Protein name:
Neurogenic locus notch homolog protein 1 (Notch 1;hN1) ;
Alternative:
Translocation-associated notch protein TAN-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.
Subcellular Location:
Notch 1 intracellular domain
Nucleus
Following proteolytical processing NICD is translocated to the nucleus.
Protein Attributes:
50:
MPPLLAPLLC | LALLPALAAR | GPRCSQPGET | CLNGGKCEAA | NGTEACVCGG |
100:
AFVGPRCQDP | NPCLSTPCKN | AGTCHVVDRR | GVADYACSCA | LGFSGPLCLT |
150:
PLDNACLTNP | CRNGGTCDLL | TLTEYKCRCP | PGWSGKSCQQ | ADPCASNPCA |
200:
NGGQCLPFEA | SYICHCPPSF | HGPTCRQDVN | ECGQKPGLCR | HGGTCHNEVG |
250:
SYRCVCRATH | TGPNCERPYV | PCSPSPCQNG | GTCRPTGDVT | HECACLPGFT |
300:
GQNCEENIDD | CPGNNCKNGG | ACVDGVNTYN | CRCPPEWTGQ | YCTEDVDECQ |
350:
LMPNACQNGG | TCHNTHGGYN | CVCVNGWTGE | DCSENIDDCA | SAACFHGATC |
400:
HDRVASFYCE | CPHGRTGLLC | HLNDACISNP | CNEGSNCDTN | PVNGKAICTC |
450:
PSGYTGPACS | QDVDECSLGA | NPCEHAGKCI | NTLGSFECQC | LQGYTGPRCE |
500:
IDVNECVSNP | CQNDATCLDQ | IGEFQCICMP | GYEGVHCEVN | TDECASSPCL |
550:
HNGRCLDKIN | EFQCECPTGF | TGHLCQYDVD | ECASTPCKNG | AKCLDGPNTY |
600:
TCVCTEGYTG | THCEVDIDEC | DPDPCHYGSC | KDGVATFTCL | CRPGYTGHHC |
650:
ETNINECSSQ | PCRHGGTCQD | RDNAYLCFCL | KGTTGPNCEI | NLDDCASSPC |
700:
DSGTCLDKID | GYECACEPGY | TGSMCNINID | ECAGNPCHNG | GTCEDGINGF |
750:
TCRCPEGYHD | PTCLSEVNEC | NSNPCVHGAC | RDSLNGYKCD | CDPGWSGTNC |
800:
DINNNECESN | PCVNGGTCKD | MTSGYVCTCR | EGFSGPNCQT | NINECASNPC |
850:
LNQGTCIDDV | AGYKCNCLLP | YTGATCEVVL | APCAPSPCRN | GGECRQSEDY |
900:
ESFSCVCPTG | WQGQTCEVDI | NECVLSPCRH | GASCQNTHGG | YRCHCQAGYS |
950:
GRNCETDIDD | CRPNPCHNGG | SCTDGINTAF | CDCLPGFRGT | FCEEDINECA |
1000:
SDPCRNGANC | TDCVDSYTCT | CPAGFSGIHC | ENNTPDCTES | SCFNGGTCVD |
1050:
GINSFTCLCP | PGFTGSYCQH | DVNECDSQPC | LHGGTCQDGC | GSYRCTCPQG |
1100:
YTGPNCQNLV | HWCDSSPCKN | GGKCWQTHTQ | YRCECPSGWT | GLYCDVPSVS |
1150:
CEVAAQRQGV | DVARLCQHGG | LCVDAGNTHH | CRCQAGYTGS | YCEDLVDECS |
1200:
PSPCQNGATC | TDYLGGYSCK | CVAGYHGVNC | SEEIDECLSH | PCQNGGTCLD |
1250:
LPNTYKCSCP | RGTQGVHCEI | NVDDCNPPVD | PVSRSPKCFN | NGTCVDQVGG |
1300:
YSCTCPPGFV | GERCEGDVNE | CLSNPCDARG | TQNCVQRVND | FHCECRAGHT |
1350:
GRRCESVING | CKGKPCKNGG | TCAVASNTAR | GFICKCPAGF | EGATCENDAR |
1400:
TCGSLRCLNG | GTCISGPRSP | TCLCLGPFTG | PECQFPASSP | CLGGNPCYNQ |
1450:
GTCEPTSESP | FYRCLCPAKF | NGLLCHILDY | SFGGGAGRDI | PPPLIEEACE |
1500:
LPECQEDAGN | KVCSLQCNNH | ACGWDGGDCS | LNFNDPWKNC | TQSLQCWKYF |
1550:
SDGHCDSQCN | SAGCLFDGFD | CQRAEGQCNP | LYDQYCKDHF | SDGHCDQGCN |
1600:
SAECEWDGLD | CAEHVPERLA | AGTLVVVVLM | PPEQLRNSSF | HFLRELSRVL |
1650:
HTNVVFKRDA | HGQQMIFPYY | GREEELRKHP | IKRAAEGWAA | PDALLGQVKA |
1700:
SLLPGGSEGG | RRRRELDPMD | VRGSIVYLEI | DNRQCVQASS | QCFQSATDVA |
1750:
AFLGALASLG | SLNIPYKIEA | VQSETVEPPP | PAQLHFMYVA | AAAFVLLFFV |
1800:
GCGVLLSRKR | RRQHGQLWFP | EGFKVSEASK | KKRREPLGED | SVGLKPLKNA |
1850:
