MAP1LC3B ELISA Kit for Human(Homo sapiens) | EIAab.comMAP1LC3B ELISA Kit for Human(Homo sapiens)

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MAP1LC3B (Gene name),

Microtubule-associated proteins 1A/1B light chain 3B (Protein name ), MLP3B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAP1LC3B(MAP1ALC3);

Protein name:

Microtubule-associated proteins 1A/1B light chain 3B;

Alternative:

Autophagy-related ubiquitin-like modifier LC3 B;Autophagy-related protein LC3 B;MAP1A/MAP1B light chain 3 B(MAP1A/MAP1B LC3 B);MAP1 light chain 3-like protein 2;Microtubule-associated protein 1 light chain 3 beta;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus).

Function:

Probably involved in formation of autophagosomal vacuoles (autophagosomes).

Subcellular Location:

Cytoplasm cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle autophagosome membrane Lipid-anchor LC3-II binds to the autophagic membranes.

Protein Attributes:

Sequence length:

125

Sequence:

50:

100:

125:

SEKDEDGFLY | MVYASQETFG | MKLSV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

609604

SMR:

Q9GZQ8

UniGene:

Hs.356061

STRING:

9606.ENSP00000268607

Pfam:

PF02991

KEGG:

hsa:81631

String:

Q9GZQ8

Uniprot:

Q9GZQ8

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ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

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E2880r

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ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

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E2880b

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96T

ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

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E2880h

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ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

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E2880m

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96T

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CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

U2880m

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96T

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CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

U2880r

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Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

U2880b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

U2880h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

P2880Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

P2880Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B

Cat.:

P2880Rb-r

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Packing:

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Monoclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B

Protein for Human Microtubule-associated proteins 1A/1B light chain 3B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Gene expression profiles in human non-small and small-cell lung cancers."
Difilippantonio S. , Chen Y. , Pietas A. , Schluens K. , Pacyna-Gengelbach M. , Deutschmann N. , Padilla-Nash H.M. , Ried T. , Petersen I.
Eur. J. Cancer39:1936-1947(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung carcinoma.
2.

"The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning."
Yang Y.-S. , Song H.-D. , Peng Y.-D. , Huang Q.-H. , Li R.-Y. , Zhu Z.-D. , Hu R.-M. , Han Z.-G. , Chen J.-L.
Endocr. Relat. Cancer10:621-627(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pheochromocytoma.
3.

"Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B."
He H. , Dang Y. , Dai F. , Guo Z. , Wu J. , She X. , Pei Y. , Chen Y. , Ling W. , Wu C. , Zhao S. , Liu J.O. , Yu L.
J. Biol. Chem.278:29278-29287(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;CLEAVAGE;TISSUE SPECIFICITY
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Hepatoma.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Pancreas.
tissue: Testis.
6.

"HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
Tanida I. , Sou Y.-S. , Ezaki J. , Minematsu-Ikeguchi N. , Ueno T. , Kominami E.
J. Biol. Chem.279:36268-36276(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIPIDATION AT GLY-120;CLEAVAGE BY ATG4B
7.

"Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes."
Tanida I. , Ueno T. , Kominami E.
J. Biol. Chem.279:47704-47710(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE;MUTAGENESIS OF GLY-120 AND LYS-122
8.

"LC3 conjugation system in mammalian autophagy."
Tanida I. , Ueno T. , Kominami E.
Int. J. Biochem. Cell Biol.36:2503-2518(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
9.

"Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
Seidenbecher C.I. , Landwehr M. , Smalla K.H. , Kreutz M. , Dieterich D.C. , Zuschratter W. , Reissner C. , Hammarback J.A. , Bockers T.M. , Gundelfinger E.D. , Kreutz M.R.
J. Mol. Biol.336:957-970(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CABP1
10.

"p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
Pankiv S. , Clausen T.H. , Lamark T. , Brech A. , Bruun J.A. , Outzen H. , Overvatn A. , Bjorkoy G. , Johansen T.
J. Biol. Chem.282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1;SUBCELLULAR LOCATION
11.

"LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."
Weidberg H. , Shvets E. , Shpilka T. , Shimron F. , Shinder V. , Elazar Z.
EMBO J.29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."
Pankiv S. , Alemu E.A. , Brech A. , Bruun J.A. , Lamark T. , Overvatn A. , Bjorkoy G. , Johansen T.
J. Cell Biol.188:253-269(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FYCO1
13.

"Network organization of the human autophagy system."
Behrends C. , Sowa M.E. , Gygi S.P. , Harper J.W.
Nature466:68-76(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR2;MUTAGENESIS OF 52-PHE-LYS-53 AND ARG-70
14.

"OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
Itoh T. , Kanno E. , Uemura T. , Waguri S. , Fukuda M.
J. Cell Biol.192:839-853(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D25
15.

"MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins."
Colecchia D. , Strambi A. , Sanzone S. , Iavarone C. , Rossi M. , Dall'Armi C. , Piccioni F. , Verrotti di Pianella A. , Chiariello M.
Autophagy8:1724-1740(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK15;PHOSPHORYLATION
16.

"Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens."
Dengjel J. , Hoyer-Hansen M. , Nielsen M.O. , Eisenberg T. , Harder L.M. , Schandorff S. , Farkas T. , Kirkegaard T. , Becker A.C. , Schroeder S. , Vanselow K. , Lundberg E. , Nielsen M.M. , Kristensen A.R. , Akimov V. , Bunkenborg J. , Madeo F. , Jaattela M. , more...
Mol. Cell. Proteomics11:M111.014035.1-M111.014035.17(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
17.

"Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."
Popovic D. , Akutsu M. , Novak I. , Harper J.W. , Behrends C. , Dikic I.
Mol. Cell. Biol.32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D5
18.

"DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
Sancho A. , Duran J. , Garcia-Espana A. , Mauvezin C. , Alemu E.A. , Lamark T. , Macias M.J. , Desalle R. , Royo M. , Sala D. , Chicote J.U. , Palacin M. , Johansen T. , Zorzano A.
PLoS ONE7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53INP1 AND TP53INP2
19.

"The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."
Choy A. , Dancourt J. , Mugo B. , O'Connor T.J. , Isberg R.R. , Melia T.J. , Roy C.R.
Science338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DECONJUGATION BY LEGIONELLA RAVZ
20.

"Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins."
Liu C. , Ma H. , Wu J. , Huang Q. , Liu J.O. , Yu L.
BMC Cell Biol.14:27-27(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-68;CLEAVAGE BY ATG4B
21.

"Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."
Zhu Y. , Massen S. , Terenzio M. , Lang V. , Chen-Lindner S. , Eils R. , Novak I. , Dikic I. , Hamacher-Brady A. , Brady N.R.
J. Biol. Chem.288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BNIP3;FUNCTION
22.

"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
Tang Z. , Lin M.G. , Stowe T.R. , Chen S. , Zhu M. , Stearns T. , Franco B. , Zhong Q.
Nature502:254-257(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPB1; FYCO1; SQSTM1; KEAP1; PCM1; OFD1 AND CEP131;FUNCTION
23.

"Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains."
Kouno T. , Mizuguchi M. , Tanida I. , Ueno T. , Kanematsu T. , Mori Y. , Shinoda H. , Hirata M. , Kominami E. , Kawano K.
J. Biol. Chem.280:24610-24617(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-120
24.

"Structural basis for sorting mechanism of p62 in selective autophagy."
Ichimura Y. , Kumanomidou T. , Sou Y.S. , Mizushima T. , Ezaki J. , Ueno T. , Kominami E. , Yamane T. , Tanaka K. , Komatsu M.
J. Biol. Chem.283:22847-22857(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH AN LC3 RECOGNITION SEQUENCE (LRS)

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