Gene name:
MICA(PERB11.1);
Protein name:
MHC class I polypeptide-related sequence A(MIC-A);
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells.
Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Cytoplasm
Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
Protein Attributes:
50:
MGLGPVFLLL | AGIFPFAPPG | AAAEPHSLRY | NLTVLSWDGS | VQSGFLTEVH |
100:
LDGQPFLRCD | RQKCRAKPQG | QWAEDVLGNK | TWDRETRDLT | GNGKDLRMTL |
150:
AHIKDQKEGL | HSLQEIRVCE | IHEDNSTRSS | QHFYYDGELF | LSQNLETKEW |
200:
TMPQSSRAQT | LAMNVRNFLK | EDAMKTKTHY | HAMHADCLQE | LRRYLKSGVV |
250:
LRRTVPPMVN | VTRSEASEGN | ITVTCRASGF | YPWNITLSWR | QDGVSLSHDT |
300:
QQWGDVLPDG | NGTYQTWVAT | RICQGEEQRF | TCYMEHSGNH | STHPVPSGKV |
350:
LVLQSHWQTF | HVSAVAAAAI | FVIIIFYVRC | CKKKTSAAEG | PELVSLQVLD |
383:
QHPVGTSDHR | DATQLGFQPL | MSDLGSTGST | EGA
Vaild Sequence:
Related Databases
Uniprot:
