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Index > Protein center > MAPK14(Gene name) > Human
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  • MAPK14 (Gene name),
  • Mitogen-activated protein kinase 14 (Protein name ),  MK14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAPK14(CSBP;CSBP1;CSBP2;CSPB1;MXI2;SAPK2A);
    Protein name:
    Mitogen-activated protein kinase 14(MAP kinase 14;MAPK 14);
    Alternative:
    MAP kinase MXI2;Cytokine suppressive anti-inflammatory drug-binding protein(CSAID-binding protein;CSBP);Mitogen-activated protein kinase p38 alpha(MAP kinase p38 alpha);MAX-interacting protein 2;SAPK2A(SAPK2a);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity). Interacts with NP60 and FAM48A.
    Function:
    Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MSQERPTFYR | QELNKTIWEV | PERYQNLSPV | GSGAYGSVCA | AFDTKTGLRV | 
    100:
    AVKKLSRPFQ | SIIHAKRTYR | ELRLLKHMKH | ENVIGLLDVF | TPARSLEEFN | 
    150:
    DVYLVTHLMG | ADLNNIVKCQ | KLTDDHVQFL | IYQILRGLKY | IHSADIIHRD | 
    200:
    LKPSNLAVNE | DCELKILDFG | LARHTDDEMT | GYVATRWYRA | PEIMLNWMHY | 
    250:
    NQTVDIWSVG | CIMAELLTGR | TLFPGTDHID | QLKLILRLVG | TPGAELLKKI | 
    300:
    SSESARNYIQ | SLTQMPKMNF | ANVFIGANPL | AVDLLEKMLV | LDSDKRITAA | 
    350:
    QALAHAYFAQ | YHDPDDEPVA | DPYDQSFESR | DLLIDEWKSL | TYDEVISFVP | 
    360:
    PPLDQEEMES | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    UniGene:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human MAP kinase 14
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    E9114h
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    ELISA Kit for Human MAP kinase 14
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    ELISA Kit for Human MAP kinase 14
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    E9114m
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    ELISA Kit for Human MAP kinase 14
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    E9114r
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    Packing:
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    CLIA Kit for Human MAP kinase 14
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    CLIA Kit for Human MAP kinase 14
    Cat.:
    U9114h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human MAP kinase 14
    Cat.:
    U9114m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MAP kinase 14
    Cat.:
    U9114r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human MAP kinase 14
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    P9114Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MAP kinase 14
    Cat.:
    P9114Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MAP kinase 14
    Polyclonal Antibody for Human MAP kinase 14
    Monoclonal Antibody for Human MAP kinase 14
    Monoclonal Antibody for Human MAP kinase 14
    Monoclonal Antibody for Human MAP kinase 14
    Monoclonal Antibody for Human MAP kinase 14
    Protein for Human MAP kinase 14
    Protein for Human MAP kinase 14
    Protein for Human MAP kinase 14
    Protein for Human MAP kinase 14

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    Precision
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    Recovery
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    Linearity
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    References
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      tissue: Peripheral blood.
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      tissue: B-cell.
    5. 5.
      "Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells."
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      tissue: Renal cell carcinoma.
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    7. 7.
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      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
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    9. 9.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
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    10. 10.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
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    11. 11.
      "The DNA sequence and analysis of human chromosome 6."
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      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
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      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CSBP2)
      tissue: Placenta.
    14. 14.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-10
      tissue: Platelet.
    15. 15.
      "Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27."
      Freshney N.W. , Rawlinson L. , Guesdon F. , Jones E. , Cowley S. , Hsuan J. , Saklatvala J.
      Cell78:1039-1049(1994) [PubMed] [Europe PMC] [Abstract]
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    16. 16.
      "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine."
      Raingeaud J. , Gupta S. , Rogers J.S. , Dickens M. , Han J. , Ulevitch R.J. , Davis R.J.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-180 AND TYR-182;ENZYME REGULATION;SUBCELLULAR LOCATION
    17. 17.
      "Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast."
      Kumar S. , McLaughlin M.M. , McDonnell P.C. , Lee J.C. , Livi G.P. , Young P.R.
      J. Biol. Chem.270:29043-29046(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ALA-34; LYS-53; ASP-168; THR-175; THR-180 AND TYR-182
    18. 18.
      "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."
      Raingeaud J. , Whitmarsh A.J. , Barrett T. , Derijard B. , Davis R.J.
      Mol. Cell. Biol.16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAP2K3/MKK3 AND MAP2K6/MKK6;ENZYME REGULATION
    19. 19.
      "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."
      Deak M. , Clifton A.D. , Lucocq J.M. , Alessi D.R.
      EMBO J.17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF RPS6KA5/MSK1
    20. 20.
      "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
      Enslen H. , Raingeaud J. , Davis R.J.
      J. Biol. Chem.273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP;ENZYME REGULATION
    21. 21.
      "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)."
      Pierrat B. , Correia J.D.S. , Mary J.L. , Tomas-Zuber M. , Lesslauer W.
      J. Biol. Chem.273:29661-29671(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6KA4;FUNCTION IN PHOSPHORYLATION OF RPS6KA4;SUBCELLULAR LOCATION
    22. 22.
      "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5."
      Tanoue T. , Moriguchi T. , Nishida E.
      J. Biol. Chem.274:19949-19956(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP10;ENZYME REGULATION
    23. 23.
      "Regulation of the MEF2 family of transcription factors by p38."
      Zhao M. , New L. , Kravchenko V.V. , Kato Y. , Gram H. , di Padova F. , Olson E.N. , Ulevitch R.J. , Han J.-D.
      Mol. Cell. Biol.19:21-30(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A
    24. 24.
      "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors."
      Yang S.-H. , Galanis A. , Sharrocks A.D.
      Mol. Cell. Biol.19:4028-4038(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A AND MEF2C
    25. 25.
      "Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis."
      Tamura K. , Sudo T. , Senftleben U. , Dadak A.M. , Johnson R. , Karin M.
      Cell102:221-231(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
      tissue: Hepatoma.
    26. 26.
      "Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2."
      Sanz V. , Arozarena I. , Crespo P.
      FEBS Lett.474:169-174(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM MXI2);COFACTOR;ENZYME REGULATION
    27. 27.
      "Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase."
      Sayed M. , Kim S.O. , Salh B.S. , Issinger O.G. , Pelech S.L.
      J. Biol. Chem.275:16569-16573(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK2A1 AND CSNK2B;FUNCTION IN ACTIVATION OF CASEIN KINASE II
    28. 28.
      "Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength."
      Alonso G. , Ambrosino C. , Jones M. , Nebreda A.R.
      J. Biol. Chem.275:40641-40648(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MA2PK6/MKK6;PHOSPHORYLATION BY MAP2K6/MKK6;AUTOPHOSPHORYLATION;MUTAGENESIS OF LYS-54
    29. 29.
      "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1."
      Slack D.N. , Seternes O.M. , Gabrielsen M. , Keyse S.M.
      J. Biol. Chem.276:16491-16500(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP1;ENZYME REGULATION
    30. 30.
      "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs."
      Tanoue T. , Yamamoto T. , Maeda R. , Nishida E.
      J. Biol. Chem.276:26629-26639(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP16;ENZYME REGULATION
    31. 31.
      "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."
      Scheper G.C. , Morrice N.A. , Kleijn M. , Proud C.G.
      Mol. Cell. Biol.21:743-754(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS MKNK2 KINASE
    32. 32.
      "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."
      Bulavin D.V. , Higashimoto Y. , Popoff I.J. , Gaarde W.A. , Basrur V. , Potapova O. , Appella E. , Fornace A.J. Jr.
      Nature411:102-107(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC25B AND CDC25C;FUNCTION IN PHOSPHORYLATION OF CDC25B AND CDC25C
    33. 33.
      "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha."
      Ge B. , Gram H. , Di Padova F. , Huang B. , New L. , Ulevitch R.J. , Luo Y. , Han J.
      Science295:1291-1294(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1;AUTOPHOSPHORYLATION;ENZYME REGULATION
    34. 34.
      "Active mutants of the human p38alpha mitogen-activated protein kinase."
      Diskin R. , Askari N. , Capone R. , Engelberg D. , Livnah O.
      J. Biol. Chem.279:47040-47049(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-69; ASP-176; ASP-177; ALA-320; PHE-327 AND TRP-337
    35. 35.
      "Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils."
      Lominadze G. , Rane M.J. , Merchant M. , Cai J. , Ward R.A. , McLeish K.R.
      J. Immunol.174:7257-7267(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF S100A9
    36. 36.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    37. 37.
      "Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases."
      Salvador J.M. , Mittelstadt P.R. , Guszczynski T. , Copeland T.D. , Yamaguchi H. , Appella E. , Fornace A.J. Jr. , Ashwell J.D.
      Nat. Immunol.6:390-395(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-323;ENZYME REGULATION
    38. 38.
      "The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."
      Salvador J.M. , Mittelstadt P.R. , Belova G.I. , Fornace A.J. Jr. , Ashwell J.D.
      Nat. Immunol.6:396-402(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1;AUTOPHOSPHORYLATION;ENZYME REGULATION
    39. 39.
      "p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation."
      Zohn I.E. , Li Y. , Skolnik E.Y. , Anderson K.V. , Han J. , Niswander L.
      Cell125:957-969(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUPT20H
    40. 40.
      "p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy."
      Zwang Y. , Yarden Y.
      EMBO J.25:4195-4206(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN STRESS-INDUCED INTERNALIZATION OF EGFR
    41. 41.
