MUC2 ELISA Kit for Human(Homo sapiens) | EIAab.comMUC2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MUC2(Gene name) > Human

MUC2 (Gene name),

Mucin-2 (Protein name ), MUC2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MUC2(SMUC);

Protein name:

Mucin-2(MUC-2);

Alternative:

Intestinal mucin-2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.

Function:

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Subcellular Location:

Secreted In the intestine, secreted into the inner and outer mucus layers.

Protein Attributes:

Sequence length:

5179

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SCQCQDTVCG | LPTGTSRRAR | RSPRHLGSG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08742

MIM:

158370

KEGG:

hsa:4583

UniGene:

Hs.315

SMR:

Q02817

String:

Q02817

STRING:

9606.ENSP00000415183

Uniprot:

Q02817

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ELISA Kit for Human MUC-2

Cat.:

E0705m

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Packing:

96T

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ELISA Kit for Human MUC-2

Cat.:

E0705h

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96T

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ELISA Kit for Human MUC-2

Cat.:

E0705c

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96T

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ELISA Kit for Human MUC-2

Cat.:

E0705r

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MSDS:

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Packing:

96T

CLIA Kit for Human MUC-2

Cat.:

U0705c

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MSDS:

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Packing:

96T

CLIA Kit for Human MUC-2

Cat.:

U0705m

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MSDS:

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Packing:

96T

CLIA Kit for Human MUC-2

Cat.:

U0705h

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MSDS:

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Packing:

96T

CLIA Kit for Human MUC-2

Cat.:

U0705r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human MUC-2

Cat.:

P0705Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MUC-2

Cat.:

P0705Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MUC-2

Cat.:

P0705Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MUC-2

Protein for Human MUC-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."
Gum J.R. Jr. , Hicks J.W. , Toribara N.W. , Siddiki B. , Kim Y.S.
J. Biol. Chem.269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Intestine.
2.

"The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."
Gum J.R. Jr. , Hicks J.W. , Toribara N.W. , Rothe E.-M. , Lagace R.E. , Kim Y.S.
J. Biol. Chem.267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 626-1895 AND 4196-5179
tissue: Colon.
3.

"MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."
Toribara N.W. , Gum J.R. Jr. , Culhane P.J. , Lagace R.E. , Hicks J.W. , Petersen G.M. , Kim Y.S.
J. Clin. Invest.88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1343-1895 AND 4176-4195
4.

"Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."
Gum J.R. Jr. , Byrd J.C. , Hicks J.W. , Toribara N.W. , Lamport D.T.A. , Kim Y.S.
J. Biol. Chem.264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4075-4352
5.

"Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."
Xu G. , Huan L. , Khatri I. , Sajjan U.S. , McCool D. , Wang D. , Jones C. , Forstner G. , Forstner J.
Biochem. Biophys. Res. Commun.183:821-828(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4487-4627
6.

"In vivo glycosylation of mucin tandem repeats."
Silverman H.S. , Parry S. , Sutton-Smith M. , Burdick M.D. , McDermott K. , Reid C.J. , Batra S.K. , Morris H.R. , Hollingsworth M.A. , Dell A. , Harris A.
Glycobiology11:459-471(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES
7.

"The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."
Godl K. , Johansson M.E.V. , Lidell M.E. , Moergelin M. , Karlsson H. , Olson F.J. , Gum J.R. Jr. , Kim Y.S. , Hansson G.C.
J. Biol. Chem.277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
8.

"An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."
Lidell M.E. , Johansson M.E.V. , Hansson G.C.
J. Biol. Chem.278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOCATALYTIC CLEAVAGE
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
Park S.-W. , Zhen G. , Verhaeghe C. , Nakagami Y. , Nguyenvu L.T. , Barczak A.J. , Killeen N. , Erle D.J.
Proc. Natl. Acad. Sci. U.S.A.106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGR2
11.

"Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
Johansson M.E.V. , Thomsson K.A. , Hansson G.C.
J. Proteome Res.8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH FCGBP

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