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Index > Protein center > MAP1LC3B(Gene name) > Human
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  • MAP1LC3B (Gene name),
  • Microtubule-associated proteins 1A/1B light chain 3B (Protein name ),  MLP3B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAP1LC3B(MAP1ALC3);
    Protein name:
    Microtubule-associated proteins 1A/1B light chain 3B;
    Alternative:
    Autophagy-related ubiquitin-like modifier LC3 B;Autophagy-related protein LC3 B;MAP1A/MAP1B light chain 3 B(MAP1A/MAP1B LC3 B);MAP1 light chain 3-like protein 2;Microtubule-associated protein 1 light chain 3 beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus).
    Function:
    Probably involved in formation of autophagosomal vacuoles (autophagosomes).
    Subcellular Location:
    Cytoplasm cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle autophagosome membrane Lipid-anchor LC3-II binds to the autophagic membranes.
    Protein Attributes:
    Sequence length:
    125
    Sequence:
    50:
    MPSEKTFKQR | RTFEQRVEDV | RLIREQHPTK | IPVIIERYKG | EKQLPVLDKT | 
    100:
    KFLVPDHVNM | SELIKIIRRR | LQLNANQAFF | LLVNGHSMVS | VSTPISEVYE | 
    125:
    SEKDEDGFLY | MVYASQETFG | MKLSV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    E2880r
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    ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    E2880b
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    ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    E2880h
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    ELISA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    E2880m
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    CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    U2880m
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    96T
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    CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    U2880r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    U2880b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Microtubule-associated proteins 1A/1B light chain 3B
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    U2880h
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    Packing:
    96T
    Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    P2880Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
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    P2880Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Polyclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Cat.:
    P2880Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Monoclonal Antibody for Human Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Human Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Human Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Human Microtubule-associated proteins 1A/1B light chain 3B
    Protein for Human Microtubule-associated proteins 1A/1B light chain 3B

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    References
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      tissue: Brain.
      tissue: Pancreas.
      tissue: Testis.
    6. 6.
      "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
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      "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes."
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    9. 9.
      "Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
      Seidenbecher C.I. , Landwehr M. , Smalla K.H. , Kreutz M. , Dieterich D.C. , Zuschratter W. , Reissner C. , Hammarback J.A. , Bockers T.M. , Gundelfinger E.D. , Kreutz M.R.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CABP1
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      "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1;SUBCELLULAR LOCATION
    11. 11.
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      EMBO J.29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."
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      J. Cell Biol.188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
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      "Network organization of the human autophagy system."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR2;MUTAGENESIS OF 52-PHE-LYS-53 AND ARG-70
    14. 14.
      "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D25
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      "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins."
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    16. 16.
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    18. 18.
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    19. 19.
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      Science338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DECONJUGATION BY LEGIONELLA RAVZ
    20. 20.
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      Liu C. , Ma H. , Wu J. , Huang Q. , Liu J.O. , Yu L.
      BMC Cell Biol.14:27-27(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-68;CLEAVAGE BY ATG4B
    21. 21.
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      J. Biol. Chem.288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BNIP3;FUNCTION
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      Nature502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPB1; FYCO1; SQSTM1; KEAP1; PCM1; OFD1 AND CEP131;FUNCTION
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-120
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      Ichimura Y. , Kumanomidou T. , Sou Y.S. , Mizushima T. , Ezaki J. , Ueno T. , Kominami E. , Yamane T. , Tanaka K. , Komatsu M.
      J. Biol. Chem.283:22847-22857(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH AN LC3 RECOGNITION SEQUENCE (LRS)
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