      "Regulation of the ring finger E3 ligase Siah2 by p38 MAPK."
      Khurana A. , Nakayama K. , Williams S. , Davis R.J. , Mustelin T. , Ronai Z.
      J. Biol. Chem.281:35316-35326(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SIAH2;ENZYME REGULATION
    42. 42.
      "Nuclear protein NP60 regulates p38 MAPK activity."
      Fu J. , Yang Z. , Wei J. , Han J. , Gu J.
      J. Cell Sci.119:115-123(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NP60
    43. 43.
      "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."
      Qi X. , Pohl N.M. , Loesch M. , Hou S. , Li R. , Qin J.Z. , Cuenda A. , Chen G.
      J. Biol. Chem.282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION;UBIQUITINATION
    44. 44.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    45. 45.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    46. 46.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-16;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    47. 47.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    48. 48.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    49. 49.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    50. 50.
      "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."
      Webber J.L. , Tooze S.A.
      EMBO J.29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INHIBITION OF AUTOPHAGY
    51. 51.
      "DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization."
      Reinhardt H.C. , Hasskamp P. , Schmedding I. , Morandell S. , van Vugt M.A. , Wang X. , Linding R. , Ong S.E. , Weaver D. , Carr S.A. , Yaffe M.B.
      Mol. Cell40:34-49(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TIAR
    52. 52.
      "Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."
      Xu P. , Derynck R.
      Mol. Cell37:551-566(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM17;FUNCTION IN PHOSPHORYLATION OF ADAM17
    53. 53.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    54. 54.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    55. 55.
      "Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes."
      Pillai V.B. , Sundaresan N.R. , Samant S.A. , Wolfgeher D. , Trivedi C.M. , Gupta M.P.
      Mol. Cell. Biol.31:2349-2363(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-53 AND LYS-152 BY KAT2B/PCAF AND EP300;DEACETYLATION BY HDAC3
    56. 56.
      "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance."
      Shi Y. , Gaestel M.
      Biol. Chem.383:1519-1536(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    57. 57.
      "Mechanisms and functions of p38 MAPK signalling."
      Cuadrado A. , Nebreda A.R.
      Biochem. J.429:403-417(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
    58. 58.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
    59. 59.
      "A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket."
      Tong L. , Pav S. , White D.M. , Rogers S. , Crane K.M. , Cywin C.L. , Brown M.L. , Pargellis C.A.
      Nat. Struct. Biol.4:311-316(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
    60. 60.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    61. 61.
      "Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase."
      Shewchuk L. , Hassell A. , Wisely B. , Rocque W. , Holmes W. , Veal J. , Kuyper L.F.
      J. Med. Chem.43:133-138(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS)
    62. 62.
      "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site."
      Pargellis C. , Tong L. , Churchill L. , Cirillo P.F. , Gilmore T. , Graham A.G. , Grob P.M. , Hickey E.R. , Moss N. , Pav S. , Regan J.
      Nat. Struct. Biol.9:268-272(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS);ENZYME REGULATION
    63. 63.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS);ENZYME REGULATION
    64. 64.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS);ENZYME REGULATION
    65. 65.
      "Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity."
      Fitzgerald C.E. , Patel S.B. , Becker J.W. , Cameron P.M. , Zaller D. , Pikounis V.B. , O'Keefe S.J. , Scapin G.
      Nat. Struct. Biol.10:764-769(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITOR
    66. 66.
      "Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering."
      Patel S.B. , Cameron P.M. , Frantz-Wattley B. , O'Neill E. , Becker J.W. , Scapin G.
      Biochim. Biophys. Acta1696:67-73(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS);ENZYME REGULATION
    67. 67.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-359 IN COMPLEX WITH INHIBITOR
    68. 68.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-359;ENZYME REGULATION
    69. 69.
      "Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes."
      Michelotti E.L. , Moffett K.K. , Nguyen D. , Kelly M.J. , Shetty R. , Chai X. , Northrop K. , Namboodiri V. , Campbell B. , Flynn G.A. , Fujimoto T. , Hollinger F.P. , Bukhtiyarova M. , Springman E.B. , Karpusas M.
      Bioorg. Med. Chem. Lett.15:5274-5279(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS);ENZYME REGULATION
    70. 70.
      "Fragment-based lead discovery using X-ray crystallography."
      Hartshorn M.J. , Murray C.W. , Cleasby A. , Frederickson M. , Tickle I.J. , Jhoti H.
      J. Med. Chem.48:403-413(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) OF 2-359 IN COMPLEX WITH INHIBITOR
    71. 71.
      "Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer."
      ter Haar E. , Prabhakar P. , Liu X. , Lepre C.
      J. Biol. Chem.282:9733-9739(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 2-359 IN COMPLEX WITH MAPKAPK2
    72. 72.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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