SDGALMDDNQ | NEWGDEDLET | KKFRFEEPVV | LPDLDDQTDH | RQWTQQHLDA |
1900:
ADLRMSAMAP | TPPQGEVDAD | CMDVNVRGPD | GFTPLMIASC | SGGGLETGNS |
1950:
EEEEDAPAVI | SDFIYQGASL | HNQTDRTGET | ALHLAARYSR | SDAAKRLLEA |
2000:
SADANIQDNM | GRTPLHAAVS | ADAQGVFQIL | IRNRATDLDA | RMHDGTTPLI |
2050:
LAARLAVEGM | LEDLINSHAD | VNAVDDLGKS | ALHWAAAVNN | VDAAVVLLKN |
2100:
GANKDMQNNR | EETPLFLAAR | EGSYETAKVL | LDHFANRDIT | DHMDRLPRDI |
2150:
AQERMHHDIV | RLLDEYNLVR | SPQLHGAPLG | GTPTLSPPLC | SPNGYLGSLK |
2200:
PGVQGKKVRK | PSSKGLACGS | KEAKDLKARR | KKSQDGKGCL | LDSSGMLSPV |
2250:
DSLESPHGYL | SDVASPPLLP | SPFQQSPSVP | LNHLPGMPDT | HLGIGHLNVA |
2300:
AKPEMAALGG | GGRLAFETGP | PRLSHLPVAS | GTSTVLGSSS | GGALNFTVGG |
2350:
STSLNGQCEW | LSRLQSGMVP | NQYNPLRGSV | APGPLSTQAP | SLQHGMVGPL |
2400:
HSSLAASALS | QMMSYQGLPS | TRLATQPHLV | QTQQVQPQNL | QMQQQNLQPA |
2450:
NIQQQQSLQP | PPPPPQPHLG | VSSAASGHLG | RSFLSGEPSQ | ADVQPLGPSS |
2500:
LAVHTILPQE | SPALPTSLPS | SLVPPVTAAQ | FLTPPSQHSY | SSPVDNTPSH |
2550:
QLQVPEHPFL | TPSPESPDQW | SSSSPHSNVS | DWSEGVSSPP | TSMQSQIARI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Notch 1
ELISA Kit for Human Notch 1
ELISA Kit for Human Notch 1
CLIA Kit for Human Notch 1
CLIA Kit for Human Notch 1
CLIA Kit for Human Notch 1
Polyclonal Antibody for Human Notch 1
Polyclonal Antibody for Human Notch 1
Polyclonal Antibody for Human Notch 1
Monoclonal Antibody for Human Notch 1
Monoclonal Antibody for Human Notch 1
Monoclonal Antibody for Human Notch 1
Protein for Human Notch 1
Protein for Human Notch 1
Protein for Human Notch 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-2555
tissue :
Aortic endothelium .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1947-1962;INTERACTION WITH HIF1AN;HYDROXYLATION AT ASN-1955;IDENTIFICATION BY MASS SPECTROMETRY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF LIGANDS
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DTX1
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNW1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAML1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAML2 AND MAML3
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY ITCH
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNAI1 AND MDM2A
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AAK1
16.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SGK1 AND FBXW7
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNW1
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-232; THR-1402 AND THR-1725;PROTEOLYTIC PROCESSING
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1446-1480 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BONDS
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 411-526
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1872-2114
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 1872-2126 IN COMPLEX WITH RBPSUH AND MAML1
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN AOVD1