Mitogen-activated protein kinase 3 (Protein name
), MK03_HUMAN from NCBI database.
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General Annotation
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Gene name:
MAPK3(ERK1;PRKM3);
Protein name:
Mitogen-activated protein kinase 3(MAP kinase 3;MAPK 3);
Alternative:
Extracellular signal-regulated kinase 1(ERK-1);ERT2;MAP kinase isoform p44(p44-MAPK);Insulin-stimulated MAP2 kinase;Mitogen-activated protein kinase 1(MAP kinase 1;MAPK 1);Microtubule-associated protein 2 kinase;p44-ERK1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MORG1. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By similarity). Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH. Interacts with ARRB2. Interacts with ADAM15.
Function:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.
"Properties of human ERK1b." Aebersold D.M.
,
Yung Y.
,
Seger R.
Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
3.
"Identification of dominant negative Erk1/2 variants in cancer cells." Cheng H.
,
Ren S.
,
Qiu R.
,
Wang M.
,
Feng Y.H.
Submitted (2006-02) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: PROTEIN SEQUENCE OF 2-15; 33-41; 88-94; 117-131; 212-220; 279-287; 303-318 AND 360-370;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-379 (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-379 (ISOFORM 1)
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Cited for: FUNCTION IN PHOSPHORYLATION OF CANX;INTERACTION WITH CANX
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Cited for: SUBCELLULAR LOCATION;INTERACTION WITH MAP2K1/MEK1;DOMAIN
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Cited for: FUNCTION IN PHOSPHORYLATION OF IER3;INTERACTION WITH IER3;ENZYME REGULATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-202 AND TYR-204;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN KIT SIGNALING PATHWAY;PHOSPHORYLATION
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Cited for: PHOSPHORYLATION AT TYR-204;DEPHOSPHORYLATION AT TYR-204 BY PTPRJ
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-198;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION AT THR-207;ENZYME REGULATION;SUBUNIT;SUBCELLULAR LOCATION
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Cited for: REVIEW ON FUNCTION;REVIEW ON SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-202 AND TYR-204;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-202 AND TYR-204;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS);PHOSPHORYLATION AT TYR-204