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Index > Protein center > MIF(Gene name) > Human
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  • MIF (Gene name),
  • Macrophage migration inhibitory factor (Protein name ),  MIF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    MIF(GLIF;MMIF);
    Protein name:
    Macrophage migration inhibitory factor(MIF);
    Alternative:
    Phenylpyruvate tautomerase;5.3.3.12;L-dopachrome tautomerase);Glycosylation-inhibiting factor(GIF);L-dopachrome isomerase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
    Function:
    Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
    Subcellular Location:
    Secreted Cytoplasm Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
    Protein Attributes:
    Sequence length:
    115
    Sequence:
    50:
    MPMFIVNTNV | PRASVPDGFL | SELTQQLAQA | TGKPPQYIAV | HVVPDQLMAF | 
    100:
    GGSSEPCALC | SLHSIGKIGG | AQNRSYSKLL | CGLLAERLRI | SPDRVYINYY | 
    115:
    DMNAANVGWN | NSTFA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    String:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human MIF
    Cat.:
    E0698p
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human MIF
    Cat.:
    E0698b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human MIF
    Cat.:
    E0698r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human MIF
    Cat.:
    E0698h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human MIF
    Cat.:
    E0698m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human MIF
    Cat.:
    E0698c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIF
    Cat.:
    U0698m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MIF
    Cat.:
    U0698h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MIF
    Cat.:
    U0698b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIF
    Cat.:
    U0698p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIF
    Cat.:
    U0698c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MIF
    Cat.:
    U0698r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MIF
    Polyclonal Antibody for Human MIF
    Polyclonal Antibody for Human MIF
    Polyclonal Antibody for Human MIF
    Cat.:
    P0698Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MIF
    Cat.:
    P0698Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MIF
    Cat.:
    P0698Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MIF
    Monoclonal Antibody for Human MIF
    Monoclonal Antibody for Human MIF
    Monoclonal Antibody for Human MIF
    Monoclonal Antibody for Human MIF
    Monoclonal Antibody for Human MIF
    Protein for Human MIF
    Protein for Human MIF
    Protein for Human MIF
    Cat.:
    R0698m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human MIF
    Cat.:
    R0698h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human MIF
    Protein for Human MIF

    R&D Technical Data
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    12% SDS-PAGE analysis

           12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor."
      Weiser W.Y. , Temple P.A. , Witek-Giannotti J.S. , Remold H.G. , Clark S.C. , David J.R.
      Proc. Natl. Acad. Sci. U.S.A.86:7522-7526(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;SUBCELLULAR LOCATION
    2. 2.
      "Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor."
      Mikayama T. , Nakano T. , Gomi H. , Nakagawa Y. , Liu Y.C. , Iwamatsu A. , Weiser W.Y. , Ishizaka K. , Sato M. , Ishii Y.
      Proc. Natl. Acad. Sci. U.S.A.90:10056-10060(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
    3. 3.
      "Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF)."
      Bernhagen J. , Mitchell R.A. , Calandra T. , Voelter W. , Cerami A. , Bucala R.
      Biochemistry33:14144-14155(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Cloning the human gene for macrophage migration inhibitory factor (MIF)."
      Paralkar V. , Wistow G.J.
      Genomics19:48-51(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The effect of macrophage migration inhibitory factor in the atherogenesis process."
      Shan Z.X. , Yu X.Y. , Lin S.G. , Lin Q.X. , Fu Y.H. , Tan H.H.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Amplification and expression of macrophage migration inhibitory factor (MIF) in tissue of squamous carcinoma of the cervix."
      Wu S.H. , Xie J. , Shang H.X. , Li Y. , Zhang Z.
      Submitted (2007-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    9. 9.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 10.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    11. 11.
      NIEHS SNPs program
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
      tissue: Skin.
      tissue: Uterus.
    14. 14.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12
      tissue: Platelet.
    15. 15.
      "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
      Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11
      tissue: Liver.
    16. 16.
      "The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor."
      Zeng F.Y. , Weiser W.Y. , Kratzin H. , Stahl B. , Karas M. , Gabius H.J.
      Arch. Biochem. Biophys.303:74-80(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 3-24
    17. 17.
      "A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens."
      Wistow G.J. , Shaughnessy M. , Lee D.C. , Hodin J. , Zelenka P.S.
      Proc. Natl. Acad. Sci. U.S.A.90:1272-1275(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-115
      tissue: Lens.
    18. 18.
      "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1."
      Kleemann R. , Hausser A. , Geiger G. , Mischke R. , Burger-Kentischer A. , Flieger O. , Johannes F.-J. , Roger T. , Calandra T. , Kapurniotu A. , Grell M. , Finkelmeier D. , Brunner H. , Bernhagen J.
      Nature408:211-216(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5;SUBCELLULAR LOCATION
    19. 19.
      "A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis."
      The British peadiatric rheumatology study group , Donn R.P. , Shelley E. , Ollier W.E.R. , Thomson W.
      Arthritis Rheum.44:1782-1785(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO SYSTEMIC JUVENILE RHEUMATOID ARTHRITIS
    20. 20.
      "Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis."
      Tan T.H.P. , Edgerton S.A.V. , Kumari R. , McAlister M.S.B. , Roe S.M. , Nagl S. , Pearl L.H. , Selkirk M.E. , Bianco A.E. , Totty N.F. , Engwerda C. , Gray C.A. , Meyer D.J. , Rowe S.M.
      Biochem. J.357:373-383(2001) [PubMed] [Europe PMC] [Abstract]
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      Oddo M. , Calandra T. , Bucala R. , Meylan P.R.A.
      Infect. Immun.73:3783-3786(2005) [PubMed] [Europe PMC] [Abstract]
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      Emonts M. , Sweep F.C.G.J. , Grebenchtchikov N. , Geurts-Moespot A. , Knaup M. , Chanson A.L. , Erard V. , Renner P. , Hermans P.W.M. , Hazelzet J.A. , Calandra T.
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      Merk M. , Baugh J. , Zierow S. , Leng L. , Pal U. , Lee S.J. , Ebert A.D. , Mizue Y. , Trent J.O. , Mitchell R. , Nickel W. , Kavathas P.B. , Bernhagen J. , Bucala R.
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      Kato Y. , Muto T. , Tomura T. , Tsumura H. , Watarai H. , Mikayama T. , Ishizaka K. , Kuroki R.
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      Crichlow G.V. , Cheng K.F. , Dabideen D. , Ochani M. , Aljabari B. , Pavlov V.A. , Miller E.J. , Lolis E. , Al-Abed Y.
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      Fan C. , Rajasekaran D. , Syed M.A. , Leng L. , Loria J.P. , Bhandari V. , Bucala R. , Lolis E.J.
      Proc. Natl. Acad. Sci. U.S.A.110:10994-10999(2013) [PubMed] [Europe PMC] [Abstract]
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