Gene name:
MAPK8 (JNK1;PRKM8;SAPK1;SAPK1C) ;
Protein name:
Mitogen-activated protein kinase 8 (MAP kinase 8;MAPK 8) ;
Alternative:
Stress-activated protein kinase 1 (SAPK1c) ;JNK-46 ;c-Jun N-terminal kinase 1 ;Stress-activated protein kinase JNK1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and RGNEF (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling.
Function:
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Subcellular Location:
N/A
Protein Attributes:
50:
MSRSKRDNNF | YSVEIGDSTF | TVLKRYQNLK | PIGSGAQGIV | CAAYDAILER |
100:
NVAIKKLSRP | FQNQTHAKRA | YRELVLMKCV | NHKNIIGLLN | VFTPQKSLEE |
150:
FQDVYIVMEL | MDANLCQVIQ | MELDHERMSY | LLYQMLCGIK | HLHSAGIIHR |
200:
DLKPSNIVVK | SDCTLKILDF | GLARTAGTSF | MMTPYVVTRY | YRAPEVILGM |
250:
GYKENVDLWS | VGCIMGEMVC | HKILFPGRDY | IDQWNKVIEQ | LGTPCPEFMK |
300:
KLQPTVRTYV | ENRPKYAGYS | FEKLFPDVLF | PADSEHNKLK | ASQARDLLSK |
350:
MLVIDASKRI | SVDEALQHPY | INVWYDPSEA | EAPPPKIPDK | QLDEREHTIE |
400:
EWKELIYKEV | MDLEERTKNG | VIRGQPSPLG | AAVINGSQHP | SSSSSVNDVS |
427:
SMSTDPTLAS | DTDSSLEAAA | GPLGCCR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human MAP kinase 8
ELISA Kit for Human MAP kinase 8
ELISA Kit for Human MAP kinase 8
CLIA Kit for Human MAP kinase 8
CLIA Kit for Human MAP kinase 8
CLIA Kit for Human MAP kinase 8
Polyclonal Antibody for Human MAP kinase 8
Polyclonal Antibody for Human MAP kinase 8
Polyclonal Antibody for Human MAP kinase 8
Monoclonal Antibody for Human MAP kinase 8
Monoclonal Antibody for Human MAP kinase 8
Monoclonal Antibody for Human MAP kinase 8
Protein for Human MAP kinase 8
Protein for Human MAP kinase 8
Protein for Human MAP kinase 8
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Fetal brain .
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-183 AND TYR-185;REGULATION BY MAP2K4 AND MAP2K7;COFACTOR
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF JDP2
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF BCL2
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 (ISOFORMS 1 AND 3);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Mol. Biol. Cell22:117-127(2011)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CDT1
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EMBO J.23:2185-2195(2004)
[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] SER-171 AND ARG-177