MC1R ELISA Kit for Human(Homo sapiens) | EIAab.comMC1R ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MC1R(Gene name) > Human

MC1R (Gene name),

Melanocyte-stimulating hormone receptor (Protein name ), MSHR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MC1R(MSHR);

Protein name:

Melanocyte-stimulating hormone receptor(MSH-R);

Alternative:

Melanocortin receptor 1(MC1-R);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production.

Function:

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

317

Sequence:

50:

100:

150:

200:

250:

300:

317:

HSQELRRTLK | EVLTCSW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.513829

MIM:

155555

Pfam:

PF00001

SMR:

Q01726

KEGG:

hsa:4157

String:

Q01726

Uniprot:

Q01726

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ELISA Kit for Human MSH-R

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E9983h

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ELISA Kit for Human MSH-R

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E9983p

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96T

ELISA Kit for Human MSH-R

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E9983m

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96T

ELISA Kit for Human MSH-R

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E9983c

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96T

ELISA Kit for Human MSH-R

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E9983d

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96T

ELISA Kit for Human MSH-R

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E9983b

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983m

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983d

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983c

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983h

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983p

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MSDS:

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96T

CLIA Kit for Human MSH-R

Cat.:

U9983b

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96T

Polyclonal Antibody for Human MSH-R

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P9983Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MSH-R

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P9983Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MSH-R

Monoclonal Antibody for Human MSH-R

Protein for Human MSH-R

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The cloning of a family of genes that encode the melanocortin receptors."
Mountjoy K.G. , Robbins L.S. , Mortrud M. , Cone R.D.
Science257:1248-1251(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Skin.
2.

"Molecular cloning of a novel melanocortin receptor."
Gantz I. , Konda Y. , Tashiro T. , Shimoto Y. , Miwa H. , Munzert G. , Watson S.J. , Delvalle J. , Yamada T.
J. Biol. Chem.268:8246-8250(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA."
Chhajlani V. , Wikberg J.E.S.
FEBS Lett.309:417-420(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

Chhajlani V. , Wikberg J.E.S.
FEBS Lett.390:238-238(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
5.

"High polymorphism at the human melanocortin 1 receptor locus."
Rana B.K. , Hewett-Emmett D. , Jin L. , Chang B.H. , Sambuughin N. , Lin M. , Watkins S. , Bamshad M. , Jorde L.B. , Ramsay M. , Jenkins T. , Li W.H.
Genetics151:1547-1557(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-67; GLU-84; MET-92; CYS-151 AND GLN-163
6.

"The Pro162 variant is a loss-of-function mutation of the human melanocortin 1 receptor gene."
Jimenez-Cervantes C. , Olivares C. , Gonzalez P. , Morandini R. , Ghanem G. , Garcia-Borron J.C.
J. Invest. Dermatol.117:156-158(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-162
7.

"The human melanocortin-1 receptor locus: analysis of transcription unit, locus polymorphism and haplotype evolution."
Smith A.G. , Box N.F. , Marks L.H. , Chen W. , Smit D.J. , Wyeth J.R. , Huttley G.A. , Easteal S. , Sturm R.A.
Gene281:81-94(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor."
Jimenez-Cervantes C. , Germer S. , Gonzalez P. , Sanchez J. , Sanchez C.O. , Garcia-Borron J.C.
FEBS Lett.508:44-48(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-40 AND MET-122
9.

"Identification of novel functional variants of the melanocortin 1 receptor gene originated from Asians."
Nakayama K. , Soemantri A. , Jin F. , Dashnyam B. , Ohtsuka R. , Duanchang P. , Isa M.N. , Settheetham-Ishida W. , Harihara S. , Ishida T.
Hum. Genet.119:322-330(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-67; THR-120; PHE-147 DEL; CYS-151; ILE-157; THR-159; GLN-163; GLY-166 AND MET-192;CHARACTERIZATION OF VARIANTS GLN-67; THR-120; PHE-147 DEL; CYS-151; ILE-157; THR-159; GLN-163; GLY-166 AND MET-192
10.

Pastorino L. , Cusano R. , Lantieri F. , Origone P. , Bruno W. , Barile M. , Gliori S. , Sturm R.A. , Bianchi Scarra' G.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
11.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
12.

SeattleSNPs variation discovery resource
Submitted (2002-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-60; MET-92; CYS-151; THR-155; LEU-156; TRP-160; GLN-163 AND LEU-196
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-155
tissue: Skin.
14.

"The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans."
Mogil J.S. , Wilson S.G. , Chesler E.J. , Rankin A.L. , Nemmani K.V. , Lariviere W.R. , Groce M.K. , Wallace M.R. , Kaplan L. , Staud R. , Ness T.J. , Glover T.L. , Stankova M. , Mayorov A. , Hruby V.J. , Grisel J.E. , Fillingim R.B.
Proc. Natl. Acad. Sci. U.S.A.100:4867-4872(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH FEMALE-SPECIFIC ANALGESIA FROM KAPPA-OPIOID RECEPTOR
15.

"Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas."
Perez-Oliva A.B. , Olivares C. , Jimenez-Cervantes C. , Garcia-Borron J.C.
J. Biol. Chem.284:31714-31725(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MGRN1;MUTAGENESIS OF LYS-65; LYS-226; LYS-238 AND LYS-310
16.

"Modeling of the three-dimensional structure of the human melanocortin 1 receptor, using an automated method and docking of a rigid cyclic melanocyte-stimulating hormone core peptide."
Prusis P. , Schioth H.B. , Muceniece R. , Herzyk P. , Afshar M. , Hubbard R.E. , Wikberg J.E.
J. Mol. Graph. Model.15:307-317(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
17.

"Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans."
Valverde P. , Healy F. , Jackson I. , Rees J.L. , Thody A.J.
Nat. Genet.11:328-330(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-294
18.

"The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma."
Valverde P. , Healy E. , Sikkink S. , Haldane F. , Thody A.J. , Carothers A. , Jackson I.J. , Rees J.L.
Hum. Mol. Genet.5:1663-1666(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLU-84
19.

"Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair."
Box N.F. , Wyeth J.R. , O'Gorman L.E. , Martin N.G. , Sturm R.A.
Hum. Mol. Genet.6:1891-1897(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-60; MET-92; CYS-151; TRP-160 AND HIS-294
20.

"Identification of common polymorphisms in the coding sequence of the human MSH receptor (MC1R) with possible biological effects."
Koppula S.V. , Robbins L.S. , Lu D. , Baack E. , White C.R. Jr. , Swanson N.A. , Cone R.D.
Hum. Mutat.9:30-36(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-84 AND MET-92
21.

"Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor."
Fraendberg P.-A. , Doufexis M. , Kapas S. , Chhajlani V.
Biochem. Biophys. Res. Commun.245:490-492(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-151
22.

"Melanocortin 1 receptor variants in an Irish population."
Smith R. , Healy E. , Siddiqui S. , Flanagan N. , Steijlen P.M. , Rosdahl I. , Jacques J.P. , Rogers S. , Turner R. , Jackson I.J. , Birch-MacHin M.A. , Rees J.L.
J. Invest. Dermatol.111:119-122(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-160
23.

"Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair."
Schioeth H.B. , Phillips S.R. , Rudzish R. , Birch-Machin M.A. , Wikberg J.E.S. , Rees J.L.
Biochem. Biophys. Res. Commun.260:488-491(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS LEU-60; HIS-142; CYS-151; TRP-160 AND HIS-294
24.

"Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function."
Sanchez Mas J. , Olivares Sanchez C. , Ghanem G. , Haycock J. , Lozano Teruel J.A. , Garcia-Borron J.C. , Jimenez-Cervantes C.
Eur. J. Biochem.269:6133-6141(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-93; HIS-142 AND CYS-151;CHARACTERIZATION OF VARIANTS ARG-93 AND CYS-151
25.

"MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population."
Fernandez L. , Milne R. , Bravo J. , Lopez J. , Aviles J. , Longo M. , Benitez J. , Lazaro P. , Ribas G.
Carcinogenesis28:1659-1664(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMM5 PHE-41 AND THR-128;VARIANTS LEU-60; THR-155; TRP-160; GLN-163; MET-192; SER-281 AND HIS-294
26.

"Genetic determinants of hair, eye and skin pigmentation in Europeans."
Sulem P. , Gudbjartsson D.F. , Stacey S.N. , Helgason A. , Rafnar T. , Magnusson K.P. , Manolescu A. , Karason A. , Palsson A. , Thorleifsson G. , Jakobsdottir M. , Steinberg S. , Palsson S. , Jonasson F. , Sigurgeirsson B. , Thorisdottir K. , Ragnarsson R. , Benediktsdottir K.R. , more...
Nat. Genet.39:1443-1452(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-151;ASSOCIATION WITH SHEP2
27.

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J. , Mardis E.R. , Ding L. , Fulton B. , McLellan M.D. , Chen K. , Dooling D. , Dunford-Shore B.H. , McGrath S. , Hickenbotham M. , Cook L. , Abbott R. , Larson D.E. , Koboldt D.C. , Pohl C. , Smith S. , Hawkins A. , Abbott S. , more...
Nature456:66-72(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-60 AND MET-92
28.

"Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients."
Perez Oliva A.B. , Fernendez L.P. , DeTorre C. , Herraiz C. , Martinez-Escribano J.A. , Benitez J. , Lozano Teruel J.A. , Garcia-Borron J.C. , Jimenez-Cervantes C. , Ribas G.
Hum. Mutat.30:811-822(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMM5 MET-38; ALA-51 AND ARG-289;CHARACTERIZATION OF VARIANTS CMM5 MET-38; PHE-41; ALA-51; THR-128 AND ARG-289;CHARACTERIZATION OF VARIANT SER-281

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