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Index > Protein center > ULBP2(Gene name) > Human
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  • ULBP2 (Gene name),
  • NKG2D ligand 2 (Protein name ),  N2DL2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ULBP2(UNQ463/PRO791;N2DL2;RAET1H);
    Protein name:
    NKG2D ligand 2(N2DL-2;NKG2DL2);
    Alternative:
    Retinoic acid early transcript 1H;ALCAN-alpha;UL16-binding protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
    Function:
    Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor Secreted
    Protein Attributes:
    Sequence length:
    246
    Sequence:
    50:
    MAAAAATKIL | LCLPLLLLLS | GWSRAGRADP | HSLCYDITVI | PKFRPGPRWC | 
    100:
    AVQGQVDEKT | FLHYDCGNKT | VTPVSPLGKK | LNVTTAWKAQ | NPVLREVVDI | 
    150:
    LTEQLRDIQL | ENYTPKEPLT | LQARMSCEQK | AEGHSSGSWQ | FSFDGQIFLL | 
    200:
    FDSEKRMWTT | VHPGARKMKE | KWENDKVVAM | SFHYFSMGDC | IGWLEDFLMG | 
    246:
    MDSTLEPSAG | APLAMSSGTT | QLRATATTLI | LCCLLIILPC | FILPGI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human N2DL-2
    Cat.:
    E2254h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human N2DL-2
    Cat.:
    U2254h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human N2DL-2
    Cat.:
    P2254Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human N2DL-2
    Protein for Human N2DL-2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor."
      Cosman D. , Mullberg J. , Sutherland C.L. , Chin W. , Armitage R. , Fanslow W. , Kubin M. , Chalupny N.J.
      Immunity14:123-133(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GPI-ANCHOR AT SER-216
    2. 2.
      "A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers."
      Onda H. , Ohkubo S. , Shintani Y. , Ogi K. , Kikuchi K. , Tanaka H. , Yamamoto K. , Tsuji I. , Ishibashi Y. , Yamada T. , Kitada C. , Suzuki N. , Sawada H. , Nishimura O. , Fujino M.
      Biochem. Biophys. Res. Commun.285:235-243(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF N-TERMINUS;GPI-ANCHOR AT SER-216;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF 208-SER--GLY-210 AND 216-SER--GLY-218
      tissue: Endometrial tumor.
    3. 3.
      "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3."
      Radosavljevic M. , Cuillerier B. , Wilson M.J. , Clement O. , Wicker S. , Gilfillan S. , Beck S. , Trowsdale J. , Bahram S.
      Genomics79:114-123(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    8. 8.
      "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells."
      Sutherland C.L. , Chalupny N.J. , Schooley K. , VandenBos T. , Kubin M. , Cosman D.
      J. Immunol.168:671-679(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A LIGAND FOR KLRK1
    9. 9.
      "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity."
      Dunn C. , Chalupny N.J. , Sutherland C.L. , Dosch S. , Sivakumar P.V. , Johnson D.C. , Cosman D.
      J. Exp. Med.197:1427-1439(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UL16;SUBCELLULAR LOCATION
    10. 10.
      "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer."
      Cerwenka A. , Lanier L.L.
      Tissue Antigens61:335-343(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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