MCAM ELISA Kit for Human(Homo sapiens) | EIAab.comMCAM ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MCAM(Gene name) > Human

MCAM (Gene name),

Cell surface glycoprotein MUC18 (Protein name ), MUC18_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MCAM(MUC18);

Protein name:

Cell surface glycoprotein MUC18;

Alternative:

Melanoma cell adhesion molecule;Cell surface glycoprotein P1H12;Melanoma-associated antigen MUC18;Melanoma-associated antigen A32;S-endo 1 endothelial-associated antigen;

CD:

CD146;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

646

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

646:

PPSRKSELVV | EVKSDKLPEE | MGLLQGSSGD | KRAPGDQGEK | YIDLRH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:4162

MIM:

155735

Pfam:

PF08205

SMR:

P43121

String:

P43121

STRING:

9606.ENSP00000264036

UniGene:

Hs.599039

Uniprot:

P43121

FOR

ELISA Kit for Human Cell surface glycoprotein MUC18

Cat.:

E1670h

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Manual:

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Packing:

96T

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ELISA Kit for Human Cell surface glycoprotein MUC18

Cat.:

E1670m

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MSDS:

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Packing:

96T

ELISA Kit for Human Cell surface glycoprotein MUC18

Cat.:

E1670r

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Packing:

96T

CLIA Kit for Human Cell surface glycoprotein MUC18

Cat.:

U1670m

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MSDS:

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Packing:

96T

CLIA Kit for Human Cell surface glycoprotein MUC18

Cat.:

U1670r

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MSDS:

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Packing:

96T

CLIA Kit for Human Cell surface glycoprotein MUC18

Cat.:

U1670h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Cell surface glycoprotein MUC18

Cat.:

P1670Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Cell surface glycoprotein MUC18

Cat.:

P1670Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Cell surface glycoprotein MUC18

Cat.:

P1670Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cell surface glycoprotein MUC18

Protein for Human Cell surface glycoprotein MUC18

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily."
Lehmann J.M. , Riethmueller G. , Johnson J.P.
Proc. Natl. Acad. Sci. U.S.A.86:9891-9895(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Melanoma.
2.

"Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains."
Sers C. , Kirsch K. , Rothbaecher U. , Riethmueller G. , Johnson J.P.
Proc. Natl. Acad. Sci. U.S.A.90:8514-8518(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);SEQUENCE REVISION
tissue: Melanoma.
3.

"Identification and functional assessment of endothelial P1H12."
Solovey A.N. , Gui L. , Chang L. , Enenstein J. , Browne P.V. , Hebbel R.P.
J. Lab. Clin. Med.138:322-331(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Trachea.
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-89
tissue: Aortic endothelium.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: PNS.
7.

"Isolation and functional characterization of the A32 melanoma-associated antigen."
Shih I.-M. , Eleder D.E. , Speicher D. , Johnson J.P. , Herlyn M.
Cancer Res.54:2514-2520(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-44; 98-112; 135-153; 240-260; 379-389 AND 460-478
8.

"Identification of the S-endo 1 endothelial-associated antigen."
Bardin N. , Frances V. , Lesaule G. , Horschowski N. , George F. , Sampol J.
Biochem. Biophys. Res. Commun.218:210-216(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-40; 98-112 AND 236-260
9.

"The progression associated antigen MUC18: a unique member of the immunoglobulin supergene family."
Johnson J.P. , Rothbacher U. , Sers C.
Melanoma Res.3:337-340(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Outside-in signaling pathway linked to CD146 engagement in human endothelial cells."
Anfosso F. , Bardin N. , Vivier E. , Sabatier F. , Sampol J. , Dignat-George F.
J. Biol. Chem.276:1564-1569(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-467
tissue: Liver.
13.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614 AND SER-628;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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