Gene name:
NME1 (NDPKA;NM23) ;
Protein name:
Nucleoside diphosphate kinase A (NDK A;NDP kinase A) ;
Alternative:
Metastasis inhibition factor nm23 ;Granzyme A-activated DNase (GAAD) ;nm23-H1 ;Tumor metastatic process-associated protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE.
Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Subcellular Location:
Cytoplasm
Nucleus
Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Protein Attributes:
50:
MANCERTFIA | IKPDGVQRGL | VGEIIKRFEQ | KGFRLVGLKF | MQASEDLLKE |
100:
HYVDLKDRPF | FAGLVKYMHS | GPVVAMVWEG | LNVVKTGRVM | LGETNPADSK |
150:
PGTIRGDFCI | QVGRNIIHGS | DSVESAEKEI | GLWFHPEELV | DYTSCAQNWI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Dog
Mouse
ELISA Kit for Human NDK A
ELISA Kit for Human NDK A
ELISA Kit for Human NDK A
ELISA Kit for Human NDK A
Polyclonal Antibody for Human NDK A
Polyclonal Antibody for Human NDK A
Polyclonal Antibody for Human NDK A
Polyclonal Antibody for Human NDK A
Monoclonal Antibody for Human NDK A
Monoclonal Antibody for Human NDK A
Monoclonal Antibody for Human NDK A
Monoclonal Antibody for Human NDK A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE (ISOFORM 1);SUBUNIT;ACTIVE SITE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Lung .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 7-18; 40-49 AND 89-94 (ISOFORMS 1/2);DISCUSSION OF THE ROLE IN TUMOR PROGRESSION
tissue :
Neuroblastoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 7-26; 40-49; 57-85 AND 89-128 (ISOFORMS 1/2);IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
tissue :
Fetal brain cortex .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF PRO-96; HIS-118 AND SER-120
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ENZYME REGULATION;INTERACTION WITH SET;IDENTIFICATION IN THE SET COMPLEX
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORM 3);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TREX1;IDENTIFICATION IN THE SET COMPLEX
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PRUNE
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS);MUTAGENESIS OF PHE-60 AND HIS-118
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLY-120