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Index > Protein center > MUC20(Gene name) > Human
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  • MUC20 (Gene name),
  • Mucin-20 (Protein name ),  MUC20_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    MUC20(UNQ2782/PRO7170;KIAA1359);
    Protein name:
    Mucin-20(MUC-20);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MET; oligomerization increases affinity for MET.
    Function:
    May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
    Subcellular Location:
    Secreted Apical cell membrane Basolateral cell membrane Cell projection microvillus membrane
    Protein Attributes:
    Sequence length:
    709
    Sequence:
    50:
    MGCLWGLALP | LFFFCWEVGV | SGSSAGPSTR | RADTAMTTDD | TEVPAMTLAP | 
    100:
    GHAALETQTL | SAETSSRAST | PAGPIPEAET | RGAKRISPAR | ETRSFTKTSP | 
    150:
    NFMVLIATSV | ETSAASGSPE | GAGMTTVQTI | TGSDPREAIF | DTLCTDDSSE | 
    200:
    EAKTLTMDIL | TLAHTSTEAK | GLSSESSASS | DSPHPVITPS | RASESSASSD | 
    250:
    GPHPVITPSR | ASESSASSDG | PHPVITPSRA | SESSASSDGP | HPVITPSRAS | 
    300:
    ESSASSDGPH | PVITPSRASE | SSASSDGPHP | VITPSRASES | SASSDGPHPV | 
    350:
    ITPSRASESS | ASSDGPHPVI | TPSRASESSA | SSDGPHPVIT | PSRASESSAS | 
    400:
    SDGLHPVITP | SRASESSASS | DGPHPVITPS | RASESSASSD | GPHPVITPSW | 
    450:
    SPGSDVTLLA | EALVTVTNIE | VINCSITEIE | TTTSSIPGAS | DTDLIPTEGV | 
    500:
    KASSTSDPPA | LPDSTEAKPH | ITEVTASAET | LSTAGTTESA | APDATVGTPL | 
    550:
    PTNSATEREV | TAPGATTLSG | ALVTVSRNPL | EETSALSVET | PSYVKVSGAA | 
    600:
    PVSIEAGSAV | GKTTSFAGSS | ASSYSPSEAA | LKNFTPSETP | TMDIATKGPF | 
    650:
    PTSRDPLPSV | PPTTTNSSRG | TNSTLAKITT | SAKTTMKPPT | ATPTTARTRP | 
    700:
    TTDVSAGENG | GFLLLRLSVA | SPEDLTDPRV | AERLMQQLHR | ELHAHAPHFQ | 
    709:
    VSLLRVRRG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MUC-20
    Cat.:
    E1087h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human MUC-20
    Cat.:
    E1087m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MUC-20
    Cat.:
    U1087h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human MUC-20
    Cat.:
    U1087m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MUC-20
    Cat.:
    P1087Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MUC-20
    Cat.:
    P1087Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MUC-20
    Monoclonal Antibody for Human MUC-20
    Protein for Human MUC-20
    Protein for Human MUC-20

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney."
      Higuchi T. , Orita T. , Nakanishi S. , Katsuya K. , Watanabe H. , Yamasaki Y. , Waga I. , Nanayama T. , Yamamoto Y. , Munger W. , Sun H.-W. , Falk R.J. , Jennette J.C. , Alcorta D.A. , Li H. , Yamamoto T. , Saito Y. , Nakamura M.
      J. Biol. Chem.279:1968-1979(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANTS 184-HIS--LEU-354 DEL; 241-HIS--LEU-354 DEL AND ILE-442;POLYMORPHISM;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Kidney.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS 184-HIS--LEU-354 DEL AND ILE-442
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS 184-HIS--LEU-354 DEL; ILE-442 AND 483-THR--THR-533 DEL
      tissue: Embryo.
      tissue: Placenta.
    4. 4.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS 184-HIS--LEU-354 DEL; 203-HIS--LEU-354; DEL ILE-442 AND LEU-590
      tissue: Brain.
      tissue: Colon.
    6. 6.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-638 (ISOFORM 1);VARIANT 241-HIS--LEU-354 DEL
      tissue: Brain.
    7. 7.
      "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
      Higuchi T. , Orita T. , Katsuya K. , Yamasaki Y. , Akiyama K. , Li H. , Yamamoto T. , Saito Y. , Nakamura M.
      Mol. Cell. Biol.24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MET
    8. 8.
      "Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy."
      Li G. , Zhang H. , Lv J. , Hou P. , Wang H.
      Am. J. Nephrol.26:43-49(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TANDEM REPEATS POLYMORPHISM
    9. 9.
      "Mucin gene expression in human male urogenital tract epithelia."
      Russo C.L. , Spurr-Michaud S. , Tisdale A. , Pudney J. , Anderson D. , Gipson I.K.
      Hum. Reprod.21:2783-2793(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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