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Index > Protein center > MUC3A(Gene name) > Human
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  • MUC3A (Gene name),
  • Mucin-3A (Protein name ),  MUC3A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MUC3A(MUC3);
    Protein name:
    Mucin-3A(MUC-3A);
    Alternative:
    Intestinal mucin-3A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
    Subcellular Location:
    Isoform 5 Secreted
    Protein Attributes:
    Sequence length:
    2541
    Sequence:
    50:
    MQLLGLLGLL | WMLKASPWAT | GTLSTATSIS | QVPFPRAEAA | SAVLSNSPHS | 
    100:
    RDLAGWPLGV | PQLASPAPGH | RENAPMTLTT | SPHDTLISET | LLNSPVSSNT | 
    150:
    STTPTSKFAF | KVETTPPTVL | VYSATTECVY | PTSFIITISH | PTSICVTTTQ | 
    200:
    VAFTSSYTST | PVTQKPVTTV | TSTYSMTTTE | KGTSAMTSSP | STTTARETPI | 
    250:
    VTVTPSSVSA | TDTTFHTTIS | STTRTTERTP | LPTGSIHTTT | SPTPVFTTLK | 
    300:
    TAVTSTSPIT | SSITSTNTVT | SMTTTASQPT | ATNTLSSPTR | TILSSTPVLS | 
    350:
    TETITSGITN | TTPLSTLVTT | LPTTISRSTP | TSETTYPTSP | XXXXXXXXXX | 
    400:
    AMTSPPPVSS | SITPTNTMTS | MRTTTYWPTA | TNTLSPLTSS | ILSSTPVPST | 
    450:
    EMITSHTTNT | TPLSTLVTTL | LTTITRSTPT | SETTYPTSPT | SIVSDSTTEI | 
    500:
    TYSTSITGTL | STATTLPPTS | SSLPTTETAT | MTPTTTLITT | TPNTTSHSTP | 
    550:
    SFTSSTIYST | VSTSTTAISS | ASPTSGTMVT | STTMTPSSLS | TDTPSTTPTT | 
    600:
    ITYPSVGSTG | FLTTATDLTS | TFTVSSSSAM | SKSVIPSSPS | IQNTETSSLV | 
    650:
    SMTSATTPSL | RPTITSTDST | LTSSLLTTFP | STYSFSSSMS | ASSAGTTHTE | 
    700:
    TISSLPASTN | TIHTTAESAL | APTTTTSFTT | SPTMEPPSTT | VATTGTGQTT | 
    750:
    FPSSTATFLE | TTTLTPTTDF | STESLTTAMT | STPPITSSIT | PTDTMTSMRT | 
    800:
    TTSWPTATNT | LSPLTSSILS | STPVPSTEVT | TSHTTNTNPV | STLVTTLPIT | 
    850:
    ITRSTLTSET | AYPSSPTSTV | TESTTEITYP | TTMTETSSTA | TSLPPTSSLV | 
    900:
    STAETAKTPT | TNLXXXXXXX | XXXFTSSTSL | LHSQHTTXLP | SPSVPTTLGT | 
    950:
    MVTSTSXIPS | SLSTDIPTSQ | PTTITPSSVG | ITGSLPMMTD | LTSVYTVSSM | 
    1000:
    SARPTSVIPS | SPTVQNTETS | IFVSMMSATT | PSGGSTFTST | ENTPTRSLLT | 
    1050:
    SFPVTHSFSS | SMSASSVGTT | HTQSISSPPA | ITSTLHTTAE | STPSPTTTMS | 
    1100:
    FTTFTKMETP | SSTVATTGTG | QTTFTSSTAT | SPKTTTLTPT | SDISTGSFKT | 
    1150:
    AVSSTPPITS | SITSTYTVTS | MTTTTPLGPT | ATNTLPSFTS | SVSSSTPVPS | 
    1200:
    TEAITSGTTN | TTPLSTLVTT | FSNSDTSSTP | TSETTYPTSL | TSALTDSTTR | 
    1250:
    TTYSTNMTGT | LSTVTSLRPT | SSSLLTTVTA | TVPTTNLVTT | TTKITSHSTP | 
    1300:
    SFTSSIATTE | TPSHSTPRFT | SSITTTETPS | HSTPRFTSSI | TNTKTTSHSS | 
    1350:
    PSFTSSITTT | DSIVXXXXXX | XXXXITITET | TSHSTPSYTT | SITTTETPSH | 
    1400:
    STPSYTTSIT | TTETPSHSTP | SFTSSITTTE | TTSHSTPSFT | SSIRTTETTS | 
    1450:
    YSTPSFTSSN | TITETTSHST | PSYITSITTT | ETPSSSTPSF | SSSITTTEIS | 
    1500:
    SHSTPSFSSS | TIYSTVTSHS | TPRFTSSITT | TETPSHSTPR | FTSSFTNTKT | 
    1550:
    TSHRSPSFTS | LITTTETTSH | STPSFTSSIT | TTETTSHSAR | SFTSSITTTE | 
    1600:
    TTSHNTRSFT | SSITTTETNS | HSTTSFTSSI | TTTETTSHST | PSFSSSITTT | 
    1650:
    ETPLHSTPGL | TSWVTTTKTT | SHITPGLTSS | ITTTETTSHS | TPGFTSSITT | 
    1700:
    TETTSESTPS | LSSSTIYSTV | STSTTAITSH | FTTSETAVTP | TPVTPSSLST | 
    1750:
    DIPTTSLRTL | TPSSVGTSTS | LTTTTDFPSI | PTDISTLPTR | THIISSSPSI | 
    1800:
    QSTETSSLVG | TTSPTMSTVR | MTLRITENTP | ISSFSTSIVV | IPETPTQTPP | 
    1850:
    VLTSATGTQT | SPAPTTVTFG | STDSSTSTLH | TLTPSTALST | IVSTSQVPIP | 
    1900:
    STHSSTLQTT | PSTPSLQTSL | TSTSEFTTES | FTRGSTSTNA | ILTSFSTIIW | 
    1950:
    SSTPTIIMSS | SPSSASITPV | FSTTIHSVPS | SPYIFSTENV | GSASITGFPS | 
    2000:
    LSSSATTSTS | STSSSLTTAL | TEITPFSYIS | LPSTTPCPGT | ITITIVPASP | 
