Gene name:
TACR3 (NK3R;TAC3R) ;
Protein name:
Neuromedin-K receptor (NKR) ;
Alternative:
Neurokinin B receptor ;NK-3 receptor (NK-3R) ;Tachykinin receptor 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MATLPAAETW | IDGGGGVGAD | AVNLTASLAA | GAATGAVETG | WLQLLDQAGN |
100:
LSSSPSALGL | PVASPAPSQP | WANLTNQFVQ | PSWRIALWSL | AYGVVVAVAV |
150:
LGNLIVIWII | LAHKRMRTVT | NYFLVNLAFS | DASMAAFNTL | VNFIYALHSE |
200:
WYFGANYCRF | QNFFPITAVF | ASIYSMTAIA | VDRYMAIIDP | LKPRLSATAT |
250:
KIVIGSIWIL | AFLLAFPQCL | YSKTKVMPGR | TLCFVQWPEG | PKQHFTYHII |
300:
VIILVYCFPL | LIMGITYTIV | GITLWGGEIP | GDTCDKYHEQ | LKAKRKVVKM |
350:
MIIVVMTFAI | CWLPYHIYFI | LTAIYQQLNR | WKYIQQVYLA | SFWLAMSSTM |
400:
YNPIIYCCLN | KRFRAGFKRA | FRWCPFIKVS | SYDELELKTT | RFHPNRQSSM |
450:
YTVTRMESMT | VVFDPNDADT | TRSSRKKRAT | PRDPSFNGCS | RRNSKSASAT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
Polyclonal Antibody for Human NKR
Polyclonal Antibody for Human NKR
Polyclonal Antibody for Human NKR
Polyclonal Antibody for Human NKR
Monoclonal Antibody for Human NKR
Monoclonal Antibody for Human NKR
Monoclonal Antibody for Human NKR
Monoclonal Antibody for Human NKR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
4.
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A.
,
Aronstam R.S.
,
Sharma S.V.
Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
"TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction."
Topaloglu A.K.
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Reimann F.
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Guclu M.
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Yalin A.S.
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Kotan L.D.
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Semple R.K.
Nat. Genet.41:354-358(2009)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HH11 ASP-93 AND SER-353;CHARACTERIZATION OF VARIANTS HH11 ASP-93 AND SER-353
7.
"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Miraoui H.
,
Dwyer A.A.
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Sykiotis G.P.
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Plummer L.
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Chung W.
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Feng B.
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Beenken A.
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Clarke J.
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Pers T.H.
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Dworzynski P.
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Keefe K.
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Niedziela M.
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Raivio T.
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Crowley W.F. Jr.
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Seminara S.B.
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Quinton R.
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Hughes V.A.
,
Kumanov P.
,
Young J.
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Yialamas M.A.
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Hall J.E.
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Van Vliet G.
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Chanoine J.P.
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Rubenstein J.
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Mohammadi M.
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Tsai P.S.
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Sidis Y.
,
Lage K.
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Pitteloud N.
more...
Am. J. Hum. Genet.92:725-743(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT HH11 GLN-364;VARIANTS ARG-286 AND THR-449