Protein name:
Muscle, skeletal receptor tyrosine-protein kinase ;
Alternative:
Muscle-specific tyrosine-protein kinase receptor (MuSK;Muscle-specific kinase receptor) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Monomer. Homodimer (Probable). Interacts with DOK7. Interaction with DOK7 promotes activation by tyrosine phosphorylation. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with RNF31.
Function:
Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MRELVNIPLV | HILTLVAFSG | TEKLPKAPVI | TTPLETVDAL | VEEVATFMCA |
100:
VESYPQPEIS | WTRNKILIKL | FDTRYSIREN | GQLLTILSVE | DSDDGIYCCT |
150:
ANNGVGGAVE | SCGALQVKMK | PKITRPPINV | KIIEGLKAVL | PCTTMGNPKP |
200:
SVSWIKGDSP | LRENSRIAVL | ESGSLRIHNV | QKEDAGQYRC | VAKNSLGTAY |
250:
SKVVKLEVEV | FARILRAPES | HNVTFGSFVT | LHCTATGIPV | PTITWIENGN |
300:
AVSSGSIQES | VKDRVIDSRL | QLFITKPGLY | TCIATNKHGE | KFSTAKAAAT |
350:
ISIAEWSKPQ | KDNKGYCAQY | RGEVCNAVLA | KDALVFLNTS | YADPEEAQEL |
400:
LVHTAWNELK | VVSPVCRPAA | EALLCNHIFQ | ECSPGVVPTP | IPICREYCLA |
450:
VKELFCAKEW | LVMEEKTHRG | LYRSEMHLLS | VPECSKLPSM | HWDPTACARL |
500:
PHLDYNKENL | KTFPPMTSSK | PSVDIPNLPS | SSSSSFSVSP | TYSMTVIISI |
550:
MSSFAIFVLL | TITTLYCCRR | RKQWKNKKRE | SAAVTLTTLP | SELLLDRLHP |
600:
NPMYQRMPLL | LNPKLLSLEY | PRNNIEYVRD | IGEGAFGRVF | QARAPGLLPY |
650:
EPFTMVAVKM | LKEEASADMQ | ADFQREAALM | AEFDNPNIVK | LLGVCAVGKP |
700:
MCLLFEYMAY | GDLNEFLRSM | SPHTVCSLSH | SDLSMRAQVS | SPGPPPLSCA |
750:
EQLCIARQVA | AGMAYLSERK | FVHRDLATRN | CLVGENMVVK | IADFGLSRNI |
800:
YSADYYKANE | NDAIPIRWMP | PESIFYNRYT | TESDVWAYGV | VLWEIFSYGL |
850:
QPYYGMAHEE | VIYYVRDGNI | LSCPENCPVE | LYNLMRLCWS | KLPADRPSFT |
869:
SIHRILERMC | ERAEGTVSV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
Rat
ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury."
Valenzuela D.M.
,
Stitt T.N.
,
DiStefano P.S.
,
Rojas E.
,
Mattsson K.
,
Compton D.L.
,
Nunez L.
,
Park J.S.
,
Stark J.L.
,
Gies D.R.
,
Thomas S.
,
LeBeau M.M.
,
Fernald A.A.
,
Copeland N.G.
,
Jenkins N.A.
,
Burden S.J.
,
Glass D.J.
,
Yancopoulos G.D.
Neuron15:573-584(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING (ISOFORMS 2 AND 3)
2.
"DNA sequence and analysis of human chromosome 9."
Humphray S.J.
,
Oliver K.
,
Hunt A.R.
,
Plumb R.W.
,
Loveland J.E.
,
Howe K.L.
,
Andrews T.D.
,
Searle S.
,
Hunt S.E.
,
Scott C.E.
,
Jones M.C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Babbage S.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Chen Y.
,
Clarke G.
,
Clark S.Y.
,
Clee C.M.
,
Clegg S.
,
Collier R.E.
,
Corby N.
,
Crosier M.
,
Cummings A.T.
,
Davies J.
,
Dhami P.
,
Dunn M.
,
Dutta I.
,
Dyer L.W.
,
Earthrowl M.E.
,
Faulkner L.
,
Fleming C.J.
,
Frankish A.
,
Frankland J.A.
,
French L.
,
Fricker D.G.
,
Garner P.
,
Garnett J.
,
Ghori J.
,
Gilbert J.G.R.
,
Glison C.
,
Grafham D.V.
,
Gribble S.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Guy J.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Harrison E.S.I.
,
Hart E.A.
,
Heath P.D.
,
Henderson C.D.
,
Hopkins B.L.
,
Howard P.J.
,
Howden P.J.
,
Huckle E.
,
Johnson C.
,
Johnson D.
,
Joy A.A.
,
Kay M.
,
Keenan S.
,
Kershaw J.K.
,
Kimberley A.M.
,
King A.
,
Knights A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.
,
Lloyd D.M.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Milne S.
,
Nickerson T.
,
Nisbett J.
,
Nordsiek G.
,
Pearce A.V.
,
Peck A.I.
,
Porter K.M.
,
Pandian R.
,
Pelan S.
,
Phillimore B.
,
Povey S.
,
Ramsey Y.
,
Rand V.
,
Scharfe M.
,
Sehra H.K.
,
Shownkeen R.
,
Sims S.K.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Swarbreck D.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Thomas D.W.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Williams S.A.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Ashurst J.L.
,
Coulson A.
,
Blocker H.
,
Durbin R.M.
,
Sulston J.E.
,
Hubbard T.
,
Jackson M.J.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Dunham I.
more...
Nature429:369-374(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DOK7
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NEDDYLATION
6.
"MUSK, a new target for mutations causing congenital myasthenic syndrome."
Chevessier F.
,
Faraut B.
,
Ravel-Chapuis A.
,
Richard P.
,
Gaudon K.
,
Bauche S.
,
Prioleau C.
,
Herbst R.
,
Goillot E.
,
Ioos C.
,
Azulay J.-P.
,
Attarian S.
,
Leroy J.-P.
,
Fournier E.
,
Legay C.
,
Schaeffer L.
,
Koenig J.
,
Fardeau M.
,
Eymard B.
,
Pouget J.
,
Hantai D.
more...
Hum. Mol. Genet.13:3229-3240(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CMS-ACHRD MET-790
7.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLY-27; MET-100; GLU-107; GLY-159; SER-222; ILE-413; PHE-629; ALA-644; SER-664; LEU-696; ASP-782; SER-819; LEU-829 AND HIS-858
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CMS-ACHRD ILE-605 AND VAL-727;CHARACTERIZATION OF VARIANTS CMS-ACHRD ILE-605 AND VAL-727