MMP13 ELISA Kit for Human(Homo sapiens) | EIAab.comMMP13 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MMP13(Gene name) > Human

MMP13 (Gene name),

Collagenase 3 (Protein name ), MMP13_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

MMP13;

Protein name:

Collagenase 3;

Alternative:

Matrix metalloproteinase-13(MMP-13);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

471

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

471:

EYSIWSNRIV | RVMPANSILW | C

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

SMR:

P45452

String:

P45452

MIM:

600108

Pfam:

PF00045

UniGene:

Hs.2936

KEGG:

hsa:4322

STRING:

9606.ENSP00000260302

Uniprot:

P45452

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ELISA Kit for Human Collagenase 3

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E0099m

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96T

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ELISA Kit for Human Collagenase 3

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E0099h

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ELISA Kit for Human Collagenase 3

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E0099r

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ELISA Kit for Human Collagenase 3

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ELISA Kit for Human Collagenase 3

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E0099b

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CLIA Kit for Human Collagenase 3

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CLIA Kit for Human Collagenase 3

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U0099r

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96T

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CLIA Kit for Human Collagenase 3

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U0099h

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96T

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CLIA Kit for Human Collagenase 3

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U0099m

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CLIA Kit for Human Collagenase 3

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U0099b

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Polyclonal Antibody for Human Collagenase 3

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P0099Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Collagenase 3

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P0099Rb-r

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Polyclonal Antibody for Human Collagenase 3

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P0099Rb-h

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Polyclonal Antibody for Human Collagenase 3

Monoclonal Antibody for Human Collagenase 3

Protein for Human Collagenase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"The protective effect of xanthan gum on interleukin-1β induced rabbit chondrocytes"

G Han, H Shao, X Zhu, et al.

From:Carbohydrate Polymers

References

1.

"Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas."
Freije J.M.P. , Diez-Itza I. , Balbin M. , Sanchez L.M. , Blasco R. , Tolivia J. , Lopez-Otin C.
J. Biol. Chem.269:16766-16773(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;FUNCTION;TISSUE SPECIFICITY
tissue: Mammary carcinoma.
2.

"A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas."
Willmroth F. , Peter H.H. , Conca W.
Immunobiology198:375-384(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Esophagus.
tissue: Synovium.
4.

NIEHS SNPs program
Submitted (2004-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-390
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
6.

"Biochemical characterization of human collagenase-3."
Knaeuper V. , Lopez-Otin C. , Smith B. , Knight G. , Murphy G.
J. Biol. Chem.271:1544-1550(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-27 AND 104-118;PROPEPTIDE;AUTOCATALYTIC PROCESSING;CATALYTIC ACTIVITY;FUNCTION;GLYCOSYLATION AT ASN-117;SUBCELLULAR LOCATION;ENZYME REGULATION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3
7.

"Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme."
Knaeuper V. , Will H. , Lopez-Otin C. , Smith B. , Atkinson S.J. , Stanton H. , Hembry R.M. , Murphy G.
J. Biol. Chem.271:17124-17131(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PROPEPTIDE;FUNCTION;CATALYTIC ACTIVITY
8.

"Degradation of cartilage aggrecan by collagenase-3 (MMP-13)."
Fosang A.J. , Last K. , Knaeuper V. , Murphy G. , Neame P.J.
FEBS Lett.380:17-20(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes."
Borden P. , Solymar D. , Sucharczuk A. , Lindman B. , Cannon P. , Heller R.A.
J. Biol. Chem.271:23577-23581(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY
10.

"Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."
Johansson N. , Saarialho-Kere U. , Airola K. , Herva R. , Nissinen L. , Westermarck J. , Vuorio E. , Heino J. , Kaehaeri V.M.
Dev. Dyn.208:387-397(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION BY TGFB1
11.

"The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction."
Knaeuper V. , Cowell S. , Smith B. , Lopez-Otin C. , O'Shea M. , Morris H. , Zardi L. , Murphy G.
J. Biol. Chem.272:7608-7616(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;CATALYTIC ACTIVITY;AUTOCATALYTIC PROCESSING;FUNCTION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3;ENZYME REGULATION
12.

"A secreted tyrosine kinase acts in the extracellular environment."
Bordoli M.R. , Yum J. , Breitkopf S.B. , Thon J.N. , Italiano J.E. Jr. , Xiao J. , Worby C. , Wong S.K. , Lin G. , Edenius M. , Keller T.L. , Asara J.M. , Dixon J.E. , Yeo C.Y. , Whitman M.
Cell158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-366
13.

"The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain."
Gomis-Rueth F.-X. , Gohlke U. , Betz M. , Knaeuper V. , Murphy G. , Lopez-Otin C. , Bode W.
J. Mol. Biol.264:556-566(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 265-471 IN COMPLEX WITH CALCIUM;DISULFIDE BOND
14.

"Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."
Lovejoy B. , Welch A.R. , Carr S. , Luong C. , Broka C. , Hendricks R.T. , Campbell J.A. , Walker K.A. , Martin R. , Van Wart H. , Browner M.F.
Nat. Struct. Biol.6:217-221(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 104-271 IN COMPLEXES WITH SYNTHETIC INHIBITORS; CALCIUM AND ZINC;PROPEPTIDE;AUTOCATALYTIC PROCESSING
15.

"Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1."
Zhang X. , Gonnella N.C. , Koehn J. , Pathak N. , Ganu V. , Melton R. , Parker D. , Hu S.I. , Nam K.Y.
J. Mol. Biol.301:513-524(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC
16.

"High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor."
Moy F.J. , Chanda P.K. , Chen J.M. , Cosmi S. , Edris W. , Levin J.I. , Powers R.
J. Mol. Biol.302:671-689(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 104-268 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY
17.

"Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14."
Blagg J.A. , Noe M.C. , Wolf-Gouveia L.A. , Reiter L.A. , Laird E.R. , Chang S.P. , Danley D.E. , Downs J.T. , Elliott N.C. , Eskra J.D. , Griffiths R.J. , Hardink J.R. , Haugeto A.I. , Jones C.S. , Liras J.L. , Lopresti-Morrow L.L. , Mitchell P.G. , Pandit J. , more...
Bioorg. Med. Chem. Lett.15:1807-1810(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 104-271 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
18.

"Structural basis for the highly selective inhibition of MMP-13."
Engel C.K. , Pirard B. , Schimanski S. , Kirsch R. , Habermann J. , Klingler O. , Schlotte V. , Weithmann K.U. , Wendt K.U.
Chem. Biol.12:181-189(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
19.

"Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."
Johnson A.R. , Pavlovsky A.G. , Ortwine D.F. , Prior F. , Man C.F. , Bornemeier D.A. , Banotai C.A. , Mueller W.T. , McConnell P. , Yan C. , Baragi V. , Lesch C. , Roark W.H. , Wilson M. , Datta K. , Guzman R. , Han H.K. , Dyer R.D.
J. Biol. Chem.282:27781-27791(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION IN CARTILAGE DEGRADATION
20.

"Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."
Maskos K. , Lang R. , Tschesche H. , Bode W.
J. Mol. Biol.366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 104-268 IN COMPLEX WITH TIMP2; CALCIUM AND ZINC;INTERACTION WITH TIMP2
21.

"Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13."
Monovich L.G. , Tommasi R.A. , Fujimoto R.A. , Blancuzzi V. , Clark K. , Cornell W.D. , Doti R. , Doughty J. , Fang J. , Farley D. , Fitt J. , Ganu V. , Goldberg R. , Goldstein R. , Lavoie S. , Kulathila R. , Macchia W. , Parker D.T. , more...
J. Med. Chem.52:3523-3538(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
22.

"Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis."
Schnute M.E. , O'Brien P.M. , Nahra J. , Morris M. , Howard Roark W. , Hanau C.E. , Ruminski P.G. , Scholten J.A. , Fletcher T.R. , Hamper B.C. , Carroll J.N. , Patt W.C. , Shieh H.S. , Collins B. , Pavlovsky A.G. , Palmquist K.E. , Aston K.W. , Hitchcock J. , more...
Bioorg. Med. Chem. Lett.20:576-580(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR
23.

"Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease."
Becker D.P. , Barta T.E. , Bedell L.J. , Boehm T.L. , Bond B.R. , Carroll J. , Carron C.P. , Decrescenzo G.A. , Easton A.M. , Freskos J.N. , Funckes-Shippy C.L. , Heron M. , Hockerman S. , Howard C.P. , Kiefer J.R. , Li M.H. , Mathis K.J. , McDonald J.J. , more...
J. Med. Chem.53:6653-6680(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-267 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
24.

"Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins."
Devel L. , Beau F. , Amoura M. , Vera L. , Cassar-Lajeunesse E. , Garcia S. , Czarny B. , Stura E.A. , Dive V.
J. Biol. Chem.287:26647-26656(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS) OF 104-272 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
25.

"Hydantoin based inhibitors of MMP13--discovery of AZD6605."
De Savi C. , Waterson D. , Pape A. , Lamont S. , Hadley E. , Mills M. , Page K.M. , Bowyer J. , Maciewicz R.A.
Bioorg. Med. Chem. Lett.23:4705-4712(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 103-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION
26.

"Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain."
Stura E.A. , Visse R. , Cuniasse P. , Dive V. , Nagase H.
FASEB J.27:4395-4405(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 104-471 OF MUTANT ALA-223 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;DISULFIDE BOND;MUTAGENESIS OF GLU-223;ACTIVE SITE;SUBUNIT
27.

"MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."
Kennedy A.M. , Inada M. , Krane S.M. , Christie P.T. , Harding B. , Lopez-Otin C. , Sanchez L.M. , Pannett A.A.J. , Dearlove A. , Hartley C. , Byrne M.H. , Reed A.A.C. , Nesbit M.A. , Whyte M.P. , Thakker R.V.
J. Clin. Invest.115:2832-2842(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SEMD-MO SER-75;CHARACTERIZATION OF VARIANT SEMD-MO SER-75;FUNCTION IN BONE DEVELOPMENT
28.

"Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."
Lausch E. , Keppler R. , Hilbert K. , Cormier-Daire V. , Nikkel S. , Nishimura G. , Unger S. , Spranger J. , Superti-Furga A. , Zabel B.
Am. J. Hum. Genet.85:168-178(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANDP1 SER-74; THR-91 AND ASN-232;FUNCTION IN BONE DEVELOPMENT

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