Protein name:
Netrin-1 ;
Alternative:
Epididymis tissue protein Li 131P ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D.
Function:
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MMRAVWEALA | ALAAVACLVG | AVRGGPGLSM | FAGQAAQPDP | CSDENGHPRR |
100:
CIPDFVNAAF | GKDVRVSSTC | GRPPARYCVV | SERGEERLRS | CHLCNASDPK |
150:
KAHPPAFLTD | LNNPHNLTCW | QSENYLQFPH | NVTLTLSLGK | KFEVTYVSLQ |
200:
FCSPRPESMA | IYKSMDYGRT | WVPFQFYSTQ | CRKMYNRPHR | APITKQNEQE |
250:
AVCTDSHTDM | RPLSGGLIAF | STLDGRPSAH | DFDNSPVLQD | WVTATDIRVA |
300:
FSRLHTFGDE | NEDDSELARD | SYFYAVSDLQ | VGGRCKCNGH | AARCVRDRDD |
350:
SLVCDCRHNT | AGPECDRCKP | FHYDRPWQRA | TAREANECVA | CNCNLHARRC |
400:
RFNMELYKLS | GRKSGGVCLN | CRHNTAGRHC | HYCKEGYYRD | MGKPITHRKA |
450:
CKACDCHPVG | AAGKTCNQTT | GQCPCKDGVT | GITCNRCAKG | YQQSRSPIAP |
500:
CIKIPVAPPT | TAASSVEEPE | DCDSYCKASK | GKLKINMKKY | CKKDYAVQIH |
550:
ILKADKAGDW | WKFTVNIISV | YKQGTSRIRR | GDQSLWIRSR | DIACKCPKIK |
600:
PLKKYLLLGN | AEDSPDQSGI | VADKSSLVIQ | WRDTWARRLR | KFQQREKKGK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
Pig
ELISA Kit for Human Netrin-1
ELISA Kit for Human Netrin-1
ELISA Kit for Human Netrin-1
ELISA Kit for Human Netrin-1
ELISA Kit for Human Netrin-1
CLIA Kit for Human Netrin-1
CLIA Kit for Human Netrin-1
CLIA Kit for Human Netrin-1
CLIA Kit for Human Netrin-1
CLIA Kit for Human Netrin-1
Polyclonal Antibody for Human Netrin-1
Polyclonal Antibody for Human Netrin-1
Polyclonal Antibody for Human Netrin-1
Polyclonal Antibody for Human Netrin-1
Polyclonal Antibody for Human Netrin-1
Monoclonal Antibody for Human Netrin-1
Monoclonal Antibody for Human Netrin-1
Monoclonal Antibody for Human Netrin-1
Monoclonal Antibody for Human Netrin-1
Monoclonal Antibody for Human Netrin-1
Protein for Human Netrin-1
Protein for Human Netrin-1
Protein for Human Netrin-1
Protein for Human Netrin-1
Protein for Human Netrin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
J Liu, X Xia, S Xiong, et al.
[2].
G Ramesh, CD Krawczeski, JG Woo, et al.
[3].
C Jayakumar, FL Nauta, SJ Bakker, et al
[4].
G Ramesh, A Berg, C Jayakumar
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH DCC;TISSUE SPECIFICITY;VARIANTS HIS-351 AND GLU-489
tissue :
Brain stem .
tissue :
Liver .
2.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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Loveland J.
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Major J.E.
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Matthews L.
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Mudge J.
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Bradley A.
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Rogers J.
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Lander E.S.
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Nusbaum C.
more...
Nature440:1045-1049(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
Li J.
,
Liu F.
,
Wang H.
,
Liu X.
,
Liu J.
,
Li N.
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Wan F.
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Wang W.
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Zhang C.
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Jin S.
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Liu J.
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Zhu P.
,
Liu Y.
Mol. Cell. Proteomics9:2517-2528(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Epididymis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DSCAM