Gene name:
MYH11 (KIAA0866) ;
Protein name:
Myosin-11 ;
Alternative:
Myosin heavy chain, smooth muscle isoform ;Myosin heavy chain 11 ;SMMHC ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Function:
Muscle contraction.
Subcellular Location:
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
Protein Attributes:
50:
MAQKGQLSDD | EKFLFVDKNF | INSPVAQADW | AAKRLVWVPS | EKQGFEAASI |
100:
KEEKGDEVVV | ELVENGKKVT | VGKDDIQKMN | PPKFSKVEDM | AELTCLNEAS |
150:
VLHNLRERYF | SGLIYTYSGL | FCVVVNPYKH | LPIYSEKIVD | MYKGKKRHEM |
200:
PPHIYAIADT | AYRSMLQDRE | DQSILCTGES | GAGKTENTKK | VIQYLAVVAS |
250:
SHKGKKDTSI | TGELEKQLLQ | ANPILEAFGN | AKTVKNDNSS | RFGKFIRINF |
300:
DVTGYIVGAN | IETYLLEKSR | AIRQARDERT | FHIFYYMIAG | AKEKMRSDLL |
350:
LEGFNNYTFL | SNGFVPIPAA | QDDEMFQETV | EAMAIMGFSE | EEQLSILKVV |
400:
SSVLQLGNIV | FKKERNTDQA | SMPDNTAAQK | VCHLMGINVT | DFTRSILTPR |
450:
IKVGRDVVQK | AQTKEQADFA | VEALAKATYE | RLFRWILTRV | NKALDKTHRQ |
500:
GASFLGILDI | AGFEIFEVNS | FEQLCINYTN | EKLQQLFNHT | MFILEQEEYQ |
550:
REGIEWNFID | FGLDLQPCIE | LIERPNNPPG | VLALLDEECW | FPKATDKSFV |
600:
EKLCTEQGSH | PKFQKPKQLK | DKTEFSIIHY | AGKVDYNASA | WLTKNMDPLN |
650:
DNVTSLLNAS | SDKFVADLWK | DVDRIVGLDQ | MAKMTESSLP | SASKTKKGMF |
700:
RTVGQLYKEQ | LGKLMTTLRN | TTPNFVRCII | PNHEKRSGKL | DAFLVLEQLR |
750:
CNGVLEGIRI | CRQGFPNRIV | FQEFRQRYEI | LAANAIPKGF | MDGKQACILM |
800:
IKALELDPNL | YRIGQSKIFF | RTGVLAHLEE | ERDLKITDVI | MAFQAMCRGY |
850:
LARKAFAKRQ | QQLTAMKVIQ | RNCAAYLKLR | NWQWWRLFTK | VKPLLQVTRQ |
900:
EEEMQAKEDE | LQKTKERQQK | AENELKELEQ | KHSQLTEEKN | LLQEQLQAET |
950:
ELYAEAEEMR | VRLAAKKQEL | EEILHEMEAR | LEEEEDRGQQ | LQAERKKMAQ |
1000:
QMLDLEEQLE | EEEAARQKLQ | LEKVTAEAKI | KKLEDEILVM | DDQNNKLSKE |
1050:
RKLLEERISD | LTTNLAEEEE | KAKNLTKLKN | KHESMISELE | VRLKKEEKSR |
1100:
QELEKLKRKL | EGDASDFHEQ | IADLQAQIAE | LKMQLAKKEE | ELQAALARLD |
1150:
DEIAQKNNAL | KKIRELEGHI | SDLQEDLDSE | RAARNKAEKQ | KRDLGEELEA |
1200:
LKTELEDTLD | STATQQELRA | KREQEVTVLK | KALDEETRSH | EAQVQEMRQK |
1250:
HAQAVEELTE | QLEQFKRAKA | NLDKNKQTLE | KENADLAGEL | RVLGQAKQEV |
1300:
EHKKKKLEAQ | VQELQSKCSD | GERARAELND | KVHKLQNEVE | SVTGMLNEAE |
1350:
GKAIKLAKDV | ASLSSQLQDT | QELLQEETRQ | KLNVSTKLRQ | LEEERNSLQD |
1400:
QLDEEMEAKQ | NLERHISTLN | IQLSDSKKKL | QDFASTVEAL | EEGKKRFQKE |
1450:
IENLTQQYEE | KAAAYDKLEK | TKNRLQQELD | DLVVDLDNQR | QLVSNLEKKQ |
1500:
RKFDQLLAEE | KNISSKYADE | RDRAEAEARE | KETKALSLAR | ALEEALEAKE |
1550:
ELERTNKMLK | AEMEDLVSSK | DDVGKNVHEL | EKSKRALETQ | MEEMKTQLEE |
1600:
LEDELQATED | AKLRLEVNMQ | ALKGQFERDL | QARDEQNEEK | RRQLQRQLHE |
1650:
YETELEDERK | QRALAAAAKK | KLEGDLKDLE | LQADSAIKGR | EEAIKQLRKL |
1700:
QAQMKDFQRE | LEDARASRDE | IFATAKENEK | KAKSLEADLM | QLQEDLAAAE |
1750:
RARKQADLEK | EELAEELASS | LSGRNALQDE | KRRLEARIAQ | LEEELEEEQG |
1800:
NMEAMSDRVR | KATQQAEQLS | NELATERSTA | QKNESARQQL | ERQNKELRSK |
1850:
LHEMEGAVKS | KFKSTIAALE | AKIAQLEEQV | EQEAREKQAA | TKSLKQKDKK |
1900:
LKEILLQVED | ERKMAEQYKE | QAEKGNARVK | QLKRQLEEAE | EESQRINANR |
1950:
RKLQRELDEA | TESNEAMGRE | VNALKSKLRR | GNETSFVPSR | RSGGRRVIEN |
1972:
ADGSEEETDT | RDADFNGTKA | SE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Human
Rat
Rabbit
Mouse
Chicken
ELISA Kit for Human Myosin-11
ELISA Kit for Human Myosin-11
ELISA Kit for Human Myosin-11
ELISA Kit for Human Myosin-11
ELISA Kit for Human Myosin-11
ELISA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
CLIA Kit for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Polyclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Monoclonal Antibody for Human Myosin-11
Protein for Human Myosin-11
Protein for Human Myosin-11
Protein for Human Myosin-11
Protein for Human Myosin-11
Protein for Human Myosin-11
Protein for Human Myosin-11
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);TISSUE SPECIFICITY
2.
"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
tissue :
Colon .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 885-1972 (ISOFORM 1/2)
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Submitted (1992-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1093-1972 (ISOFORM 1/2)
tissue :
Hippocampus .
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Wu C.
,
Appella E.
,
Hunt D.F.
J. Proteome Res.5:3135-3144(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1954;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
"Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus."
Zhu L.
,
Vranckx R.
,
Khau Van Kien P.
,
Lalande A.
,
Boisset N.
,
Mathieu F.
,
Wegman M.
,
Glancy L.
,
Gasc J.-M.
,
Brunotte F.
,
Bruneval P.
,
Wolf J.-E.
,
Michel J.-B.
,
Jeunemaitre X.
Nat. Genet.38:343-349(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS AAT4 1241-ARG--LEU-1264 DEL AND GLN-1758