Gene name:
ULBP2(UNQ463/PRO791;N2DL2;RAET1H);
Protein name:
NKG2D ligand 2(N2DL-2;NKG2DL2);
Alternative:
Retinoic acid early transcript 1H;ALCAN-alpha;UL16-binding protein 2;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.
Function:
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Secreted
Protein Attributes:
50:
MAAAAATKIL | LCLPLLLLLS | GWSRAGRADP | HSLCYDITVI | PKFRPGPRWC |
100:
AVQGQVDEKT | FLHYDCGNKT | VTPVSPLGKK | LNVTTAWKAQ | NPVLREVVDI |
150:
LTEQLRDIQL | ENYTPKEPLT | LQARMSCEQK | AEGHSSGSWQ | FSFDGQIFLL |
200:
FDSEKRMWTT | VHPGARKMKE | KWENDKVVAM | SFHYFSMGDC | IGWLEDFLMG |
246:
MDSTLEPSAG | APLAMSSGTT | QLRATATTLI | LCCLLIILPC | FILPGI
Vaild Sequence:
Related Databases
Uniprot:
