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Index > Protein center > Nampt(Gene name) > Mouse
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  • Nampt (Gene name),
  • Nicotinamide phosphoribosyltransferase (Protein name ),  NAMPT_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Nampt(Pbef1);
    Protein name:
    Nicotinamide phosphoribosyltransferase(NAmPRTase;Nampt);
    Alternative:
    Visfatin;Pre-B-cell colony-enhancing factor 1 homolog(PBEF);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    491
    Sequence:
    50:
    MNAAAEAEFN | ILLATDSYKV | THYKQYPPNT | SKVYSYFECR | EKKTENSKVR | 
    100:
    KVKYEETVFY | GLQYILNKYL | KGKVVTKEKI | QEAKEVYREH | FQDDVFNERG | 
    150:
    WNYILEKYDG | HLPIEVKAVP | EGSVIPRGNV | LFTVENTDPE | CYWLTNWIET | 
    200:
    ILVQSWYPIT | VATNSREQKK | ILAKYLLETS | GNLDGLEYKL | HDFGYRGVSS | 
    250:
    QETAGIGASA | HLVNFKGTDT | VAGIALIKKY | YGTKDPVPGY | SVPAAEHSTI | 
    300:
    TAWGKDHEKD | AFEHIVTQFS | SVPVSVVSDS | YDIYNACEKI | WGEDLRHLIV | 
    350:
    SRSTEAPLII | RPDSGNPLDT | VLKVLDILGK | KFPVTENSKG | YKLLPPYLRV | 
    400:
    IQGDGVDINT | LQEIVEGMKQ | KKWSIENVSF | GSGGALLQKL | TRDLLNCSFK | 
    450:
    CSYVVTNGLG | VNVFKDPVAD | PNKRSKKGRL | SLHRTPAGNF | VTLEEGKGDL | 
    491:
    EEYGHDLLHT | VFKNGKVTKS | YSFDEVRKNA | QLNIEQDVAP | H
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NAmPRTase
    Cat.:
    E0638p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse NAmPRTase
    Cat.:
    E0638r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse NAmPRTase
    Cat.:
    E0638m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse NAmPRTase
    Cat.:
    E0638h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NAmPRTase
    Cat.:
    U0638h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NAmPRTase
    Cat.:
    U0638m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NAmPRTase
    Cat.:
    U0638r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NAmPRTase
    Cat.:
    U0638p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NAmPRTase
    Cat.:
    P0638Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NAmPRTase
    Cat.:
    P0638Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NAmPRTase
    Cat.:
    P0638Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NAmPRTase
    Monoclonal Antibody for Mouse NAmPRTase
    Monoclonal Antibody for Mouse NAmPRTase
    Monoclonal Antibody for Mouse NAmPRTase
    Monoclonal Antibody for Mouse NAmPRTase
    Protein for Mouse NAmPRTase
    Protein for Mouse NAmPRTase
    Protein for Mouse NAmPRTase
    Protein for Mouse NAmPRTase
    Cat.:
    R0638h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data
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    12% SDS-PAGE analysis

                12% SDS-PAGE analysis


    wb

            Western blot - Anti-NAMPT antibody

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis."
      Rongvaux A. , Shea R.J. , Mulks M.H. , Gigot D. , Urbain J. , Leo O. , Andris F.
      Eur. J. Immunol.32:3225-3234(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
      tissue: T-cell.
    2. 2.
      "The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells."
      Revollo J.R. , Grimm A.A. , Imai S.
      J. Biol. Chem.279:50754-50763(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];BIOPHYSICOCHEMICAL PROPERTIES;FUNCTION
      strain: BALB/c.
      tissue: Liver.
    3. 3.
      "Mus musculus pre-B-cell colony-enhancing factor (PBEF) mRNA."
      Samal B.B. , Sun N. , Sun Y.
      Submitted (2000-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      strain: FVB/N.
      tissue: Mammary tumor.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-368
      strain: C57BL/6J.
      tissue: Head.
    6. 6.
      "Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis."
      Ramsey K.M. , Yoshino J. , Brace C.S. , Abrassart D. , Kobayashi Y. , Marcheva B. , Hong H.K. , Chong J.L. , Buhr E.D. , Lee C. , Takahashi J.S. , Imai S. , Bass J.
      Science324:651-654(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    7. 7.
      "Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1."
      Nakahata Y. , Sahar S. , Astarita G. , Kaluzova M. , Sassone-Corsi P.
      Science324:654-657(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents."
      Khan J.A. , Tao X. , Tong L.
      Nat. Struct. Mol. Biol.13:582-588(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);SUBUNIT
    9. 9.
      "Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme."
      Wang T. , Zhang X. , Bheda P. , Revollo J.R. , Imai S. , Wolberger C.
      Nat. Struct. Mol. Biol.13:661-662(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NICOTINAMIDE MONONUCLEOTIDE;SUBUNIT
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