Nos1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNos1 ELISA Kit for Rat(Rattus norvegicus)

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Nos1 (Gene name),

Nitric oxide synthase, brain (Protein name ), NOS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nos1(Bnos);

Protein name:

Nitric oxide synthase, brain;

Alternative:

Constitutive NOS;BNOS;NOS type I;NC-NOS;Peptidyl-cysteine S-nitrosylase NOS1;Neuronal NOS(N-NOS;nNOS);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON (By similarity). Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location. Interacts with HTR4 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with VAC14.

Function:

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

Subcellular Location:

Cell membrane sarcolemma Peripheral membrane protein Cell projection dendritic spine In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines.

Protein Attributes:

Sequence length:

1429

Sequence:

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1400:

1429:

TYEVTNRLRS | ESIAFIEESK | KDADEVFSS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.10573

STRING:

10116.ENSRNOP00000062735

String:

P29476

Pfam:

PF00667

SMR:

P29476

KEGG:

rno:24598

Uniprot:

P29476

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ELISA Kit for Rat Nitric oxide synthase, brain

Cat.:

E0628r

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96T

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ELISA Kit for Rat Nitric oxide synthase, brain

Cat.:

E0628h

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96T

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ELISA Kit for Rat Nitric oxide synthase, brain

Cat.:

E0628m

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96T

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ELISA Kit for Rat Nitric oxide synthase, brain

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CLIA Kit for Rat Nitric oxide synthase, brain

MSDS:

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CLIA Kit for Rat Nitric oxide synthase, brain

Cat.:

U0628h

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CLIA Kit for Rat Nitric oxide synthase, brain

Cat.:

U0628r

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96T

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CLIA Kit for Rat Nitric oxide synthase, brain

Cat.:

U0628m

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96T

Polyclonal Antibody for Rat Nitric oxide synthase, brain

Cat.:

P0628Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Nitric oxide synthase, brain

Cat.:

P0628Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Nitric oxide synthase, brain

Cat.:

P0628Rb-r

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40ug/0.2ml

Monoclonal Antibody for Rat Nitric oxide synthase, brain

Protein for Rat Nitric oxide synthase, brain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase."
Bredt D.S. , Hwang P.M. , Glatt C.L. , Lowenstein C. , Reed R.R. , Snyder S.H.
Nature351:714-718(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Brain.
2.

"Cloning of a novel neuronal nitric oxide synthase expressed in penis and lower urinary tract."
Magee T. , Fuentes A.M. , Garban H. , Rajavashisth T. , Marquez D. , Rodriguez J.A. , Rajfer J. , Gonzalez-Cadavid N.F.
Biochem. Biophys. Res. Commun.226:145-151(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PNNOS)
strain: Fischer 344.
tissue: Penis.
3.

"Nitric oxide synthase from rat colorectum: purification, peptide sequencing, partial PCR cloning, and immunohistochemistry."
Seo H.G. , Tatsumi H. , Fujii J. , Nishikawa A. , Suzuki K. , Kangawa K. , Taniguchi N.
J. Biochem.115:602-607(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 119-129; 132-142; 144-156; 189-200; 264-276; 305-310; 360-369; 376-379; 381-385; 387-396; 779-785; 953-963 AND 1131-1139;TISSUE SPECIFICITY
tissue: Colon.
4.

"The identification of the pterin-binding domain in the nitric oxide synthase's sequence."
Uvarov V.Y. , Lyashenko A.A.
Biochem. Biophys. Res. Commun.206:736-741(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF TETRAHYDROBIOPTERIN-BINDING DOMAIN
5.

"Unusual role of Tyr588 of neuronal nitric oxide synthase in controlling substrate specificity and electron transfer."
Sato Y. , Sagami I. , Matsui T. , Shimizu T.
Biochem. Biophys. Res. Commun.281:621-626(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-588
6.

"Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON."
Fang M. , Jaffrey S.R. , Sawa A. , Ye K. , Luo X. , Snyder S.H.
Neuron28:183-193(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAPON AND RASD1
7.

"Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON."
Jaffrey S.R. , Benfenati F. , Snowman A.M. , Czernik A.J. , Snyder S.H.
Proc. Natl. Acad. Sci. U.S.A.99:3199-3204(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAPON AND SYN1
8.

"NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity."
Saitoh F. , Tian Q.B. , Okano A. , Sakagami H. , Kondo H. , Suzuki T.
J. Biol. Chem.279:29461-29468(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZDHHC23
9.

"Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase."
Peng H.M. , Morishima Y. , Jenkins G.J. , Dunbar A.Y. , Lau M. , Patterson C. , Pratt W.B. , Osawa Y.
J. Biol. Chem.279:52970-52977(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
10.

"Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity."
Dreyer J. , Schleicher M. , Tappe A. , Schilling K. , Kuner T. , Kusumawidijaja G. , Mueller-Esterl W. , Oess S. , Kuner R.
J. Neurosci.24:10454-10465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSIP;ENZYME REGULATION;SUBCELLULAR LOCATION
11.

"Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif."
Lemaire J.F. , McPherson P.S.
FEBS Lett.580:6948-6954(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VAC14;DOMAIN
12.

"Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."
Akama K.T. , Thompson L.I. , Milner T.A. , McEwen B.S.
J. Biol. Chem.288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG4
13.

"Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex."
Hillier B.J. , Christopherson K.S. , Prehoda K.E. , Bredt D.S. , Lim W.A.
Science284:812-815(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 14-125
14.

"Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with nadph-cytochrome p450 oxidoreductase."
Zhang J. , Martasek P. , Paschke R. , Shea T. , Masters B.S.S. , Kim J.-J.P.
J. Biol. Chem.276:37506-37513(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 963-1397

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