ESIGNASAIT | VASPSGDYAI | SVRNGPESGS | KIMVQFPRNQ |
650:
CKDLPKSDVL | QDNKWSHLRG | PFKEVQWNKM | EGRNFVYKME | LLMSALSPCL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Bovine
Human
Mouse
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17
ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17
CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17
Protein for Human Mediator of RNA polymerase II transcription subunit 17
Protein for Human Mediator of RNA polymerase II transcription subunit 17
Protein for Human Mediator of RNA polymerase II transcription subunit 17
Protein for Human Mediator of RNA polymerase II transcription subunit 17
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASP-69
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Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : INTERACTION WITH MED1; MED10; MED18; MED21; MED28 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ASP-69;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT MCPHSBA PRO-371