Nuclear factor NF-kappa-B p100 subunit (Protein name
), NFKB2_HUMAN from NCBI database.
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Gene name:
NFKB2(LYT10);
Protein name:
Nuclear factor NF-kappa-B p100 subunit;
Alternative:
H2TF1;DNA-binding factor KBF2;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2;Lymphocyte translocation chromosome 10 protein;Oncogene Lyt-10(Lyt10);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.
Function:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Subcellular Location:
Nucleus
Cytoplasm
Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION;P80HT GENERATION
4.
Rabson A.B.
Submitted (2006-02) to the EMBL/GenBank/DDBJ databases
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Cited for: SEQUENCE REVISION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
NIEHS SNPs program
Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-14; ARG-351 AND ARG-452
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
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Cited for: PROTEIN SEQUENCE OF 459-470; 580-597 AND 636-647 (ISOFORM 1)
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Cited for: FUNCTION;IDENTIFICATION IN THE NF-KAPPA-B RELB-P52 COMPLEX
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Cited for: IDENTIFICATION IN THE NF-KAPPA-B P52-C-REL COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-P52 COMPLEX
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Cited for: COTRANSLATIONAL FOLDING/PROCESSING OF P100;GENERATION OF P52/P100
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Cited for: PHOSPHORYLATION AT SER-713; SER-715 AND SER-717;MUTAGENESIS;DIMERIZATION;PROTEOLYTIC PROCESSING OF P100
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Cited for: PHOSPHORYLATION AT SER-866 AND SER-870;MUTAGENESIS OF SER-866 AND SER-870;PROTEOLYTIC PROCESSING OF P100
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Cited for: CHROMOSOMAL ABERRATIONS;GENERATION OF LB40 AND EB308
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Cited for: IDENTIFICATION IN THE NF-KAPPA-B P65-P52 COMPLEX
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-429;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 37-327