Protein name:
Myc proto-oncogene protein ;
Alternative:
Proto-oncogene c-Myc ;Class E basic helix-loop-helix protein 39 (bHLHe39) ;Transcription factor p64 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2.
Function:
Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
Subcellular Location:
Nucleus
nucleoplasm
Nucleus
nucleolus
Protein Attributes:
50:
MPLNVSFTNR | NYDLDYDSVQ | PYFYCDEEEN | FYQQQQQSEL | QPPAPSEDIW |
100:
KKFELLPTPP | LSPSRRSGLC | SPSYVAVTPF | SLRGDNDGGG | GSFSTADQLE |
150:
MVTELLGGDM | VNQSFICDPD | DETFIKNIII | QDCMWSGFSA | AAKLVSEKLA |
200:
SYQAARKDSG | SPNPARGHSV | CSTSSLYLQD | LSAAASECID | PSVVFPYPLN |
250:
DSSSPKSCAS | QDSSAFSPSS | DSLLSSTESS | PQGSPEPLVL | HEETPPTTSS |
300:
DSEEEQEDEE | EIDVVSVEKR | QAPGKRSESG | SPSAGGHSKP | PHSPLVLKRC |
350:
HVSTHQHNYA | APPSTRKDYP | AAKRVKLDSV | RVLRQISNNR | KCTSPRSSDT |
400:
EENVKRRTHN | VLERQRRNEL | KRSFFALRDQ | IPELENNEKA | PKVVILKKAT |
439:
AYILSVQAEE | QKLISEEDLL | RKRREQLKHK | LEQLRNSCA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Dog
Human
Pig
Chicken
Bovine
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
ELISA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
CLIA Kit for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Polyclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Monoclonal Antibody for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
Protein for Human Myc proto-oncogene protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Uterus .
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Tenzin P.
,
Topham K.
,
Venkataraman V.
,
Wen G.
,
Yamazaki S.
,
Young S.K.
,
Zeng Q.
,
Zimmer A.R.
,
Rosenthal A.
,
Birren B.W.
,
Platzer M.
,
Shimizu N.
,
Lander E.S.
more...
Nature439:331-335(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Cervix .
tissue :
Placenta .
tissue :
Testis .
16.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-170 (ISOFORM 1)
tissue :
Promyelocytic leukemia .
17.
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Cited for : INVOLVEMENT IN BURKITT LYMPHOMA
18.
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Cited for : PHOSPHORYLATION
19.
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Cited for : INVOLVEMENT IN BURKITT LYMPHOMA;VARIANTS ASP-39; SER-57; ALA-59 AND THR-86
20.
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Cited for : PHOSPHORYLATION AT THR-58 AND SER-62
21.
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Cited for : GLYCOSYLATION AT THR-58
22.
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Cited for : PHOSPHORYLATION AT THR-8
23.
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Cited for : UBIQUITINATION;INTERACTION WITH FBXW7;PHOSPHORYLATION AT THR-58 AND SER-62;MUTAGENESIS OF THR-58 AND SER-62
24.
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Cited for : ACETYLATION AT LYS-143; LYS-157; LYS-275; LYS-317; LYS-323 AND LYS-371;IDENTIFICATION BY MASS SPECTROMETRY
25.
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Cited for : INTERACTION WITH TAF1C
26.
"PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation."
Yu M.
,
Schreek S.
,
Cerni C.
,
Schamberger C.
,
Lesniewicz K.
,
Poreba E.
,
Vervoorts J.
,
Walsemann G.
,
Groetzinger J.
,
Kremmer E.
,
Mehraein Y.
,
Mertsching J.
,
Kraft R.
,
Austen M.
,
Luescher-Firzlaff J.
,
Luescher B.
Oncogene24:1982-1993(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH PARP10
27.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
28.
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Cited for : BIOTECHNOLOGY
29.
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Cited for : UBIQUITINATION;DEUBIQUITINATION BY USP28;INTERACTION WITH FBXW7
30.
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Cited for : INTERACTION WITH KDM5A AND KDM5B
31.
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Cited for : INTERACTION WITH NO66
32.
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Cited for : UBIQUITINATION;DEUBIQUITINATION BY USP28;INTERACTION WITH FBXW7;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-58 AND SER-62;MUTAGENESIS OF THR-58 AND SER-62
33.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58; SER-62 AND SER-71;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
34.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.
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Cited for : REVIEW ON SENESCENCE;PHOSPHORYLATION AT SER-62 BY CDK2;MUTAGENESIS OF THR-58 AND SER-62
37.
"Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation."
Hydbring P.
,
Bahram F.
,
Su Y.
,
Tronnersjoe S.
,
Hoegstrand K.
,
von der Lehr N.
,
Sharifi H.R.
,
Lilischkis R.
,
Hein N.
,
Wu S.
,
Vervoorts J.
,
Henriksson M.
,
Grandien A.
,
Luescher B.
,
Larsson L.-G.
Proc. Natl. Acad. Sci. U.S.A.107:58-63(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-62 BY CDK2;MUTAGENESIS OF THR-58 AND SER-62
38.
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Cited for : UBIQUITINATION
39.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-161;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
40.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-58 AND SER-62;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
41.
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Cited for : PHOSPHORYLATION AT SER-62;MUTAGENESIS OF SER-62
42.
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Cited for : STRUCTURE BY NMR OF 402-434 IN COMPLEX WITH MAX