Protein name:
Lactadherin;
Alternative:
SED1;O-acetyl GD3 ganglioside synthase(AGS);MFGM;Milk fat globule-EGF factor 8(MFG-E8);
Organism:
Rat (Rattus norvegicus).
General annotation
Function:
Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid.
Subcellular Location:
Membrane
Peripheral membrane protein
Secreted
Protein attributes
50:
MQFSRVLAAL | CGVLLCASGL | FAASGDFCDS | SLCLNGGTCL | MGQDNDIYCL |
100:
CPEGFTGLVC | NETEKGPCSP | NPCFHDAKCL | VTEDTQRGDI | FTEYICQCPV |
150:
GYSGIHCELG | CSTKLGLEGG | AIADSQISAS | SVYMGFMGLQ | RWGPELARLY |
200:
RTGIVNAWTA | SSYDSKPWIQ | VDFLRKMRVS | GVMTQGASRA | GRAEYLKTFK |
250:
VAYSLDGRRF | EFIQDESGTG | DKEFMGNQDN | NSLKINMFNP | TLEAQYIRLY |
300:
PVSCHRGCTL | RFELLGCELH | GCSEPLGLKN | NTIPDSQITA | SSSYKTWNLR |
350:
AFGWYPHLGR | LDNQGKINAW | TAQSNSAKEW | LQVDLGTQKK | VTGIITQGAR |
400:
DFGHIQYVAS | YKVAHSDDGV | QWTVYEEQGT | SKVFQGNLDN | NSHKKNIFEK |
427:
PFMARYVRVL | PLSWHNRITL | RLELLGC

Vaild
Sequence:
Database Reference
Uniprot: