Protein name:
Mdm2-binding protein (hMTBP) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MDM2.
Function:
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Subcellular Location:
N/A
Protein Attributes:
50:
MDRYLLLVIW | GEGKFPSAAS | REAEHGPEVS | SGEGTENQPD | FTAANVYHLL |
100:
KRSISASINP | EDSTFPACSV | GGIPGSKKWF | FAVQAIYGFY | QFCSSDWQEI |
150:
HFDTEKDKIE | DVLQTNIEEC | LGAVECFEEE | DSNSRESLSL | ADLYEEAAEN |
200:
LHQLSDKLPA | PGRAMVDIIL | LLSDKDPPKL | KDYLPTVGAL | KHLREWYSAK |
250:
ITIAGNHCEI | NCQKIAEYLS | ANVVSLEDLR | NVIDSKELWR | GKIQIWERKF |
300:
GFEISFPEFC | LKGVTLKNFS | TSNLNTDFLA | KKIIPSKDKN | ILPKVFHYYG |
350:
PALEFVQMIK | LSDLPSCYMS | DIEFELGLTN | STKQNSVLLL | EQISSLCSKV |
400:
GALFVLPCTI | SNILIPPPNQ | LSSRKWKEYI | AKKPKTISVP | DVEVKGECSS |
450:
YYLLLQGNGN | RRCKATLIHS | ANQINGSFAL | NLIHGKMKTK | TEEAKLSFPF |
500:
DLLSLPHFSG | EQIVQREKQL | ANVQVLALEE | CLKRRKLAKQ | PETVSVAELK |
550:
SLLVLTRKHF | LDYFDAVIPK | MILRKMDKIK | TFNILNDFSP | VEPNSSSLME |
600:
TNPLEWPERH | VLQNLETFEK | TKQKMRTGSL | PHSSEQLLGH | KEGPRDSITL |
650:
LDAKELLKYF | TSDGLPIGDL | QPLPIQKGEK | TFVLTPELSP | GKLQVLPFEK |
700:
ASVCHYHGIE | YCLDDRKALE | RDGGFSELQS | RLIRYETQTT | CTRESFPVPT |
750:
VLSPLPSPVV | SSDPGSVPDG | EVLQNELRTE | VSRLKRRSKD | LNCLYPRKRL |
800:
VKSESSESLL | SQTTGNSNHY | HHHVTSRKPQ | TERSLPVTCP | LVPIPSCETP |
850:
KLATKTSSGQ | KSMHESKTSR | QIKESRSQKH | TRILKEVVTE | TLKKHSITET |
900:
HECFTACSQR | LFEISKFYLK | DLKTSRGLFE | EMKKTANNNA | VQVIDWVLEK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human hMTBP
ELISA Kit for Human hMTBP
Polyclonal Antibody for Human hMTBP
Polyclonal Antibody for Human hMTBP
Monoclonal Antibody for Human hMTBP
Monoclonal Antibody for Human hMTBP
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-141 (ISOFORM 1)
tissue :
Embryo .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Prostate .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MDM2
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-707;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .