NEFL ELISA Kit for Human(Homo sapiens) | EIAab.comNEFL ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NEFL(Gene name) > Human

NEFL (Gene name),

Neurofilament light polypeptide (Protein name ), NFL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NEFL(NF68;NFL);

Protein name:

Neurofilament light polypeptide(NF-L);

Alternative:

Neurofilament triplet L protein;68 kDa neurofilament protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RGNEF (By similarity). Interacts with TRIM2.

Function:

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

543

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

543:

ESEEAKEEEE | GGEGEEGEET | KEAEEEEKKV | EGAGEEQAAK | KKD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000221169

KEGG:

hsa:4747

UniGene:

Hs.521461

String:

P07196

Pfam:

PF00038

SMR:

P07196

MIM:

162280

Uniprot:

P07196

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ELISA Kit for Human NF-L

Cat.:

E10709h

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96T

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ELISA Kit for Human NF-L

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ELISA Kit for Human NF-L

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ELISA Kit for Human NF-L

Cat.:

E10709m

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96T

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ELISA Kit for Human NF-L

Cat.:

E10709r

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96T

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CLIA Kit for Human NF-L

Cat.:

U10709m

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Packing:

96T

CLIA Kit for Human NF-L

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CLIA Kit for Human NF-L

MSDS:

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CLIA Kit for Human NF-L

Cat.:

U10709h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human NF-L

Cat.:

U10709r

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Packing:

96T

Polyclonal Antibody for Human NF-L

Cat.:

P10709Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human NF-L

Monoclonal Antibody for Human NF-L

Protein for Human NF-L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family."
Julien J.-P. , Grosveld F. , Yazdanbaksh K. , Flavell D. , Meijer D. , Mushynski W.
Biochim. Biophys. Acta909:10-20(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Effects of Charcot-Marie-Tooth-linked mutations of the neurofilament light subunit on intermediate filament formation."
Perez-Olle R. , Leung C.L. , Liem R.K.
J. Cell Sci.115:4937-4946(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

"AP-1 and Krox-24 transcription factors activate the neurofilament light gene promoter in P19 embryonal carcinoma cells."
Pospelov V.A. , Pospelova T.V. , Julien J.-P.
Cell Growth Differ.5:187-196(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11
7.

Lubec G. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 38-54; 213-224; 340-353; 380-390 AND 422-437;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Fetal brain cortex.
8.

"Highly acidic proteins from human brain: purification and properties of Glu-50 protein."
Nomata Y. , Watanabe T. , Wada H.
J. Biochem.93:825-831(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 468-473
tissue: Brain.
9.

"PKN associates and phosphorylates the head-rod domain of neurofilament protein."
Mukai H. , Toshimori M. , Shibata H. , Kitagawa M. , Shimakawa M. , Miyahara M. , Sunakawa H. , Ono Y.
J. Biol. Chem.271:9816-9822(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKN1
10.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
12.

"A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene."
Mersiyanova I.V. , Perepelov A.V. , Polyakov A.V. , Sitnikov V.F. , Dadali E.L. , Oparin R.B. , Petrin A.N. , Evgrafov O.V.
Am. J. Hum. Genet.67:37-46(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT2E PRO-332
13.

"Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E."
De Jonghe P. , Mersivanova I. , Nelis E. , Del Favero J. , Martin J.-J. , Van Broeckhoven C. , Evgrafov O. , Timmerman V.
Ann. Neurol.49:245-249(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT2E ARG-8
14.

"A novel NF-L mutation Pro22Ser is associated with CMT2 in a large Slovenian family."
Georgiou D.-M. , Zidar J. , Korosec M. , Middleton L.T. , Kyriakides T. , Christodoulou K.
Neurogenetics4:93-96(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT2E SER-22
15.

"Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease."
Jordanova A. , De Jonghe P. , Boerkoel C.F. , Takashima H. , De Vriendt E. , Ceuterick C. , Martin J.-J. , Butler I.J. , Mancias P. , Papasozomenos S.C. , Terespolsky D. , Potocki L. , Brown C.W. , Shy M. , Rita D.A. , Tournev I. , Kremensky I. , Lupski J.R. , more...
Brain126:590-597(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMT1F ARG-8; LEU-8; GLN-8; LYS-90; SER-98 AND GLU-527 DEL;VARIANTS LYS-7 AND ASN-468
16.

"Mutational analysis of PMP22, MPZ, GJB1, EGR2 and NEFL in Korean Charcot-Marie-Tooth neuropathy patients."
Choi B.-O. , Lee M.S. , Shin S.H. , Hwang J.H. , Choi K.-G. , Kim W.-K. , Sunwoo I.N. , Kim N.K. , Chung K.W.
Hum. Mutat.24:185-186(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT2E PRO-336;VARIANT CMT1F LYS-396
17.

"The novel neurofilament light (NEFL) mutation Glu397Lys is associated with a clinically and morphologically heterogeneous type of Charcot-Marie-Tooth neuropathy."
Zuechner S. , Vorgerd M. , Sindern E. , Schroeder J.M.
Neuromuscul. Disord.14:147-157(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT1F LYS-396
18.

"The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan."
Lin K.P. , Soong B.W. , Yang C.C. , Huang L.W. , Chang M.H. , Lee I.H. , Antonellis A. , Lee Y.C.
PLoS ONE6:E29393-E29393(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMT2E ARG-8; SER-22 AND LYS-396

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