ABCC1 ELISA Kit for Human(Homo sapiens) | EIAab.comABCC1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ABCC1(Gene name) > Human

ABCC1 (Gene name),

Multidrug resistance-associated protein 1 (Protein name ), MRP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

ABCC1(MRP;MRP1);

Protein name:

Multidrug resistance-associated protein 1;

Alternative:

Leukotriene C(4) transporter(LTC4 transporter);ATP-binding cassette sub-family C member 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1531

Sequence:

50:

100:

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650:

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1150:

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1250:

1300:

1350:

1400:

1450:

1500:

1531:

DKGEIQEYGA | PSDLLQQRGL | FYSMAKDAGL | V

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P33527

KEGG:

hsa:4363

UniGene:

Hs.391464

Pfam:

PF00664

MIM:

158343

SMR:

P33527

Uniprot:

P33527

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068h

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068r

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068c

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068m

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068d

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ELISA Kit for Human Multidrug resistance-associated protein 1

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E1068b

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96T

CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068d

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96T

CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068m

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96T

CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068c

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96T

CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068b

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96T

CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068r

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CLIA Kit for Human Multidrug resistance-associated protein 1

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U1068h

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Polyclonal Antibody for Human Multidrug resistance-associated protein 1

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P1068Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Multidrug resistance-associated protein 1

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P1068Rb-m

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Polyclonal Antibody for Human Multidrug resistance-associated protein 1

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P1068Rb-r

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Monoclonal Antibody for Human Multidrug resistance-associated protein 1

Protein for Human Multidrug resistance-associated protein 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line."
Cole S.P.C. , Bhardwaj G. , Gerlach J.H. , Mackie J.E. , Grant C.E. , Almquist K.C. , Stewart A.J. , Kurz E.U. , Duncan A.M.V. , Deeley R.G.
Science258:1650-1654(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-117
2.

"Multidrug resistance-associated protein: sequence correction."
Cole S.P.C. , Deeley R.G.
Science260:879-879(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
Grant C.E. , Kurz E.U. , Cole S.P.C. , Deeley R.G.
Genomics45:368-378(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANT THR-117
4.

NIEHS SNPs program
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-671; GLN-723; THR-861; SER-1047 AND ILE-1146
5.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-1531 (ISOFORM 9)
tissue: Brain.
7.

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Loftus B.J. , Kim U.-J. , Sneddon V.P. , Kalush F. , Brandon R. , Fuhrmann J. , Mason T. , Crosby M.L. , Barnstead M. , Cronin L. , Mays A.D. , Cao Y. , Xu R.X. , Kang H.-L. , Mitchell S. , Eichler E.E. , Harris P.C. , Venter J.C. , more...
Genomics60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 516-1531
8.

"Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus."
Hipfner D.R. , Almquist K.C. , Leslie E.M. , Gerlach J.H. , Grant C.E. , Deeley R.G. , Cole S.P.C.
J. Biol. Chem.272:23623-23630(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY;GLYCOSYLATION AT ASN-19; ASN-23 AND ASN-1006
9.

"Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence."
Kast C. , Gros P.
J. Biol. Chem.272:26479-26487(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
10.

"Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein."
Kast C. , Gros P.
Biochemistry37:2305-2313(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
11.

"Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1."
Sjoelinder M. , Tornhamre S. , Claesson H.-E. , Hydman J. , Lindgren J.A.
J. Lipid Res.40:439-446(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes."
Robbiani D.F. , Finch R.A. , Jaeger D. , Muller W.A. , Sartorelli A.C. , Randolph G.J.
Cell103:757-768(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation."
Cui L. , Hou Y.-X. , Riordan J.R. , Chang X.-B.
Arch. Biochem. Biophys.392:153-161(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-792; ASP-793; LYS-1333 AND 1454-ASP-GLU-1455
14.

"Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport."
Ito K. , Olsen S.L. , Qiu W. , Deeley R.G. , Cole S.P.C.
J. Biol. Chem.276:15616-15624(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TRP-1246
15.

"Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines."
Zhang D.-W. , Cole S.P.C. , Deeley R.G.
J. Biol. Chem.276:13231-13239(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-1089
16.

"Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter."
Situ D. , Haimeur A. , Conseil G. , Sparks K.E. , Zhang D.-W. , Deeley R.G. , Cole S.P.C.
J. Biol. Chem.279:38871-38880(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-1046; ASP-1084 AND ARG-1131
17.

"Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1."
Zhang D.-W. , Nunoya K. , Vasa M. , Gu H.-M. , Theis A. , Cole S.P.C. , Deeley R.G.
Biochemistry43:9413-9425(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLN-580; THR-581; SER-585; ASN-597; SER-604 AND SER-605
18.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1)."
Conseil G. , Deeley R.G. , Cole S.P.
J. Biol. Chem.281:43-50(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ARG-1138; LYS-1141 AND ARG-1142;SUBCELLULAR LOCATION
20.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
23.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-905 AND SER-930;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site."
Ramaen O. , Leulliot N. , Sizun C. , Ulryck N. , Pamlard O. , Lallemand J.-Y. , Tilbeurgh H. , Jacquet E.
J. Mol. Biol.359:940-949(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 642-871 IN COMPLEX WITH MG-ATP
27.

"Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum."
Le Saux O. , Urban Z. , Tschuch C. , Csiszar K. , Bacchelli B. , Quaglino D. , Pasquali-Ronchetti I. , Pope F.M. , Richards A. , Terry S. , Bercovitch L. , de Paepe A. , Boyd C.D.
Nat. Genet.25:223-227(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-633 AND VAL-671
28.

"Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter."
Ringpfeil F. , Lebwohl M.G. , Christiano A.M. , Uitto J.
Proc. Natl. Acad. Sci. U.S.A.97:6001-6006(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-671
29.

"Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution."
Conrad S. , Kauffmann H.-M. , Ito K. , Deeley R.G. , Cole S.P.C. , Schrenk D.
J. Hum. Genet.46:656-663(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-433;CHARACTERIZATION OF VARIANT VAL-671
30.

"Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum."
Perdu J. , Germain D.P.
Hum. Mutat.17:74-75(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-117 AND LEU-1512
31.

"Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
Ito S. , Ieiri I. , Tanabe M. , Suzuki A. , Higuchi S. , Otsubo K.
Pharmacogenetics11:175-184(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-43; ILE-73; GLN-723 AND GLN-1058
32.

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J. , Mardis E.R. , Ding L. , Fulton B. , McLellan M.D. , Chen K. , Dooling D. , Dunford-Shore B.H. , McGrath S. , Hickenbotham M. , Cook L. , Abbott R. , Larson D.E. , Koboldt D.C. , Pohl C. , Smith S. , Hawkins A. , Abbott S. , more...
Nature456:66-72(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-433

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