MAPK14 ELISA Kit for Human(Homo sapiens) | EIAab.comMAPK14 ELISA Kit for Human(Homo sapiens)

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MAPK14 (Gene name),

Mitogen-activated protein kinase 14 (Protein name ), MK14_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAPK14(CSBP;CSBP1;CSBP2;CSPB1;MXI2;SAPK2A);

Protein name:

Mitogen-activated protein kinase 14(MAP kinase 14;MAPK 14);

Alternative:

MAP kinase MXI2;Cytokine suppressive anti-inflammatory drug-binding protein(CSAID-binding protein;CSBP);Mitogen-activated protein kinase p38 alpha(MAP kinase p38 alpha);MAX-interacting protein 2;SAPK2A(SAPK2a);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity). Interacts with NP60 and FAM48A.

Function:

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

360

Sequence:

50:

100:

150:

200:

250:

300:

350:

360:

PPLDQEEMES |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q16539

STRING:

9606.ENSP00000229794

SMR:

Q16539

UniGene:

Hs.485233

MIM:

600289

Pfam:

PF00069

KEGG:

hsa:1432

Uniprot:

Q16539

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ELISA Kit for Human MAP kinase 14

Cat.:

E9114h

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96T

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ELISA Kit for Human MAP kinase 14

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ELISA Kit for Human MAP kinase 14

Cat.:

E9114m

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Packing:

96T

ELISA Kit for Human MAP kinase 14

Cat.:

E9114r

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96T

CLIA Kit for Human MAP kinase 14

MSDS:

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CLIA Kit for Human MAP kinase 14

Cat.:

U9114h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human MAP kinase 14

Cat.:

U9114m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human MAP kinase 14

Cat.:

U9114r

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96T

Polyclonal Antibody for Human MAP kinase 14

Cat.:

P9114Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 14

Cat.:

P9114Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MAP kinase 14

Monoclonal Antibody for Human MAP kinase 14

Protein for Human MAP kinase 14

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis."
Lee J.C. , Laydon J.T. , McDonnell P.C. , Gallagher T.F. , Kumar S. , Green D. , McNulty D. , Blumenthal M.J. , Heys R.J. , Landvatter S.W. , Strickler J.E. , McLaughlin M.M. , Siemens I.R. , Fisher S.M. , Livi G.P. , White J.R. , Adams J.L. , Young P.R.
Nature372:739-746(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CSBP1 AND CSBP2);PARTIAL PROTEIN SEQUENCE
tissue: Peripheral blood.
2.

"Molecular cloning of human p38 MAP kinase."
Han J. , Richter B. , Li Z. , Kravchenko V.V. , Ulevitch R.J.
Biochim. Biophys. Acta1265:224-227(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CSBP2)
tissue: Liver.
3.

"Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein."
Zervos A.S. , Faccio L. , Gatto J.P. , Kyriakis J.M. , Brent R.
Proc. Natl. Acad. Sci. U.S.A.92:10531-10534(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MXI2)
4.

"Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4."
Herbison C.E. , Sayer D.C. , Bellgard M. , Allcock R.J.N. , Christiansen F.T. , Price P.
DNA Seq.10:229-243(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CSBP2)
tissue: B-cell.
5.

"Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells."
Sudo T. , Yagasaki Y. , Hama H. , Watanabe N. , Osada H.
Biochem. Biophys. Res. Commun.291:838-843(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EXIP);ENZYME REGULATION
tissue: Renal cell carcinoma.
6.

"Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
Wang P. , Yu P. , Gao P. , Shi T. , Ma D.
BMC Genomics10:518-518(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CSBP2)
9.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CSBP2)
10.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
11.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CSBP2)
tissue: Placenta.
14.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-10
tissue: Platelet.
15.

"Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27."
Freshney N.W. , Rawlinson L. , Guesdon F. , Jones E. , Cowley S. , Hsuan J. , Saklatvala J.
Cell78:1039-1049(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 174-186
16.

"Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine."
Raingeaud J. , Gupta S. , Rogers J.S. , Dickens M. , Han J. , Ulevitch R.J. , Davis R.J.
J. Biol. Chem.270:7420-7426(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-180 AND TYR-182;ENZYME REGULATION;SUBCELLULAR LOCATION
17.

"Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast."
Kumar S. , McLaughlin M.M. , McDonnell P.C. , Lee J.C. , Livi G.P. , Young P.R.
J. Biol. Chem.270:29043-29046(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ALA-34; LYS-53; ASP-168; THR-175; THR-180 AND TYR-182
18.

"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."
Raingeaud J. , Whitmarsh A.J. , Barrett T. , Derijard B. , Davis R.J.
Mol. Cell. Biol.16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAP2K3/MKK3 AND MAP2K6/MKK6;ENZYME REGULATION
19.

"Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."
Deak M. , Clifton A.D. , Lucocq J.M. , Alessi D.R.
EMBO J.17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF RPS6KA5/MSK1
20.

"Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
Enslen H. , Raingeaud J. , Davis R.J.
J. Biol. Chem.273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ATF2; ELK1 AND MBP;ENZYME REGULATION
21.

"RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)."
Pierrat B. , Correia J.D.S. , Mary J.L. , Tomas-Zuber M. , Lesslauer W.
J. Biol. Chem.273:29661-29671(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RPS6KA4;FUNCTION IN PHOSPHORYLATION OF RPS6KA4;SUBCELLULAR LOCATION
22.

"Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5."
Tanoue T. , Moriguchi T. , Nishida E.
J. Biol. Chem.274:19949-19956(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP10;ENZYME REGULATION
23.

"Regulation of the MEF2 family of transcription factors by p38."
Zhao M. , New L. , Kravchenko V.V. , Kato Y. , Gram H. , di Padova F. , Olson E.N. , Ulevitch R.J. , Han J.-D.
Mol. Cell. Biol.19:21-30(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A
24.

"Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors."
Yang S.-H. , Galanis A. , Sharrocks A.D.
Mol. Cell. Biol.19:4028-4038(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MEF2A AND MEF2C
25.

"Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis."
Tamura K. , Sudo T. , Senftleben U. , Dadak A.M. , Johnson R. , Karin M.
Cell102:221-231(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
tissue: Hepatoma.
26.

"Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2."
Sanz V. , Arozarena I. , Crespo P.
FEBS Lett.474:169-174(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM MXI2);COFACTOR;ENZYME REGULATION
27.

"Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase."
Sayed M. , Kim S.O. , Salh B.S. , Issinger O.G. , Pelech S.L.
J. Biol. Chem.275:16569-16573(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK2A1 AND CSNK2B;FUNCTION IN ACTIVATION OF CASEIN KINASE II
28.

"Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength."
Alonso G. , Ambrosino C. , Jones M. , Nebreda A.R.
J. Biol. Chem.275:40641-40648(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MA2PK6/MKK6;PHOSPHORYLATION BY MAP2K6/MKK6;AUTOPHOSPHORYLATION;MUTAGENESIS OF LYS-54
29.

"Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1."
Slack D.N. , Seternes O.M. , Gabrielsen M. , Keyse S.M.
J. Biol. Chem.276:16491-16500(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP1;ENZYME REGULATION
30.

"A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs."
Tanoue T. , Yamamoto T. , Maeda R. , Nishida E.
J. Biol. Chem.276:26629-26639(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUSP16;ENZYME REGULATION
31.

"The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells."
Scheper G.C. , Morrice N.A. , Kleijn M. , Proud C.G.
Mol. Cell. Biol.21:743-754(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS MKNK2 KINASE
32.

"Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase."
Bulavin D.V. , Higashimoto Y. , Popoff I.J. , Gaarde W.A. , Basrur V. , Potapova O. , Appella E. , Fornace A.J. Jr.
Nature411:102-107(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC25B AND CDC25C;FUNCTION IN PHOSPHORYLATION OF CDC25B AND CDC25C
33.

"MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha."
Ge B. , Gram H. , Di Padova F. , Huang B. , New L. , Ulevitch R.J. , Luo Y. , Han J.
Science295:1291-1294(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1;AUTOPHOSPHORYLATION;ENZYME REGULATION
34.

