NOTCH3 ELISA Kit for Human(Homo sapiens) | EIAab.comNOTCH3 ELISA Kit for Human(Homo sapiens)

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NOTCH3 (Gene name),

Neurogenic locus notch homolog protein 3 (Protein name ), NOTC3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NOTCH3;

Protein name:

Neurogenic locus notch homolog protein 3(Notch 3);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1.

Function:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Subcellular Location:

Notch 3 intracellular domain Nucleus Following proteolytical processing NICD is translocated to the nucleus.

Protein Attributes:

Sequence length:

2321

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2321:

AQAQTQLGPQ | PEVTPKRQVL | A

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9UM47

MIM:

125310

UniGene:

Hs.8546

Pfam:

PF12796

STRING:

9606.ENSP00000263388

SMR:

Q9UM47

KEGG:

hsa:4854

Uniprot:

Q9UM47

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ELISA Kit for Human Notch 3

Cat.:

E3908m

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Notch 3

Cat.:

E3908r

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MSDS:

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Packing:

96T

ELISA Kit for Human Notch 3

Cat.:

E3908h

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Manual:

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Packing:

96T

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CLIA Kit for Human Notch 3

Cat.:

U3908h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Notch 3

Cat.:

U3908m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Notch 3

Cat.:

U3908r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Notch 3

Cat.:

P3908Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Notch 3

Cat.:

P3908Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Notch 3

Protein for Human Notch 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia."
Joutel A. , Corpechot C. , Ducros A. , Vahedi K. , Chabriat H. , Mouton P. , Alamowitch S. , Domenga V. , Cecillion M. , Marechal E. , Maciazek J. , Vayssiere C. , Cruaud C. , Cabanis E.-A. , Ruchoux M.M. , Weissenbach J. , Bach J.-F. , Bousser M.-G. , more...
Nature383:707-710(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-2223
2.

Gunel M. , Artavanis-Tsakonas S.
Submitted (1998-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Human ligands of the Notch receptor."
Gray G.E. , Mann R.S. , Mitsiadis E. , Henrique D. , Carcangiu M.-L. , Banks A. , Leiman J. , Ward D. , Ish-Horowitz D. , Artavanis-Tsakonas S.
Am. J. Pathol.154:785-794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGANDS
5.

"MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."
Wu L. , Aster J.C. , Blacklow S.C. , Lake R. , Artavanis-Tsakonas S. , Griffin J.D.
Nat. Genet.26:484-489(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML1
6.

"Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."
Wu L. , Sun T. , Kobayashi K. , Gao P. , Griffin J.D.
Mol. Cell. Biol.22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAML2 AND MAML3
7.

"Conserved signal peptide of Notch3 inhibits interaction with proteasome."
Zhang Y. , Jia L. , Lee S.J. , Wang M.M.
Biochem. Biophys. Res. Commun.355:245-251(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMA1
8.

"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L. , McDonough M.A. , Hewitson K.S. , Coles C. , Mecinovic J. , Edelmann M. , Cook K.M. , Cockman M.E. , Lancaster D.E. , Kessler B.M. , Oldham N.J. , Ratcliffe P.J. , Schofield C.J.
J. Biol. Chem.282:24027-24038(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIF1AN
9.

"Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways."
Zheng X. , Linke S. , Dias J.M. , Zheng X. , Gradin K. , Wallis T.P. , Hamilton B.R. , Gustafsson M. , Ruas J.L. , Wilkins S. , Bilton R.L. , Brismar K. , Whitelaw M.L. , Pereira T. , Gorman J.J. , Ericson J. , Peet D.J. , Lendahl U. , more...
Proc. Natl. Acad. Sci. U.S.A.105:3368-3373(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION BY HIF1AN
10.

"Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients."
Joutel A. , Vahedi K. , Corpechot C. , Troesch A. , Chabriat H. , Vayssiere C. , Cruaud C. , Maciazek J. , Weissenbach J. , Bousser M.-G. , Bach J.-F. , Tournier-Lasserve E.
Lancet350:1511-1515(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL TYR-49; CYS-71; CYS-90; CYS-110; CYS-133; CYS-141; ARG-146; CYS-153; CYS-169; CYS-171; CYS-182; ARG-185; SER-212; GLY-222; TYR-224; CYS-258; TYR-542; CYS-558; CYS-578; CYS-728; CYS-985; CYS-1006; CYS-1031; CYS-1231 AND ARG-1261;VARIANTS ARG-170; LEU-496; GLN-1133; MET-1183 AND VAL-2223
11.

"Quantitative MRI in CADASIL: correlation with disability and cognitive performance."
Dichgans M. , Filippi M. , Bruening R. , Iannucci G. , Berchtenbreiter C. , Minicucci L. , Uttner I. , Crispin A. , Ludwig H. , Gasser T. , Yousry T.A.
Neurology52:1361-1367(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL CYS-90; PHE-117; CYS-133; CYS-141; CYS-169; TYR-174; CYS-182 AND ARG-183
12.

"Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients. Dutch CADASIL Research Group."
Dutch CADASIL research group , Lesnik Oberstein S.A.J. , Ferrari M.D. , Bakker E. , van Gestel J. , Kneppers A.L.J. , Frants R.R. , Breuning M.H. , Haan J.
Neurology52:1913-1915(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL CYS-133; CYS-141; CYS-153; CYS-182; CYS-207; CYS-544 AND ARG-1015
13.

"Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains."
Dichgans M. , Ludwig H. , Mueller-Hoecker J. , Messerschmidt A. , Gasser T.
Eur. J. Hum. Genet.8:280-285(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL 80-ASP--SER-84 DEL; CYS-90; PHE-93; CYS-110; PHE-117; PHE-123; CYS-133; CYS-141; SER-144; TYR-144; CYS-150; 153-ARG--CYS-155 DEL; CYS-153; CYS-169; TYR-174; CYS-182; ARG-183; SER-183; ARG-185 AND PHE-194
14.

"Identification of a novel mutation C144F in the Notch3 gene in an Australian CADASIL pedigree."
Grigg R. , Lea R. , Sullivan A.A. , Curtain R. , MacMillian J. , Griffiths L.
Hum. Mutat.16:449-450(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL PHE-144
15.

"Evaluation of DHPLC analysis in mutational scanning of Notch3, a gene with a high G-C content."
Escary J.-L. , Cecillon M. , Maciazek J. , Lathrop M. , Tournier-Lasserve E. , Joutel A.
Hum. Mutat.16:518-526(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL TYR-49; CYS-54; CYS-90; CYS-110; 114-GLY--PRO-120 DEL; TYR-123; CYS-133; CYS-141; ARG-146; CYS-153; SER-162; CYS-169; TYR-174; CYS-180; CYS-182; ARG-185; TYR-194; TYR-206; CYS-207; SER-212; GLY-222; TYR-224; CYS-258; TYR-542; CYS-558; CYS-578; CYS-607; CYS-728; CYS-984; CYS-985; CYS-1006; CYS-1031; CYS-1231 AND ARG-1261
16.

"Splice site mutation causing a seven amino acid Notch3 in-frame deletion in CADASIL."
Joutel A. , Chabriat H. , Vahedi K. , Domenga V. , Vayssiere C. , Ruchoux M.M. , Lucas C. , Leys D. , Bousser M.-G. , Tournier-Lasserve E.
Neurology54:1874-1875(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL 114-GLY--PRO-120 DEL
17.

"A novel mutation in the Notch3 gene in an Italian family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: genetic and magnetic resonance spectroscopic findings."
Oliveri R.L. , Muglia M. , De Stefano N. , Mazzei R. , Labate A. , Conforti F.L. , Patitucci A. , Gabriele A.L. , Tagarelli G. , Magariello A. , Zappia M. , Gambardella A. , Federico A. , Quattrone A.
Arch. Neurol.58:1418-1422(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL CYS-332
18.

"Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis."
Joutel A. , Favrole P. , Labauge P. , Chabriat H. , Lescoat C. , Andreux F. , Domenga V. , Cecillon M. , Vahedi K. , Ducros A. , Cave-Riant F. , Bousser M.G. , Tournier-Lasserve E.
Lancet358:2049-2051(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL CYS-110; CYS-133; TRP-134; CYS-141; CYS-153; CYS-182; GLY-185; CYS-207; SER-212; GLY-222; SER-428; CYS-558; CYS-985 AND CYS-1063
19.

"Reversible coma with raised intracranial pressure: an unusual clinical manifestation of CADASIL."
Feuerhake F. , Volk B. , Ostertag C.B. , Jungling F.D. , Kassubek J. , Orszagh M. , Dichgans M.
Acta Neuropathol.103:188-192(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL TRP-134
20.

"CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia."
Kalimo H. , Ruchoux M.-M. , Viitanen M. , Kalaria R.N.
Brain Pathol.12:371-384(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL ARG-76; TYR-93; TYR-128; CYS-142; ARG-194; TYR-222; SER-233; ARG-251; CYS-420; GLY-440; CYS-449; CYS-953 AND CYS-1021
21.

"C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke."
Arboleda-Velasquez J.F. , Lopera F. , Lopez E. , Frosch M.P. , Sepulveda-Falla D. , Gutierrez J.E. , Vargas S. , Medina M. , Martinez De Arrieta C. , Lebo R.V. , Slaugenhaupt S.A. , Betensky R.A. , Villegas A. , Arcos-Burgos M. , Rivera D. , Restrepo J.C. , Kosik K.S.
Neurology59:277-279(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL ARG-455
22.

