Protein name:
Nuclear receptor corepressor 2(N-CoR2);
Alternative:
SMAP270;CTG repeat protein 26;T3 receptor-associating factor(TRAC);Silencing mediator of retinoic acid and thyroid hormone receptor(SMRT);Thyroid-, retinoic-acid-receptor-associated corepressor;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BCL6, HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SRMT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity.
Function:
Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSGSTQPVAQ | TWRATEPRYP | PHSLSYPVQI | ARTHTDVGLL | EYQHHSRDYA |
100:
SHLSPGSIIQ | PQRRRPSLLS | EFQPGNERSQ | ELHLRPESHS | YLPELGKSEM |
150:
EFIESKRPRL | ELLPDPLLRP | SPLLATGQPA | GSEDLTKDRS | LTGKLEPVSP |
200:
PSPPHTDPEL | ELVPPRLSKE | ELIQNMDRVD | REITMVEQQI | SKLKKKQQQL |
250:
EEEAAKPPEP | EKPVSPPPIE | SKHRSLVQII | YDENRKKAEA | AHRILEGLGP |
300:
QVELPLYNQP | SDTRQYHENI | KINQAMRKKL | ILYFKRRNHA | RKQWEQKFCQ |
350:
RYDQLMEAWE | KKVERIENNP | RRRAKESKVR | EYYEKQFPEI | RKQRELQERM |
400:
QSRVGQRGSG | LSMSAARSEH | EVSEIIDGLS | EQENLEKQMR | QLAVIPPMLY |
450:
DADQQRIKFI | NMNGLMADPM | KVYKDRQVMN | MWSEQEKETF | REKFMQHPKN |
500:
FGLIASFLER | KTVAECVLYY | YLTKKNENYK | SLVRRSYRRR | GKSQQQQQQQ |
550:
QQQQQQQQQQ | PMPRSSQEEK | DEKEKEKEAE | KEEEKPEVEN | DKEDLLKEKT |
600:
DDTSGEDNDE | KEAVASKGRK | TANSQGRRKG | RITRSMANEA | NSEEAITPQQ |
650:
SAELASMELN | ESSRWTEEEM | ETAKKGLLEH | GRNWSAIARM | VGSKTVSQCK |
700:
NFYFNYKKRQ | NLDEILQQHK | LKMEKERNAR | RKKKKAPAAA | SEEAAFPPVV |
750:
EDEEMEASGV | SGNEEEMVEE | AEALHASGNE | VPRGECSGPA | TVNNSSDTES |
800:
IPSPHTEAAK | DTGQNGPKPP | ATLGADGPPP | GPPTPPPEDI | PAPTEPTPAS |
850:
EATGAPTPPP | APPSPSAPPP | VVPKEEKEEE | TAAAPPVEEG | EEQKPPAAEE |
900:
LAVDTGKAEE | PVKSECTEEA | EEGPAKGKDA | EAAEATAEGA | LKAEKKEGGS |
950:
GRATTAKSSG | APQDSDSSAT | CSADEVDEAE | GGDKNRLLSP | RPSLLTPTGD |
1000:
PRANASPQKP | LDLKQLKQRA | AAIPPIQVTK | VHEPPREDAA | PTKPAPPAPP |
1050:
PPQNLQPESD | APQQPGSSPR | GKSRSPAPPA | DKEAEKPVFF | PAFAAEAQKL |
1100:
PGDPPCWTSG | LPFPVPPREV | IKASPHAPDP | SAFSYAPPGH | PLPLGLHDTA |
1150:
RPVLPRPPTI | SNPPPLISSA | KHPSVLERQI | GAISQGMSVQ | LHVPYSEHAK |
1200:
APVGPVTMGL | PLPMDPKKLA | PFSGVKQEQL | SPRGQAGPPE | SLGVPTAQEA |
1250:
SVLRGTALGS | VPGGSITKGI | PSTRVPSDSA | ITYRGSITHG | TPADVLYKGT |
1300:
ITRIIGEDSP | SRLDRGREDS | LPKGHVIYEG | KKGHVLSYEG | GMSVTQCSKE |
1350:
DGRSSSGPPH | ETAAPKRTYD | MMEGRVGRAI | SSASIEGLMG | RAIPPERHSP |
1400:
HHLKEQHHIR | GSITQGIPRS | YVEAQEDYLR | REAKLLKREG | TPPPPPPSRD |
1450:
LTEAYKTQAL | GPLKLKPAHE | GLVATVKEAG | RSIHEIPREE | LRHTPELPLA |
1500:
PRPLKEGSIT | QGTPLKYDTG | ASTTGSKKHD | VRSLIGSPGR | TFPPVHPLDV |
1550:
MADARALERA | CYEESLKSRP | GTASSSGGSI | ARGAPVIVPE | LGKPRQSPLT |
1600:
YEDHGAPFAG | HLPRGSPVTT | REPTPRLQEG | SLSSSKASQD | RKLTSTPREI |
1650:
AKSPHSTVPE | HHPHPISPYE | HLLRGVSGVD | LYRSHIPLAF | DPTSIPRGIP |
1700:
LDAAAAYYLP | RHLAPNPTYP | HLYPPYLIRG | YPDTAALENR | QTIINDYITS |
1750:
QQMHHNAATA | MAQRADMLRG | LSPRESSLAL | NYAAGPRGII | DLSQVPHLPV |
1800:
LVPPTPGTPA | TAMDRLAYLP | TAPQPFSSRH | SSSPLSPGGP | THLTKPTTTS |
1850:
SSERERDRDR | ERDRDREREK | SILTSTTTVE | HAPIWRPGTE | QSSGSSGSSG |
1900:
GGGGSSSRPA | SHSHAHQHSP | ISPRTQDALQ | QRPSVLHNTG | MKGIITAVEP |
1950:
STPTVLRSTS | TSSPVRPAAT | FPPATHCPLG | GTLDGVYPTL | MEPVLLPKEA |
2000:
PRVARPERPR | ADTGHAFLAK | PPARSGLEPA | SSPSKGSEPR | PLVPPVSGHA |
2050:
TIARTPAKNL | APHHASPDPP | APPASASDPH | REKTQSKPFS | IQELELRSLG |
2100:
YHGSSYSPEG | VEPVSPVSSP | SLTHDKGLPK | HLEELDKSHL | EGELRPKQPG |
2150:
PVKLGGEAAH | LPHLRPLPES | QPSSSPLLQT | APGVKGHQRV | VTLAQHISEV |
2200:
ITQDYTRHHP | QQLSAPLPAP | LYSFPGASCP | VLDLRRPPSD | LYLPPPDHGA |
2250:
PARGSPHSEG | GKRSPEPNKT | SVLGGGEDGI | EPVSPPEGMT | EPGHSRSAVY |
2300:
PLLYRDGEQT | EPSRMGSKSP | GNTSQPPAFF | SKLTESNSAM | VKSKKQEINK |
2350:
KLNTHNRNEP | EYNISQPGTE | IFNMPAITGT | GLMTYRSQAV | QEHASTNMGL |
2400:
EAIIRKALMG | KYDQWEESPP | LSANAFNPLN | ASASLPAAMP | ITAADGRSDH |
2450:
TLTSPGGGGK | AKVSGRPSSR | KAKSPAPGLA | SGDRPPSVSS | VHSEGDCNRR |
2500:
TPLTNRVWED | RPSSAGSTPF | PYNPLIMRLQ | AGVMASPPPP | GLPAGSGPLA |
2525:
GPHHAWDEEP | KPLLCSQYET | LSDSE
Vaild Sequence:
Related Databases
Uniprot: