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Index > Protein center > TACR3(Gene name) > Human
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  • TACR3 (Gene name),
  • Neuromedin-K receptor (Protein name ),  NK3R_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TACR3(NK3R;TAC3R);
    Protein name:
    Neuromedin-K receptor(NKR);
    Alternative:
    Neurokinin B receptor;NK-3 receptor(NK-3R);Tachykinin receptor 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    MATLPAAETW | IDGGGGVGAD | AVNLTASLAA | GAATGAVETG | WLQLLDQAGN | 
    100:
    LSSSPSALGL | PVASPAPSQP | WANLTNQFVQ | PSWRIALWSL | AYGVVVAVAV | 
    150:
    LGNLIVIWII | LAHKRMRTVT | NYFLVNLAFS | DASMAAFNTL | VNFIYALHSE | 
    200:
    WYFGANYCRF | QNFFPITAVF | ASIYSMTAIA | VDRYMAIIDP | LKPRLSATAT | 
    250:
    KIVIGSIWIL | AFLLAFPQCL | YSKTKVMPGR | TLCFVQWPEG | PKQHFTYHII | 
    300:
    VIILVYCFPL | LIMGITYTIV | GITLWGGEIP | GDTCDKYHEQ | LKAKRKVVKM | 
    350:
    MIIVVMTFAI | CWLPYHIYFI | LTAIYQQLNR | WKYIQQVYLA | SFWLAMSSTM | 
    400:
    YNPIIYCCLN | KRFRAGFKRA | FRWCPFIKVS | SYDELELKTT | RFHPNRQSSM | 
    450:
    YTVTRMESMT | VVFDPNDADT | TRSSRKKRAT | PRDPSFNGCS | RRNSKSASAT | 
    465:
    SSFISSPYTS | VDEYS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human NKR
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    ELISA Kit for Human NKR
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    ELISA Kit for Human NKR
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    Packing:
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    ELISA Kit for Human NKR
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    CLIA Kit for Human NKR
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    CLIA Kit for Human NKR
    MSDS:
    Please sign in first.
    CLIA Kit for Human NKR
    Cat.:
    U14992h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NKR
    Cat.:
    U14992m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NKR
    Polyclonal Antibody for Human NKR
    Polyclonal Antibody for Human NKR
    Polyclonal Antibody for Human NKR
    Monoclonal Antibody for Human NKR
    Monoclonal Antibody for Human NKR
    Monoclonal Antibody for Human NKR
    Monoclonal Antibody for Human NKR
    Protein for Human NKR
    Protein for Human NKR
    Protein for Human NKR
    Protein for Human NKR

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    References
    1. 1.
      "cDNA sequence and heterologous expression of the human neurokinin-3 receptor."
      Huang R.-R.C. , Cheung A.H. , Mazina K.E. , Strader C.D. , Fong T.M.
      Biochem. Biophys. Res. Commun.184:966-972(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Molecular characterisation, expression and localisation of human neurokinin-3 receptor."
      Buell G. , Schulz M.F. , Arkinstall S.J. , Maury K. , Missotten M. , Adami N. , Talabot F. , Kawashima E.
      FEBS Lett.299:90-95(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The primary structure and gene organization of human substance P and neuromedin K receptors."
      Takahashi K. , Tanaka A. , Hara M. , Nakanishi S.
      Eur. J. Biochem.204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction."
      Topaloglu A.K. , Reimann F. , Guclu M. , Yalin A.S. , Kotan L.D. , Porter K.M. , Serin A. , Mungan N.O. , Cook J.R. , Ozbek M.N. , Imamoglu S. , Akalin N.S. , Yuksel B. , O'Rahilly S. , Semple R.K.
      Nat. Genet.41:354-358(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH11 ASP-93 AND SER-353;CHARACTERIZATION OF VARIANTS HH11 ASP-93 AND SER-353
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH11 GLN-364;VARIANTS ARG-286 AND THR-449
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