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Index > Protein center > TACR1(Gene name) > Human
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  • TACR1 (Gene name),
  • Substance-P receptor (Protein name ),  NK1R_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TACR1(NK1R;TAC1R);
    Protein name:
    Substance-P receptor(SPR);
    Alternative:
    Tachykinin receptor 1;NK-1 receptor(NK-1R);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ARRB1.
    Function:
    This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    407
    Sequence:
    50:
    MDNVLPVDSD | LSPNISTNTS | EPNQFVQPAW | QIVLWAAAYT | VIVVTSVVGN | 
    100:
    VVVMWIILAH | KRMRTVTNYF | LVNLAFAEAS | MAAFNTVVNF | TYAVHNEWYY | 
    150:
    GLFYCKFHNF | FPIAAVFASI | YSMTAVAFDR | YMAIIHPLQP | RLSATATKVV | 
    200:
    ICVIWVLALL | LAFPQGYYST | TETMPSRVVC | MIEWPEHPNK | IYEKVYHICV | 
    250:
    TVLIYFLPLL | VIGYAYTVVG | ITLWASEIPG | DSSDRYHEQV | SAKRKVVKMM | 
    300:
    IVVVCTFAIC | WLPFHIFFLL | PYINPDLYLK | KFIQQVYLAI | MWLAMSSTMY | 
    350:
    NPIIYCCLND | RFRLGFKHAF | RCCPFISAGD | YEGLEMKSTR | YLQTQGSVYK | 
    400:
    VSRLETTIST | VVGAHEEEPE | DGPKATPSSL | DLTSNCSSRS | DSKTMTESFS | 
    407:
    FSSNVLS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    SMR:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human SPR
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    E0392h
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    ELISA Kit for Human SPR
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    E0392m
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    96T
    ELISA Kit for Human SPR
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    E0392r
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    ELISA Kit for Human SPR
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    E0392d
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    Packing:
    96T
    CLIA Kit for Human SPR
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    U0392m
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    Packing:
    96T
    CLIA Kit for Human SPR
    Cat.:
    U0392h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human SPR
    Cat.:
    U0392r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SPR
    Cat.:
    U0392d
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human SPR
    Polyclonal Antibody for Human SPR
    Cat.:
    P0392Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SPR
    Cat.:
    P0392Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SPR
    Cat.:
    P0392Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SPR
    Monoclonal Antibody for Human SPR
    Monoclonal Antibody for Human SPR
    Monoclonal Antibody for Human SPR
    Protein for Human SPR
    Protein for Human SPR
    Protein for Human SPR
    Protein for Human SPR

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    References
    1. 1.
      "Molecular cloning, structural characterization and functional expression of the human substance P receptor."
      Takeda Y. , Chou K.B. , Takeda J. , Sachais B.S. , Krause J.E.
      Biochem. Biophys. Res. Commun.179:1232-1240(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Isolation and characterisation of the human lung NK-1 receptor cDNA."
      Hopkins B. , Powell S.J. , Danks P. , Briggs I. , Graham A.
      Biochem. Biophys. Res. Commun.180:1110-1117(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lung.
    3. 3.
      "Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones."
      Gerard N.P. , Garraway L.A. , Eddy R.L. Jr. , Shows T.B. , Iijima H. , Paquet J.L. , Gerard C.
      Biochemistry30:10640-10646(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "The primary structure and gene organization of human substance P and neuromedin K receptors."
      Takahashi K. , Tanaka A. , Hara M. , Nakanishi S.
      Eur. J. Biochem.204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
      tissue: Placenta.
    5. 5.
      "Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor."
      Fong T.M. , Anderson S.A. , Yu H. , Huang R.-R.C. , Strader C.D.
      Mol. Pharmacol.41:24-30(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    6. 6.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    8. 8.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    11. 11.
      "The human tachykinin NK1 (short form) and tachykinin NK4 receptor: a reappraisal."
      Page N.M. , Bell N.J.
      Eur. J. Pharmacol.437:27-30(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF DETECTION OF ISOFORM 2
    12. 12.
      "Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345."
      Fong T.M. , Cascieri M.A. , Yu H. , Bansai A. , Swain C. , Strader C.D.
      Nature362:350-353(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BINDING TO ANTAGONIST CP 96345
    13. 13.
      "NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."
      Gayen A. , Goswami S.K. , Mukhopadhyay C.
      Biochim. Biophys. Acta1808:127-139(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-364;DISULFIDE BOND
    14. 14.
      "Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant."
      Randolph G.P. , Simon J.S. , Arreaza M.G. , Qiu P. , Lachowicz J.E. , Duffy R.A.
      Pharmacogenomics J.4:394-402(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-192;CHARACTERIZATION OF VARIANT HIS-192
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