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Index > Protein center > MUSK(Gene name) > Human
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  • MUSK (Gene name),
  • Muscle, skeletal receptor tyrosine-protein kinase (Protein name ),  MUSK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MUSK;
    Protein name:
    Muscle, skeletal receptor tyrosine-protein kinase;
    Alternative:
    Muscle-specific tyrosine-protein kinase receptor(MuSK;Muscle-specific kinase receptor);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer (Probable). Interacts with DOK7. Interaction with DOK7 promotes activation by tyrosine phosphorylation. Interacts with PDZRN3; this interaction is enhanced by agrin. Interacts with RNF31.
    Function:
    Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    869
    Sequence:
    50:
    MRELVNIPLV | HILTLVAFSG | TEKLPKAPVI | TTPLETVDAL | VEEVATFMCA | 
    100:
    VESYPQPEIS | WTRNKILIKL | FDTRYSIREN | GQLLTILSVE | DSDDGIYCCT | 
    150:
    ANNGVGGAVE | SCGALQVKMK | PKITRPPINV | KIIEGLKAVL | PCTTMGNPKP | 
    200:
    SVSWIKGDSP | LRENSRIAVL | ESGSLRIHNV | QKEDAGQYRC | VAKNSLGTAY | 
    250:
    SKVVKLEVEV | FARILRAPES | HNVTFGSFVT | LHCTATGIPV | PTITWIENGN | 
    300:
    AVSSGSIQES | VKDRVIDSRL | QLFITKPGLY | TCIATNKHGE | KFSTAKAAAT | 
    350:
    ISIAEWSKPQ | KDNKGYCAQY | RGEVCNAVLA | KDALVFLNTS | YADPEEAQEL | 
    400:
    LVHTAWNELK | VVSPVCRPAA | EALLCNHIFQ | ECSPGVVPTP | IPICREYCLA | 
    450:
    VKELFCAKEW | LVMEEKTHRG | LYRSEMHLLS | VPECSKLPSM | HWDPTACARL | 
    500:
    PHLDYNKENL | KTFPPMTSSK | PSVDIPNLPS | SSSSSFSVSP | TYSMTVIISI | 
    550:
    MSSFAIFVLL | TITTLYCCRR | RKQWKNKKRE | SAAVTLTTLP | SELLLDRLHP | 
    600:
    NPMYQRMPLL | LNPKLLSLEY | PRNNIEYVRD | IGEGAFGRVF | QARAPGLLPY | 
    650:
    EPFTMVAVKM | LKEEASADMQ | ADFQREAALM | AEFDNPNIVK | LLGVCAVGKP | 
    700:
    MCLLFEYMAY | GDLNEFLRSM | SPHTVCSLSH | SDLSMRAQVS | SPGPPPLSCA | 
    750:
    EQLCIARQVA | AGMAYLSERK | FVHRDLATRN | CLVGENMVVK | IADFGLSRNI | 
    800:
    YSADYYKANE | NDAIPIRWMP | PESIFYNRYT | TESDVWAYGV | VLWEIFSYGL | 
    850:
    QPYYGMAHEE | VIYYVRDGNI | LSCPENCPVE | LYNLMRLCWS | KLPADRPSFT | 
    869:
    SIHRILERMC | ERAEGTVSV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    String:
    SMR:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
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    E0992h
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    ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
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    E0992m
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    ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
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    E0992c
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    ELISA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    E0992r
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    Packing:
    96T
    CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    U0992c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    U0992m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    U0992r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    U0992h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    P0992Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    P0992Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Cat.:
    P0992Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Monoclonal Antibody for Human Muscle, skeletal receptor tyrosine-protein kinase
    Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
    Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
    Protein for Human Muscle, skeletal receptor tyrosine-protein kinase
    Protein for Human Muscle, skeletal receptor tyrosine-protein kinase

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    References
    1. 1.
      "Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury."
      Valenzuela D.M. , Stitt T.N. , DiStefano P.S. , Rojas E. , Mattsson K. , Compton D.L. , Nunez L. , Park J.S. , Stark J.L. , Gies D.R. , Thomas S. , LeBeau M.M. , Fernald A.A. , Copeland N.G. , Jenkins N.A. , Burden S.J. , Glass D.J. , Yancopoulos G.D.
      Neuron15:573-584(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING (ISOFORMS 2 AND 3)
    2. 2.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
    4. 4.
      "The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization."
      Bergamin E. , Hallock P.T. , Burden S.J. , Hubbard S.R.
      Mol. Cell39:100-109(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOK7
    5. 5.
      "Development and validation of a method for profiling post-translational modification activities using protein microarrays."
      Del Rincon S.V. , Rogers J. , Widschwendter M. , Sun D. , Sieburg H.B. , Spruck C.
      PLoS ONE5:E11332-E11332(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NEDDYLATION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMS-ACHRD MET-790
    7. 7.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-27; MET-100; GLU-107; GLY-159; SER-222; ILE-413; PHE-629; ALA-644; SER-664; LEU-696; ASP-782; SER-819; LEU-829 AND HIS-858
    8. 8.
      "Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction."
      Maselli R.A. , Arredondo J. , Cagney O. , Ng J.J. , Anderson J.A. , Williams C. , Gerke B.J. , Soliven B. , Wollmann R.L.
      Hum. Mol. Genet.19:2370-2379(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMS-ACHRD ILE-605 AND VAL-727;CHARACTERIZATION OF VARIANTS CMS-ACHRD ILE-605 AND VAL-727
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