NFATC1 ELISA Kit for Human(Homo sapiens) | EIAab.comNFATC1 ELISA Kit for Human(Homo sapiens)

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NFATC1 (Gene name),

Nuclear factor of activated T-cells, cytoplasmic 1 (Protein name ), NFAC1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

NFATC1(NFAT2;NFATC);

Protein name:

Nuclear factor of activated T-cells, cytoplasmic 1(NF-ATc1;NFATc1);

Alternative:

NFAT transcription complex cytosolic component(NF-ATc;NFATc);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.

Function:

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Protein Attributes:

Sequence length:

943

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

943:

DGSPNLAPIP | VTVKREPEEL | DQLYLDDVNE | IIRNDLSSTS | THS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.534074

String:

O95644

Pfam:

PF00554

KEGG:

hsa:4772

MIM:

600489

SMR:

O95644

STRING:

9606.ENSP00000327850

Uniprot:

O95644

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ELISA Kit for Human NF-ATc1

Cat.:

E1519h

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96T

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ELISA Kit for Human NF-ATc1

Cat.:

E1519m

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96T

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ELISA Kit for Human NF-ATc1

Cat.:

E1519b

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Packing:

96T

ELISA Kit for Human NF-ATc1

Cat.:

E1519p

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Packing:

96T

CLIA Kit for Human NF-ATc1

Cat.:

U1519b

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MSDS:

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Packing:

96T

CLIA Kit for Human NF-ATc1

Cat.:

U1519m

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MSDS:

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Packing:

96T

CLIA Kit for Human NF-ATc1

Cat.:

U1519p

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Packing:

96T

CLIA Kit for Human NF-ATc1

Cat.:

U1519h

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Packing:

96T

Polyclonal Antibody for Human NF-ATc1

Cat.:

P1519Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human NF-ATc1

Cat.:

P1519Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human NF-ATc1

Monoclonal Antibody for Human NF-ATc1

Protein for Human NF-ATc1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"NF-AT components define a family of transcription factors targeted in T-cell activation."
Northrop J.P. , Ho S.N. , Chen L. , Thomas D.J. , Timmerman L.A. , Nolan G.P. , Admon A. , Crabtree G.R.
Nature369:497-502(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A-ALPHA)
tissue: Peripheral blood lymphocyte.
tissue: T-cell.
2.

"Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc."
Park J. , Takeuchi A. , Sharma S.
J. Biol. Chem.271:20914-20921(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B-BETA)
tissue: B-cell.
3.

Park J. , Takeuchi A. , Sharma S.
J. Biol. Chem.271:33705-33705(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells."
Chuvpilo S. , Zimmer M. , Kerstan A. , Gloeckner J. , Avots A. , Escher C. , Fischer C. , Inashkina I. , Jankevics E. , Berberich-Siebelt F. , Schmitt E. , Serfling E.
Immunity10:261-269(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A-ALPHA; B-ALPHA AND C-BETA)
tissue: B-cell lymphoma.
5.

"Alternative splicing and expression of human and mouse NFAT genes."
Vihma H. , Pruunsild P. , Timmusk T.
Genomics92:279-291(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C-ALPHA; IA-DELTAIX AND IB-DELTAIX);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
6.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A-ALPHA)
tissue: Brain.
9.

"Expression of NFAT-family proteins in normal human T cells."
Lyakh L. , Ghosh P. , Rice N.R.
Mol. Cell. Biol.17:2475-2484(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF ISOFORM A-ALPHA'
10.

"Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3."
Beals C.R. , Sheridan C.M. , Turck C.W. , Gardner P. , Crabtree G.R.
Science275:1930-1934(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY GSK3B
11.

"Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."
Crabtree G.R.
Cell96:611-614(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes."
Chuvpilo S. , Avots A. , Berberich-Siebelt F. , Gloeckner J. , Fischer C. , Kerstan A. , Escher C. , Inashkina I. , Hlubek F. , Jankevics E. , Brabletz T. , Serfling E.
J. Immunol.162:7294-7301(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;CHARACTERIZATION
13.

"Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization."
Porter C.M. , Havens M.A. , Clipstone N.A.
J. Biol. Chem.275:3543-3551(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-172 AND SER-187
14.

"Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3."
Sheridan C.M. , Heist E.K. , Beals C.R. , Crabtree G.R. , Gardner P.
J. Biol. Chem.277:48664-48676(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-245; SER-269 AND SER-294
15.

"A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT."
Gwack Y. , Sharma S. , Nardone J. , Tanasa B. , Iuga A. , Srikanth S. , Okamura H. , Bolton D. , Feske S. , Hogan P.G. , Rao A.
Nature441:646-650(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION
16.

"Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc."
Wolfe S.A. , Zhou P. , Dotsch V. , Chen L. , You A. , Ho S.N. , Crabtree G.R. , Wagner G. , Verdine G.L.
Nature385:172-176(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 416-591
17.

"Solution structure of the core NFATC1/DNA complex."
Zhou P. , Sun L.J. , Dotsch V. , Wagner G. , Verdine G.L.
Cell92:687-696(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 416-591 IN COMPLEX WITH DNA
18.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-315

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