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Index > Protein center > NLRC4(Gene name) > Human
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  • NLRC4 (Gene name),
  • NLR family CARD domain-containing protein 4 (Protein name ),  NLRC4_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
  • |
  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    NLRC4(UNQ6189/PRO20215;CARD12;CLAN;CLAN1;IPAF);
    Protein name:
    NLR family CARD domain-containing protein 4;
    Alternative:
    Caspase recruitment domain-containing protein 12;CARD, LRR, and NACHT-containing protein(Clan protein);Ice protease-activating factor(Ipaf);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.
    Function:
    Plays a role in the promotion of apoptosis.
    Subcellular Location:
    Cytoplasm Cytoplasmic filaments.
    Protein Attributes:
    Sequence length:
    1024
    Sequence:
    50:
    MNFIKDNSRA | LIQRMGMTVI | KQITDDLFVW | NVLNREEVNI | ICCEKVEQDA | 
    100:
    ARGIIHMILK | KGSESCNLFL | KSLKEWNYPL | FQDLNGQSLF | HQTSEGDLDD | 
    150:
    LAQDLKDLYH | TPSFLNFYPL | GEDIDIIFNL | KSTFTEPVLW | RKDQHHHRVE | 
    200:
    QLTLNGLLQA | LQSPCIIEGE | SGKGKSTLLQ | RIAMLWGSGK | CKALTKFKFV | 
    250:
    FFLRLSRAQG | GLFETLCDQL | LDIPGTIRKQ | TFMAMLLKLR | QRVLFLLDGY | 
    300:
    NEFKPQNCPE | IEALIKENHR | FKNMVIVTTT | TECLRHIRQF | GALTAEVGDM | 
    350:
    TEDSAQALIR | EVLIKELAEG | LLLQIQKSRC | LRNLMKTPLF | VVITCAIQMG | 
    400:
    ESEFHSHTQT | TLFHTFYDLL | IQKNKHKHKG | VAASDFIRSL | DHCGDLALEG | 
    450:
    VFSHKFDFEL | QDVSSVNEDV | LLTTGLLCKY | TAQRFKPKYK | FFHKSFQEYT | 
    500:
    AGRRLSSLLT | SHEPEEVTKG | NGYLQKMVSI | SDITSTYSSL | LRYTCGSSVE | 
    550:
    ATRAVMKHLA | AVYQHGCLLG | LSIAKRPLWR | QESLQSVKNT | TEQEILKAIN | 
    600:
    INSFVECGIH | LYQESTSKSA | LSQEFEAFFQ | GKSLYINSGN | IPDYLFDFFE | 
    650:
    HLPNCASALD | FIKLDFYGGA | MASWEKAAED | TGGIHMEEAP | ETYIPSRAVS | 
    700:
    LFFNWKQEFR | TLEVTLRDFS | KLNKQDIRYL | GKIFSSATSL | RLQIKRCAGV | 
    750:
    AGSLSLVLST | CKNIYSLMVE | ASPLTIEDER | HITSVTNLKT | LSIHDLQNQR | 
    800:
    LPGGLTDSLG | NLKNLTKLIM | DNIKMNEEDA | IKLAEGLKNL | KKMCLFHLTH | 
    850:
    LSDIGEGMDY | IVKSLSSEPC | DLEEIQLVSC | CLSANAVKIL | AQNLHNLVKL | 
    900:
    SILDLSENYL | EKDGNEALHE | LIDRMNVLEQ | LTALMLPWGC | DVQGSLSSLL | 
    950:
    KHLEEVPQLV | KLGLKNWRLT | DTEIRILGAF | FGKNPLKNFQ | QLNLAGNRVS | 
    1000:
    SDGWLAFMGV | FENLKQLVFF | DFSTKEFLPD | PALVRKLSQV | LSKLTFLQEA | 
    1024:
    RLVGWQFDDD | DLSVITGAFK | LVTA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human NLR family CARD domain-containing protein 4
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    E1535h
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    96T
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    ELISA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    E1535b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    E1535m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    E1535r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    U1535h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    U1535b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    U1535r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NLR family CARD domain-containing protein 4
    Cat.:
    U1535m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human NLR family CARD domain-containing protein 4
    Cat.:
    P1535Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NLR family CARD domain-containing protein 4
    Polyclonal Antibody for Human NLR family CARD domain-containing protein 4
    Cat.:
    P1535Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NLR family CARD domain-containing protein 4
    Cat.:
    P1535Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NLR family CARD domain-containing protein 4
    Monoclonal Antibody for Human NLR family CARD domain-containing protein 4
    Monoclonal Antibody for Human NLR family CARD domain-containing protein 4
    Monoclonal Antibody for Human NLR family CARD domain-containing protein 4
    Protein for Human NLR family CARD domain-containing protein 4
    Protein for Human NLR family CARD domain-containing protein 4
    Protein for Human NLR family CARD domain-containing protein 4
    Protein for Human NLR family CARD domain-containing protein 4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4)
      tissue: Lung.
    3. 3.
      "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1."
      Poyet J.-L. , Srinivasula S.M. , Tnani M. , Razmara M. , Fernandes-Alnemri T. , Alnemri E.S.
      J. Biol. Chem.276:28309-28313(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
      tissue: Leukocyte.
    4. 4.
      "Differential expression of the caspase recruitment domain protein 12 (CARD12) during monocytic differentiation."
      Gingras M. , Qiu J. , Margolin J.F.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Thymus.
      tissue: Uterus.
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
      tissue: Testis.
    10. 10.
      The European IMAGE consortium
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 586-1024 (ISOFORM 1)
    11. 11.
      "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses."
      Damiano J.S. , Oliveira V. , Welsh K. , Reed J.C.
      Biochem. J.381:213-219(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF2AK2
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