"A novel mutation (C67Y)in the NOTCH3 gene in a Korean CADASIL patient."
Moon S.-Y. , Kim H.-Y. , Seok J.-I. , Kwon J.-C. , Ki C.-S. , Kim J.-W. , Suh Y.-L. , Na D.L.
J. Korean Med. Sci.18:141-144(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL TYR-67
23.

"Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis."
Santa Y. , Uyama E. , Chui D.H. , Arima M. , Kotorii S. , Takahashi K. , Tabira T.
J. Neurol. Sci.212:79-84(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL CYS-90; CYS-133; CYS-169; ARG-174; PHE-174 AND LYS-213
24.

"The influence of genetic and cardiovascular risk factors on the CADASIL phenotype."
Singhal S. , Bevan S. , Barrick T. , Rich P. , Markus H.S.
Brain127:2031-2038(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL ARG-76; CYS-90; CYS-110; CYS-141; CYS-153; CYS-169; CYS-182; ARG-183; CYS-189; SER-194; CYS-207; ARG-251; CYS-332; GLY-440; CYS-607; CYS-953 AND CYS-1231
25.

"Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients."
Opherk C. , Peters N. , Herzog J. , Luedtke R. , Dichgans M.
Brain127:2533-2539(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL GLY-43; PHE-49; CYS-60; SER-65; TRP-76; 77-GLN--CYS-82 DEL; 80-ASP--SER-84 DEL; ARG-87; TYR-87; CYS-90; PHE-93; TRP-106; TYR-108; CYS-110; PHE-117; PHE-123; CYS-133; TRP-134; CYS-141; SER-144; TYR-144; CYS-145; CYS-149; CYS-150; 153-ARG--155-CYS DEL; CYS-153; SER-155; CYS-169; ARG-174; TYR-174; CYS-182; ARG-183; SER-183; PHE-183; ARG-185; PHE-194; TYR-201; CYS-207; TYR-233; 239-ASP--ASP-253 DEL; SER-240; ARG-245; TYR-260; CYS-332; CYS-335; CYS-337; SER-379; ARG-395; CYS-421; TYR-428; ARG-440; SER-446; TYR-484; TYR-495; ARG-511; TYR-549; CYS-558; CYS-985 AND TYR-1261
26.

"Detection of the founder effect in Finnish CADASIL families."
Mykkaenen K. , Savontaus M.L. , Juvonen V. , Sistonen P. , Tuisku S. , Tuominen S. , Penttinen M. , Lundkvist J. , Viitanen M. , Kalimo H. , Peoyhoenen M.
Eur. J. Hum. Genet.12:813-819(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL CYS-133
27.

"Gene symbol: NOTCH3. Disease: CADASIL."
Rojas-Marcos I. , Encarnacion M. , Martinez-Yelamos S. , Ferrer I. , Arbizu T. , Gil-Peralta A. , Garcia-Lozano J.R.
Hum. Genet.115:175-175(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL TRP-108
28.

"Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies."
Peters N. , Opherk C. , Bergmann T. , Castro M. , Herzog J. , Dichgans M.
Arch. Neurol.62:1091-1094(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CADASIL GLY-43; PHE-49; CYS-60; SER-65; TRP-76; 80-ASP--SER-84 DEL; ARG-87; CYS-90; PHE-93; TYR-108; CYS-110; PHE-117; PHE-123; CYS-133; TRP-134; CYS-141; SER-144; TYR-144; CYS-149; CYS-150; CYS-153; 153-ARG--CYS-155 DEL; CYS-169; ARG-174; TYR-174; CYS-182; SER-183; PHE-183; ARG-185; PHE-194; CYS-207; TYR-233; SER-240; ARG-245; TYR-260; 239-ASP--ASP-253 DEL; CYS-319; CYS-332; CYS-335; CYS-337; SER-379; ARG-395; CYS-421; TYR-428; ARG-440; PHE-484; TYR-495; ARG-511; TYR-549; CYS-558; CYS-728; SER-775; CYS-985 AND TYR-1261
29.

"Gene symbol: NOTCH3. Disease: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy."
Soong B.W. , Lee Y.-C. , Lu Y.-C.
Hum. Genet.116:242-242(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CADASIL CYS-118
30.

"Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain."
Fouillade C. , Chabriat H. , Riant F. , Mine M. , Arnoud M. , Magy L. , Bousser M.G. , Tournier-Lasserve E. , Joutel A.
Hum. Mutat.29:452-452(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BRAIN SMALL-VESSEL-DISEASE PRO-1515
31.

"Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis."
Martignetti J.A. , Tian L. , Li D. , Ramirez M.C. , Camacho-Vanegas O. , Camacho S.C. , Guo Y. , Zand D.J. , Bernstein A.M. , Masur S.K. , Kim C.E. , Otieno F.G. , Hou C. , Abdel-Magid N. , Tweddale B. , Metry D. , Fournet J.C. , Papp E. , more...
Am. J. Hum. Genet.92:1001-1007(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMF2 PRO-1519

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