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Index > Protein center > NOG(Gene name) > Human
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  • NOG (Gene name),
  • Noggin (Protein name ),  NOGG_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    NOG;
    Protein name:
    Noggin;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    232
    Sequence:
    50:
    MERCPSLGVT | LYALVVVLGL | RATPAGGQHY | LHIRPAPSDN | LPLVDLIEHP | 
    100:
    DPIFDPKEKD | LNETLLRSLL | GGHYDPGFMA | TSPPEDRPGG | GGGAAGGAED | 
    150:
    LAELDQLLRQ | RPSGAMPSEI | KGLEFSEGLA | QGKKQRLSKK | LRRKLQMWLW | 
    200:
    SQTFCPVLYA | WNDLGSRFWP | RYVKVGSCFS | KRSCSVPEGM | VCKPSKSVHL | 
    232:
    TVLRWRCQRR | GGQRCGWIPI | QYPIISECKC | SC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Noggin
    Cat.:
    E0796h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Noggin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Noggin
    Cat.:
    E0796m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Noggin
    Cat.:
    E0796c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Noggin
    Cat.:
    U0796c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Noggin
    Cat.:
    U0796m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Noggin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Noggin
    Cat.:
    U0796h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Noggin
    Polyclonal Antibody for Human Noggin
    Cat.:
    P0796Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Noggin
    Cat.:
    P0796Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Noggin
    Monoclonal Antibody for Human Noggin
    Monoclonal Antibody for Human Noggin
    Monoclonal Antibody for Human Noggin
    Monoclonal Antibody for Human Noggin
    Protein for Human Noggin
    Protein for Human Noggin
    Protein for Human Noggin
    Protein for Human Noggin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
      tissue: Temporal cortex.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    3. 3.
      "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."
      Groppe J. , Greenwald J. , Wiater E. , Rodriguez-Leon J. , Economides A.N. , Kwiatkowski W. , Affolter M. , Vale W.W. , Belmonte J.C. , Choe S.
      Nature420:636-642(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 28-232 IN COMPLEX WITH BMP7;FUNCTION;SUBUNIT;DISULFIDE BONDS
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SYM1A ARG-35; CYS-189; ASN-220; CYS-222; ASP-222 AND LEU-223;VARIANT SYNS1 GLY-217
    5. 5.
      "Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."
      Takahashi T. , Takahashi I. , Komatsu M. , Sawaishi Y. , Higashi K. , Nishimura G. , Saito H. , Takada G.
      Clin. Genet.60:447-451(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1A TYR-184
    6. 6.
      "Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."
      Dixon M.E. , Armstrong P. , Stevens D.B. , Bamshad M.
      Genet. Med.3:349-353(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TCC ARG-35; LEU-204 AND CYS-222
    7. 7.
      "Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin."
      Brown D.J. , Kim T.B. , Petty E.M. , Downs C.A. , Martin D.M. , Strouse P.J. , Moroi S.E. , Milunsky J.M. , Lesperance M.M.
      Am. J. Hum. Genet.71:618-624(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SABTS
    8. 8.
      "Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."
      Mangino M. , Flex E. , Digilio M.C. , Giannotti A. , Dallapiccola B.
      Hum. Mutat.19:308-308(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1A SER-35
    9. 9.
      "The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene."
      van den Ende J.J. , Mattelaer P. , Declau F. , Vanhoenacker F. , Claes J. , Van Hul E. , Baten E.
      Clin. Dysmorphol.14:73-80(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYM1A CYS-205
    10. 10.
      "A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN."
      Lehmann K. , Seemann P. , Silan F. , Goecke T.O. , Irgang S. , Kjaer K.W. , Kjaergaard S. , Mahoney M.J. , Morlot S. , Reissner C. , Kerr B. , Wilkie A.O.M. , Mundlos S.
      Am. J. Hum. Genet.81:388-396(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDB2 ALA-35; SER-35; PRO-36; LYS-48; GLY-167 AND SER-187
    11. 11.
      "Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."
      Rudnik-Schoneborn S. , Takahashi T. , Busse S. , Schmidt T. , Senderek J. , Eggermann T. , Zerres K.
      Am. J. Med. Genet. A152:1540-1544(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYNS1 TRP-232
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