    2050:
    TDPCVEMDPS | TEATSPPTTP | LTVFPFTTEM | VTCPTSISIQ | TTLTTYMDTS | 
    2100:
    SMMPESESSI | SPNASSSTGT | GTVPTNTVFT | STRLPTSETW | LSNSSVIPLP | 
    2150:
    LPGVSTIPLT | MKPSSSLPTI | LRTSSKSTHP | SPPTTRTSET | PVATTQTPTT | 
    2200:
    LTSRRTTRIT | SQMTTQSTLT | TTAGTCDNGG | TWEQGQCACL | PGFSGDRCQL | 
    2250:
    QTRCQNGGQW | DGLKCQCPST | FYGSSCEFAV | EQVDLDVVET | EVGMEVSVDQ | 
    2300:
    QFSPDLNDNT | SQAYRDFNKT | FWNQMQKIFA | DMQGFTFKGV | EILSLRNGSI | 
    2350:
    VVDYLVLLEM | PFSPQLESEY | EQVKTTLKEG | LQNASQDANS | CQDSQTLCFK | 
    2400:
    PDSIKVNNNS | KTELTPEAIC | RRAAPTGYEE | FYFPLVEATR | LRCVTKCTSG | 
    2450:
    VDNAIDCHQG | QCVLETSGPA | CRCYSTDTHW | FSGPRCEVAV | HWRALVGGLT | 
    2500:
    AGAALLVLLL | LALGVRAVRS | GWWGGQRRGR | SWDQDRKWFE | TWDEEVVGTF | 
    2541:
    SNWGFEDDGT | DKDTNFHVAL | ENVDTTMKVH | IKRPEMTSSS | V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MUC-3A
    Cat.:
    E1031h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human MUC-3A
    Cat.:
    U1031h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human MUC-3A
    Cat.:
    P1031Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MUC-3A
    Protein for Human MUC-3A

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus."
      Gum J.R. Jr. , Hicks J.W. , Crawley S.C. , Dahl C.M. , Yang S.C. , Roberton A.M. , Kim Y.S.
      J. Biol. Chem.278:49600-49609(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1)
    3. 3.
      "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region."
      Gum J.R. Jr. , Ho J.J.L. , Pratt W.S. , Hicks J.W. , Hill A.S. , Vinall L.E. , Roberton A.M. , Swallow D.M. , Kim Y.S.
      J. Biol. Chem.272:26678-26686(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 351-863 AND 874-1314 (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1325-2284 (ISOFORM 2)
    4. 4.
      "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin."
      Crawley S.C. , Gum J.R. Jr. , Hicks J.W. , Pratt W.S. , Aubert J.-P. , Swallow D.M. , Kim Y.S.
      Biochem. Biophys. Res. Commun.263:728-736(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-2541 (ISOFORM 1);ALTERNATIVE SPLICING (ISOFORMS 2; 3 AND 4);VARIANTS VAL-2338; ASN-2517 AND TYR-2517
      tissue: Intestine.
    5. 5.
      "Molecular cloning of cDNAs derived from a novel human intestinal mucin gene."
      Gum J.R. Jr. , Hicks J.W. , Swallow D.M. , Lagace R.L. , Byrd J.C. , Lamport D.T.A. , Siddiki B. , Kim Y.S.
      Biochem. Biophys. Res. Commun.171:407-415(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1238-1587
      tissue: Small intestine.
    6. 6.
      "Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B."
      Pratt W.S. , Crawley S. , Hicks J. , Ho J. , Nash M. , Kim Y.S. , Gum J.R. , Swallow D.M.
      Biochem. Biophys. Res. Commun.275:916-923(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1642-2541 (ISOFORM 1);VARIANTS VAL-2338; ASN-2517 AND TYR-2517
    7. 7.
      "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease."
      Kyo K. , Muto T. , Nagawa H. , Lathrop G.M. , Nakamura Y.
      J. Hum. Genet.46:5-20(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1665-2541 (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS VAL-2338 AND TYR-2517
    8. 8.
      "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced."
      Williams S.J. , Munster D.J. , Quin R.J. , Gotley D.C. , McGuckin M.A.
      Biochem. Biophys. Res. Commun.261:83-89(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2176-2541 (ISOFORMS 1; 2 AND 5);FUNCTION;VARIANTS VAL-2338 AND TYR-2517
      tissue: Colon mucosa.
      tissue: Small intestine.
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