"Active mutants of the human p38alpha mitogen-activated protein kinase."
Diskin R. , Askari N. , Capone R. , Engelberg D. , Livnah O.
J. Biol. Chem.279:47040-47049(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-69; ASP-176; ASP-177; ALA-320; PHE-327 AND TRP-337
35.

"Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils."
Lominadze G. , Rane M.J. , Merchant M. , Cai J. , Ward R.A. , McLeish K.R.
J. Immunol.174:7257-7267(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF S100A9
36.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
37.

"Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases."
Salvador J.M. , Mittelstadt P.R. , Guszczynski T. , Copeland T.D. , Yamaguchi H. , Appella E. , Fornace A.J. Jr. , Ashwell J.D.
Nat. Immunol.6:390-395(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-323;ENZYME REGULATION
38.

"The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway."
Salvador J.M. , Mittelstadt P.R. , Belova G.I. , Fornace A.J. Jr. , Ashwell J.D.
Nat. Immunol.6:396-402(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TAB1;AUTOPHOSPHORYLATION;ENZYME REGULATION
39.

"p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation."
Zohn I.E. , Li Y. , Skolnik E.Y. , Anderson K.V. , Han J. , Niswander L.
Cell125:957-969(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUPT20H
40.

"p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy."
Zwang Y. , Yarden Y.
EMBO J.25:4195-4206(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN STRESS-INDUCED INTERNALIZATION OF EGFR
41.

"Regulation of the ring finger E3 ligase Siah2 by p38 MAPK."
Khurana A. , Nakayama K. , Williams S. , Davis R.J. , Mustelin T. , Ronai Z.
J. Biol. Chem.281:35316-35326(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SIAH2;ENZYME REGULATION
42.

"Nuclear protein NP60 regulates p38 MAPK activity."
Fu J. , Yang Z. , Wei J. , Han J. , Gu J.
J. Cell Sci.119:115-123(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NP60
43.

"p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."
Qi X. , Pohl N.M. , Loesch M. , Hou S. , Li R. , Qin J.Z. , Cuenda A. , Chen G.
J. Biol. Chem.282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION;UBIQUITINATION
44.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
45.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
46.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-16;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
47.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
48.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
49.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
50.

"Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."
Webber J.L. , Tooze S.A.
EMBO J.29:27-40(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INHIBITION OF AUTOPHAGY
51.

"DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization."
Reinhardt H.C. , Hasskamp P. , Schmedding I. , Morandell S. , van Vugt M.A. , Wang X. , Linding R. , Ong S.E. , Weaver D. , Carr S.A. , Yaffe M.B.
Mol. Cell40:34-49(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TIAR
52.

"Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."
Xu P. , Derynck R.
Mol. Cell37:551-566(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM17;FUNCTION IN PHOSPHORYLATION OF ADAM17
53.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-180 AND TYR-182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
54.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
55.

"Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes."
Pillai V.B. , Sundaresan N.R. , Samant S.A. , Wolfgeher D. , Trivedi C.M. , Gupta M.P.
Mol. Cell. Biol.31:2349-2363(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-53 AND LYS-152 BY KAT2B/PCAF AND EP300;DEACETYLATION BY HDAC3
56.

"In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance."
Shi Y. , Gaestel M.
Biol. Chem.383:1519-1536(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
57.

"Mechanisms and functions of p38 MAPK signalling."
Cuadrado A. , Nebreda A.R.
Biochem. J.429:403-417(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
58.

"Crystal structure of p38 mitogen-activated protein kinase."
Wilson K.P. , Fitzgibbon M.J. , Caron P.R. , Griffith J.P. , Chen W. , McCaffrey P.G. , Chambers S.P. , Su M.S.-S.
J. Biol. Chem.271:27696-27700(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
59.

"A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket."
Tong L. , Pav S. , White D.M. , Rogers S. , Crane K.M. , Cywin C.L. , Brown M.L. , Pargellis C.A.
Nat. Struct. Biol.4:311-316(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
60.

