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Index > Protein center > MRC1(Gene name) > Human
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  • MRC1 (Gene name),
  • Macrophage mannose receptor 1 (Protein name ),  MRC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    MRC1(CLEC13D;CLEC13DL;MRC1L1);
    Protein name:
    Macrophage mannose receptor 1(MMR);
    Alternative:
    C-type lectin domain family 13 member D-like;C-type lectin domain family 13 member D;Macrophage mannose receptor 1-like protein 1;
    CD:
    CD206;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
    Subcellular Location:
    Endosome membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1456
    Sequence:
    50:
    MRLPLLLVFA | SVIPGAVLLL | DTRQFLIYNE | DHKRCVDAVS | PSAVQTAACN | 
    100:
    QDAESQKFRW | VSESQIMSVA | FKLCLGVPSK | TDWVAITLYA | CDSKSEFQKW | 
    150:
    ECKNDTLLGI | KGEDLFFNYG | NRQEKNIMLY | KGSGLWSRWK | IYGTTDNLCS | 
    200:
    RGYEAMYTLL | GNANGATCAF | PFKFENKWYA | DCTSAGRSDG | WLWCGTTTDY | 
    250:
    DTDKLFGYCP | LKFEGSESLW | NKDPLTSVSY | QINSKSALTW | HQARKSCQQQ | 
    300:
    NAELLSITEI | HEQTYLTGLT | SSLTSGLWIG | LNSLSFNSGW | QWSDRSPFRY | 
    350:
    LNWLPGSPSA | EPGKSCVSLN | PGKNAKWENL | ECVQKLGYIC | KKGNTTLNSF | 
    400:
    VIPSESDVPT | HCPSQWWPYA | GHCYKIHRDE | KKIQRDALTT | CRKEGGDLTS | 
    450:
    IHTIEELDFI | ISQLGYEPND | ELWIGLNDIK | IQMYFEWSDG | TPVTFTKWLR | 
    500:
    GEPSHENNRQ | EDCVVMKGKD | GYWADRGCEW | PLGYICKMKS | RSQGPEIVEV | 
    550:
    EKGCRKGWKK | HHFYCYMIGH | TLSTFAEANQ | TCNNENAYLT | TIEDRYEQAF | 
    600:
    LTSFVGLRPE | KYFWTGLSDI | QTKGTFQWTI | EEEVRFTHWN | SDMPGRKPGC | 
    650:
    VAMRTGIAGG | LWDVLKCDEK | AKFVCKHWAE | GVTHPPKPTT | TPEPKCPEDW | 
    700:
    GASSRTSLCF | KLYAKGKHEK | KTWFESRDFC | RALGGDLASI | NNKEEQQTIW | 
    750:
    RLITASGSYH | KLFWLGLTYG | SPSEGFTWSD | GSPVSYENWA | YGEPNNYQNV | 
    800:
    EYCGELKGDP | TMSWNDINCE | HLNNWICQIQ | KGQTPKPEPT | PAPQDNPPVT | 
    850:
    EDGWVIYKDY | QYYFSKEKET | MDNARAFCKR | NFGDLVSIQS | ESEKKFLWKY | 
    900:
    VNRNDAQSAY | FIGLLISLDK | KFAWMDGSKV | DYVSWATGEP | NFANEDENCV | 
    950:
    TMYSNSGFWN | DINCGYPNAF | ICQRHNSSIN | ATTVMPTMPS | VPSGCKEGWN | 
    1000:
    FYSNKCFKIF | GFMEEERKNW | QEARKACIGF | GGNLVSIQNE | KEQAFLTYHM | 
    1050:
    KDSTFSAWTG | LNDVNSEHTF | LWTDGRGVHY | TNWGKGYPGG | RRSSLSYEDA | 
    1100:
    DCVVIIGGAS | NEAGKWMDDT | CDSKRGYICQ | TRSDPSLTNP | PATIQTDGFV | 
    1150:
    KYGKSSYSLM | RQKFQWHEAE | TYCKLHNSLI | ASILDPYSNA | FAWLQMETSN | 
    1200:
    ERVWIALNSN | LTDNQYTWTD | KWRVRYTNWA | ADEPKLKSAC | VYLDLDGYWK | 
    1250:
    TAHCNESFYF | LCKRSDEIPA | TEPPQLPGRC | PESDHTAWIP | FHGHCYYIES | 
    1300:
    SYTRNWGQAS | LECLRMGSSL | VSIESAAESS | FLSYRVEPLK | SKTNFWIGLF | 
    1350:
    RNVEGTWLWI | NNSPVSFVNW | NTGDPSGERN | DCVALHASSG | FWSNIHCSSY | 
    1400:
    KGYICKRPKI | IDAKPTHELL | TTKADTRKMD | PSKPSSNVAG | VVIIVILLIL | 
    1450:
    TGAGLAAYFF | YKKRRVHLPQ | EGAFENTLYF | NSQSSPGTSD | MKDLVGNIEQ | 
    1456:
    NEHSVI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    MIM:
    UniGene:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human MMR
    Cat.:
    E1542h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human MMR
    Cat.:
    E1542m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MMR
    Cat.:
    U1542h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MMR
    Cat.:
    U1542m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MMR
    Cat.:
    P1542Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MMR
    Cat.:
    P1542Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MMR
    Monoclonal Antibody for Human MMR
    Protein for Human MMR
    Protein for Human MMR

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains."
      Taylor M.E. , Conary J.T. , Lennartz M.R. , Stahl P.D. , Drickamer K.
      J. Biol. Chem.265:12156-12162(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    2. 2.
      "Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells."
      Ezekowitz R.A. , Sastry K. , Bailly P. , Warner A.
      J. Exp. Med.172:1785-1794(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Organization of the gene encoding the human macrophage mannose receptor (MRC1)."
      Kim S.J. , Ruiz N. , Bezouska K. , Drickamer K.
      Genomics14:721-727(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANTS SER-396; ALA-399 AND PHE-407
    7. 7.
      "Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor."
      Taylor M.E. , Bezouska K. , Drickamer K.
      J. Biol. Chem.267:1719-1726(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STUDIES ON THE BINDING OF INDIVIDUAL LECTIN DOMAINS
    8. 8.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1205
      tissue: Milk.
    9. 9.
      "Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor."
      Feinberg H. , Park-Snyder S. , Kolatkar A.R. , Heise C.T. , Taylor M.E. , Weis W.I.
      J. Biol. Chem.275:21539-21548(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 642-788
    10. 10.
      "Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility."
      Alter A. , de Leseleuc L. , Van Thuc N. , Thai V.H. , Huong N.T. , Ba N.N. , Cardoso C.C. , Grant A.V. , Abel L. , Moraes M.O. , Alcais A. , Schurr E.
      Hum. Genet.127:337-348(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;POSSIBLE ASSOCIATION OF VARIANT SER-396 WITH RESISTANCE TO LEPROSY;VARIANTS ILE-167; ALA-399 AND PHE-407;SUBCELLULAR LOCATION
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