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Index > Protein center > NME1(Gene name) > Human
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  • NME1 (Gene name),
  • Nucleoside diphosphate kinase A (Protein name ),  NDKA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NME1(NDPKA;NM23);
    Protein name:
    Nucleoside diphosphate kinase A(NDK A;NDP kinase A);
    Alternative:
    Metastasis inhibition factor nm23;Granzyme A-activated DNase(GAAD);nm23-H1;Tumor metastatic process-associated protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE.
    Function:
    Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
    Subcellular Location:
    Cytoplasm Nucleus Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
    Protein Attributes:
    Sequence length:
    152
    Sequence:
    50:
    MANCERTFIA | IKPDGVQRGL | VGEIIKRFEQ | KGFRLVGLKF | MQASEDLLKE | 
    100:
    HYVDLKDRPF | FAGLVKYMHS | GPVVAMVWEG | LNVVKTGRVM | LGETNPADSK | 
    150:
    PGTIRGDFCI | QVGRNIIHGS | DSVESAEKEI | GLWFHPEELV | DYTSCAQNWI | 
    152:
    YE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
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    ELISA Kit for Human NDK A
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    ELISA Kit for Human NDK A
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    ELISA Kit for Human NDK A
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    ELISA Kit for Human NDK A
    Cat.:
    E14300m
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    Packing:
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    CLIA Kit for Human NDK A
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    CLIA Kit for Human NDK A
    MSDS:
    Please sign in first.
    CLIA Kit for Human NDK A
    Cat.:
    U14300m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NDK A
    Cat.:
    U14300h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NDK A
    Polyclonal Antibody for Human NDK A
    Polyclonal Antibody for Human NDK A
    Polyclonal Antibody for Human NDK A
    Monoclonal Antibody for Human NDK A
    Monoclonal Antibody for Human NDK A
    Monoclonal Antibody for Human NDK A
    Monoclonal Antibody for Human NDK A
    Protein for Human NDK A
    Protein for Human NDK A
    Protein for Human NDK A
    Protein for Human NDK A

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    References
    1. 1.
      "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development."
      Rosengard A.M. , Krutzsch H.C. , Shearn A. , Biggs J.R. , Barker E. , Margulies I.M.K. , King C.R. , Liotta L.A. , Steeg P.S.
      Nature342:177-180(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme."
      Gilles A.-M. , Presecan E. , Vonica A. , Lascu I.
      J. Biol. Chem.266:8784-8789(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE (ISOFORM 1);SUBUNIT;ACTIVE SITE
    3. 3.
      "Mutation in the nm23 gene is associated with metastasis in colorectal cancer."
      Wang L. , Patel U. , Ghosh L. , Chen H.C. , Banerjee S.
      Cancer Res.53:717-720(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1."
      Dooley S. , Seib T. , Engel M. , Theisinger B. , Janz H. , Piontek K. , Zang K.D. , Welter C.
      Hum. Genet.93:63-66(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "Isolation and characterization of a novel human NM23-H1B gene, a different transcript of NM23-H1."
      Ni X. , Gu S. , Dai J. , Cheng H. , Guo L. , Li L. , Ji C. , Xie Y. , Ying K. , Mao Y.
      J. Hum. Genet.48:96-100(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
    10. 11.
      "High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification."
      Hailat N. , Keim D.R. , Melhem R.F. , Zhu X.X. , Eckerskorn C. , Brodeur G.M. , Reynolds C.P. , Seeger R.C. , Lottspeich F. , Strahler J.R. , Hanash S.J.
      J. Clin. Invest.88:341-345(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-18; 40-49 AND 89-94 (ISOFORMS 1/2);DISCUSSION OF THE ROLE IN TUMOR PROGRESSION
      tissue: Neuroblastoma.
    11. 12.
      Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-26; 40-49; 57-85 AND 89-128 (ISOFORMS 1/2);IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    12. 13.
      "Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells."
      MacDonald N.J. , Freije J.M. , Stracke M.L. , Manrow R.E. , Steeg P.S.
      J. Biol. Chem.271:25107-25116(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF PRO-96; HIS-118 AND SER-120
    13. 14.
      "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display."
      Manda R. , Kohno T. , Matsuno Y. , Takenoshita S. , Kuwano H. , Yokota J.
      Genomics61:5-14(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 15.
      "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."
      Fan Z. , Beresford P.J. , Oh D.Y. , Zhang D. , Lieberman J.
      Cell112:659-672(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;INTERACTION WITH SET;IDENTIFICATION IN THE SET COMPLEX
    15. 16.
      "Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV."
      Valentijn L.J. , Koster J. , Versteeg R.
      Genomics87:483-489(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 3);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    16. 17.
      "The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."
      Chowdhury D. , Beresford P.J. , Zhu P. , Zhang D. , Sung J.S. , Demple B. , Perrino F.W. , Lieberman J.
      Mol. Cell23:133-142(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TREX1;IDENTIFICATION IN THE SET COMPLEX
    17. 18.
      "Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility."
      Garzia L. , D'Angelo A. , Amoresano A. , Knauer S.K. , Cirulli C. , Campanella C. , Stauber R.H. , Steegborn C. , Iolascon A. , Zollo M.
      Oncogene27:1853-1864(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRUNE
    18. 19.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    19. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 21.
      "Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor."
      Min K. , Song H.K. , Chang C. , Kim S.Y. , Lee K.J. , Suh S.W.
      Proteins46:340-342(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    21. 22.
      "Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases."
      Chen Y. , Gallois-Montbrun S. , Schneider B. , Veron M. , Morera S. , Deville-Bonne D. , Janin J.
      J. Mol. Biol.332:915-926(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS);MUTAGENESIS OF PHE-60 AND HIS-118
    22. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-120
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