"Structural basis of inhibitor selectivity in MAP kinases."
Wang Z. , Canagarajah B.J. , Boehm J.C. , Kassisa S. , Cobb M.H. , Young P.R. , Abdel-Meguid S. , Adams J.L. , Goldsmith E.J.
Structure6:1117-1128(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
61.

"Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase."
Shewchuk L. , Hassell A. , Wisely B. , Rocque W. , Holmes W. , Veal J. , Kuyper L.F.
J. Med. Chem.43:133-138(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS)
62.

"Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site."
Pargellis C. , Tong L. , Churchill L. , Cirillo P.F. , Gilmore T. , Graham A.G. , Grob P.M. , Hickey E.R. , Moss N. , Pav S. , Regan J.
Nat. Struct. Biol.9:268-272(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS);ENZYME REGULATION
63.

"Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase."
Stelmach J.E. , Liu L. , Patel S.B. , Pivnichny J.V. , Scapin G. , Singh S. , Hop C.E. , Wang Z. , Strauss J.R. , Cameron P.M. , Nichols E.A. , O'Keefe S.J. , O'Neill E.A. , Schmatz D.M. , Schwartz C.D. , Thompson C.M. , Zaller D.M. , Doherty J.B.
Bioorg. Med. Chem. Lett.13:277-280(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS);ENZYME REGULATION
64.

"Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase."
Trejo A. , Arzeno H. , Browner M. , Chanda S. , Cheng S. , Comer D.D. , Dalrymple S.A. , Dunten P. , Lafargue J. , Lovejoy B. , Freire-Moar J. , Lim J. , Mcintosh J. , Miller J. , Papp E. , Reuter D. , Roberts R. , Sanpablo F. , more...
J. Med. Chem.46:4702-4713(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS);ENZYME REGULATION
65.

"Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity."
Fitzgerald C.E. , Patel S.B. , Becker J.W. , Cameron P.M. , Zaller D. , Pikounis V.B. , O'Keefe S.J. , Scapin G.
Nat. Struct. Biol.10:764-769(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITOR
66.

"Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering."
Patel S.B. , Cameron P.M. , Frantz-Wattley B. , O'Neill E. , Becker J.W. , Scapin G.
Biochim. Biophys. Acta1696:67-73(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS);ENZYME REGULATION
67.

"Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase."
Sullivan J.E. , Holdgate G.A. , Campbell D. , Timms D. , Gerhardt S. , Breed J. , Breeze A.L. , Bermingham A. , Pauptit R.A. , Norman R.A. , Embrey K.J. , Read J. , VanScyoc W.S. , Ward W.H.
Biochemistry44:16475-16490(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 2-359 IN COMPLEX WITH INHIBITOR
68.

"Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase."
Tamayo N. , Liao L. , Goldberg M. , Powers D. , Tudor Y.Y. , Yu V. , Wong L.M. , Henkle B. , Middleton S. , Syed R. , Harvey T. , Jang G. , Hungate R. , Dominguez C.
Bioorg. Med. Chem. Lett.15:2409-2413(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-359;ENZYME REGULATION
69.

"Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes."
Michelotti E.L. , Moffett K.K. , Nguyen D. , Kelly M.J. , Shetty R. , Chai X. , Northrop K. , Namboodiri V. , Campbell B. , Flynn G.A. , Fujimoto T. , Hollinger F.P. , Bukhtiyarova M. , Springman E.B. , Karpusas M.
Bioorg. Med. Chem. Lett.15:5274-5279(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS);ENZYME REGULATION
70.

"Fragment-based lead discovery using X-ray crystallography."
Hartshorn M.J. , Murray C.W. , Cleasby A. , Frederickson M. , Tickle I.J. , Jhoti H.
J. Med. Chem.48:403-413(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS) OF 2-359 IN COMPLEX WITH INHIBITOR
71.

"Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer."
ter Haar E. , Prabhakar P. , Liu X. , Lepre C.
J. Biol. Chem.282:9733-9739(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 2-359 IN COMPLEX WITH MAPKAPK2
72.

ter Haar E. , Prabhakar P. , Liu X. , Lepre C.
J. Biol. Chem.282:14684-14684(2007)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
73.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-51; ARG-322 AND GLY-343

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